GWAS816927_H QTL Report (Homo sapiens) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
QTL Registration

QTL: GWAS816927_H (reticulocyte measurement QTL GWAS816927 (human)) Homo sapiens

Symbol: GWAS816927_H
Name: reticulocyte measurement QTL GWAS816927 (human)
RGD ID: 407167951
Trait: reticulocyte morphology trait   (VT:0002424)    
Measurement Type: red blood cell measurement   (CMO:0001356)    
LOD Score: Not Available
P Value: 3.0E-11
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh386163,711,969 - 163,711,970RGD_MAPPER_PIPELINEGRCh38
GRCh376164,133,001 - 164,133,002RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS816927_HHumanred blood cell measurement  IAGPrs4709746405850206Based on the EFO term IDGWAS_CATALOGPMID:32888494

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS816927_HHumanreticulocyte morphology trait  IAGPrs4709746405850206Based on the EFO term IDGWAS_CATALOGPMID:32888494

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS816927_HHumanreticulocyte measurement  IAGPrs4709746405850206 GWAS_CATALOGPMID:32888494
GWAS816927_HHumantriglyceride:HDL cholesterol ratio  IAGPrs4709746405850206 GWAS_CATALOGPMID:38200128
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Vertebrate Trait

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs4709746)
Human AssemblyChrPosition (strand)Source
GRCh386163,711,969 - 163,711,970RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406901986GWAS550962_Hdiastolic blood pressure QTL GWAS550962 (human)4e-08BMI-adjusted waist-hip ratiodiastolic blood pressure (CMO:0000005)6163711969163711970Human
407171271GWAS820247_Hsex hormone-binding globulin measurement QTL GWAS820247 (human)5e-11sex hormone-binding globulin measurement6163711969163711970Human
407416716GWAS1065692_Hsystolic blood pressure QTL GWAS1065692 (human)5e-08systolic blood pressuresystolic blood pressure (CMO:0000004)6163711969163711970Human
407004293GWAS653269_Hreticulocyte count QTL GWAS653269 (human)2e-13reticulocyte counttotal reticulocyte count (CMO:0003020)6163711969163711970Human
407352864GWAS1001840_Hsex hormone-binding globulin measurement QTL GWAS1001840 (human)2e-08diastolic blood pressurediastolic blood pressure (CMO:0000005)6163711969163711970Human
407354080GWAS1003056_HBMI-adjusted hip circumference QTL GWAS1003056 (human)5e-09BMI-adjusted hip circumferencehip circumference (CMO:0000014)6163711969163711970Human
407353775GWAS1002751_Htriglyceride measurement QTL GWAS1002751 (human)4e-09type 2 diabetes mellitusblood triglyceride level (CMO:0000118)6163711969163711970Human
407292908GWAS941884_Hheel bone mineral density QTL GWAS941884 (human)5e-32heel bone mineral densitybone mineral density (CMO:0001226)6163711969163711970Human
407352269GWAS1001245_Hsex hormone-binding globulin measurement QTL GWAS1001245 (human)0.000003sex hormone-binding globulin measurement6163711969163711970Human
407167951GWAS816927_Hreticulocyte measurement QTL GWAS816927 (human)3e-11reticulocyte morphology trait (VT:0002424)red blood cell measurement (CMO:0001356)6163711969163711970Human
407164266GWAS813242_Hreticulocyte count QTL GWAS813242 (human)4e-12triglyceride measurementblood triglyceride level (CMO:0000118)6163711969163711970Human
407259734GWAS908710_Hsex hormone-binding globulin measurement QTL GWAS908710 (human)7e-12sex hormone-binding globulin measurement6163711969163711970Human
407166390GWAS815366_Htype 2 diabetes mellitus QTL GWAS815366 (human)0.000004type 2 diabetes mellitus6163711969163711970Human
407395866GWAS1044842_Htype 2 diabetes mellitus QTL GWAS1044842 (human)4e-10type 2 diabetes mellitus6163711969163711970Human
407006673GWAS655649_Hreticulocyte measurement QTL GWAS655649 (human)1e-12reticulocyte morphology trait (VT:0002424)red blood cell measurement (CMO:0001356)6163711969163711970Human
407387004GWAS1035980_Hsex hormone-binding globulin measurement QTL GWAS1035980 (human)8e-09sex hormone-binding globulin measurement6163711969163711970Human
1643404BMD3_HBone mineral density QTL 3 (human)2.420.0005Bone mineral density6157563614170805979Human
407074292GWAS723268_Hbody height QTL GWAS723268 (human)9e-28body height (VT:0001253)body height (CMO:0000106)6163711969163711970Human
407075291GWAS724267_Htriglyceride measurement QTL GWAS724267 (human)6e-11triglyceride measurementblood triglyceride level (CMO:0000118)6163711969163711970Human
407147006GWAS795982_Htype 2 diabetes mellitus QTL GWAS795982 (human)2e-21type 2 diabetes mellitus6163711969163711970Human
407149528GWAS798504_Htype 2 diabetes mellitus QTL GWAS798504 (human)1e-16type 2 diabetes mellitus6163711969163711970Human
407328731GWAS977707_Hsex hormone-binding globulin measurement QTL GWAS977707 (human)6e-17sex hormone-binding globulin measurement6163711969163711970Human
1643367BW323_HBody weight QTL 323 (human)2.420.0005Body fat amount6157563614170805979Human
407089149GWAS738125_Htype 2 diabetes mellitus QTL GWAS738125 (human)6e-09triglyceride:HDL cholesterol ratio6163711969163711970Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS550962_H GCST007094 Diastolic blood pressure 295,529 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 2,029 African British individuals, 7,701 East Asian ancestry individuals, 2,735 South Asian ancestry individuals, 1,979 mixed and unknown ancestry individuals C NR 4E-8 7.398 rs4709746 0.19 diastolic blood pressure (EFO:0006336)
 PMID:27841878
GWAS653269_H GCST90002385 High light scatter reticulocyte count 408,112 British individuals T 0.134109 2E-13 12.699 rs4709746 0.024020366 reticulocyte count (EFO:0007986)
 PMID:32888494
GWAS655649_H GCST90002386 High light scatter reticulocyte percentage of red cells 408,112 British individuals T 0.134125 1E-12 12 rs4709746 0.023132678 reticulocyte measurement (EFO:0010700)
 PMID:32888494
GWAS723268_H GCST007841 Height approximately 458,000 European ancestry individuals ? NR 9E-28 27.046 rs4709746 N/A body height (EFO:0004339)
 PMID:30595370
GWAS724267_H GCST010244 Triglyceride levels 441,016 European ancestry individuals C 0.865986 6E-11 10.222 rs4709746 0.0192174 triglyceride measurement (EFO:0004530)
 PMID:32203549
GWAS738125_H GCST009379 Type 2 diabetes 74,124 European ancestry cases, 824,006 European ancestry controls C 0.8676 6E-9 8.222 rs4709746 1.06 PMID:30297969
GWAS795982_H GCST010557 Type 2 diabetes 148,726 European ancestry cases, 24,646 African American cases, 8,616 Hispanic cases, 46,511 Asian ancestry cases, 965,732 European ancestry controls, 31,446 African American controls, 11,829 Hispanic controls, 169,776 Asian ancestry controls C 0.866 2E-21 20.699 rs4709746 0.0565 PMID:32541925
GWAS798504_H GCST010555 Type 2 diabetes 148,726 European ancestry cases, 965,732 European ancestry controls C 0.8687 1E-16 16 rs4709746 0.0581 PMID:32541925
GWAS813242_H GCST90002405 Reticulocyte count 408,112 British individuals T 0.134081 4E-12 11.398 rs4709746 0.022824526 reticulocyte count (EFO:0007986)
 PMID:32888494
GWAS815366_H GCST007847 Type 2 diabetes 36,614 Japanese ancestry cases, 155,150 Japanese ancestry controls C 0.87 0.000004 5.398 rs4709746 1.0638298 PMID:30718926
GWAS816927_H GCST90002406 Reticulocyte fraction of red cells 408,112 British individuals T 0.13409 3E-11 10.523 rs4709746 0.021788007 reticulocyte measurement (EFO:0010700)
 PMID:32888494
GWAS820247_H GCST90012106 Sex hormone-binding globulin levels adjusted for BMI 188,908 European ancestry women T 0.134119 5E-11 10.302 rs4709746 0.0117766 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS908710_H GCST90239822 Sex hormone-binding globulin levels 188,443 British ancestry women ? NR 7E-12 11.155 rs4709746 0.0308592 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:36653534
GWAS941884_H GCST006433 Heel bone mineral density 394,929 European ancestry individuals ? NR 5E-32 31.302 rs4709746 0.0342644 heel bone mineral density (EFO:0009270)
 PMID:30048462
GWAS977707_H GCST90012110 Sex hormone-binding globulin levels adjusted for BMI 368,929 European ancestry individuals T 0.13412599999999997 6E-17 16.222 rs4709746 0.00992161 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
None Available GCST90104273 Sex hormone-binding globulin levels 196,901 European ancestry individuals T 0.131211 6E-9 8.222 rs4709746 0.0273601 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
None Available GCST90295949 Triglyceride to HDL cholesterol ratio 402,398 European ancestry individuals C 0.8659 3E-11 10.523 rs4709746 0.0307 triglyceride:HDL cholesterol ratio (EFO:0007929)
 PMID:38200128
GWAS1001245_H GCST90104277 Sex hormone-binding globulin levels in postmenopausal women 92,911 European ancestry individuals T 0.131211 0.000003 5.523 rs4709746 0.0321852 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS1001840_H GCST90104297 Sex hormone-binding globulin levels 4,522 African ancestry individuals, 196,901 European ancestry individuals ? NR 2E-8 7.699 rs4709746 5.647 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS1002751_H GCST90019523 Triglyceride levels 342,233 European ancestry individuals, 6,014 African ancestry individuals, 7,330 South Asian ancestry individuals T NR 4E-9 8.398 rs4709746 0.0209 triglyceride measurement (EFO:0004530)
 PMID:33462484
None Available GCST90020025 Waist-to-hip ratio adjusted for BMI 219,872 British ancestry women T NR 4E-8 7.398 rs4709746 0.0227376 BMI-adjusted waist-hip ratio (EFO:0007788)
 PMID:34021172
GWAS1003056_H GCST90020028 Hip circumference adjusted for BMI 219,872 British ancestry women T NR 5E-9 8.302 rs4709746 0.0242373 BMI-adjusted hip circumference (EFO:0008039)
 PMID:34021172
None Available GCST90295951 Triglyceride to HDL cholesterol ratio 216,649 European ancestry individuals C 0.866 6E-9 8.222 rs4709746 0.0312 triglyceride:HDL cholesterol ratio (EFO:0007929)
 PMID:38200128
None Available GCST90244680 Triglyceride levels in non-type 2 diabetes 402,944 European ancestry individuals ? NR 4E-12 11.398 rs4709746 N/A triglyceride measurement (EFO:0004530)
 PMID:36269708
GWAS1035980_H GCST90012111 Sex hormone-binding globulin levels 370,125 European ancestry individuals T 0.13412599999999997 8E-9 8.097 rs4709746 0.00756802 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
None Available GCST90132184 Type 2 diabetes 251,740 European ancestry individuals C 0.869 4E-9 8.398 rs4709746 0.057 PMID:35551307
GWAS1044842_H GCST90132183 Type 2 diabetes 251,740 European ancestry individuals, 139,705 East Asian ancestry individuals, 40,737 South Asian ancestry individuals, 27,417 Hispanic individuals, 30,167 African American individuals, 2,426 Zulu ancestry individuals C NR 4E-10 9.398 rs4709746 1.05 PMID:35551307
GWAS1065692_H GCST90310294 Systolic blood pressure 1,028,980 European ancestry individuals T NR 5E-8 7.302 rs4709746 0.198 systolic blood pressure (EFO:0006335)
 PMID:38689001
None Available GCST90310295 Diastolic blood pressure 1,028,980 European ancestry individuals T NR 2E-8 7.699 rs4709746 0.1261 diastolic blood pressure (EFO:0006336)
 PMID:38689001
Database Acc Id Source(s)
GWAS Catalog GCST90002406 GWAS Catalog
  GCST90295949 GWAS Catalog

RGD Curation Notes
Note Type Note Reference