GWAS811863_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS811863_H (FEV/FVC ratio, response to bronchodilator QTL GWAS811863 (human)) Homo sapiens

Symbol: GWAS811863_H
Name: FEV/FVC ratio, response to bronchodilator QTL GWAS811863 (human)
RGD ID: 407162887
Trait: FEV/FVC ratio, response to bronchodilator
Measurement Type: forced expiratory volume to forced vital capacity ratio   (CMO:0000241)    
LOD Score: Not Available
P Value: 3.0E-7
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381578,615,812 - 78,615,813RGD_MAPPER_PIPELINEGRCh38
GRCh371578,908,154 - 78,908,155RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS811863_HHumanforced expiratory volume to forced vital capacity ratio  IAGPrs8043009405850206Based on the EFO term IDGWAS_CATALOGPMID:26634245

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS811863_HHumanFEV/FVC ratio  IAGPrs8043009405850206 GWAS_CATALOGPMID:26634245
GWAS811863_HHumanresponse to bronchodilator  IAGPrs8043009405850206 GWAS_CATALOGPMID:26634245
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
732613CHRNA3cholinergic receptor nicotinic alpha 3 subunit157859305278620996Human

Position Markers

Peak: (rs8043009)
Human AssemblyChrPosition (strand)Source
GRCh381578,615,812 - 78,615,813RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406977392GWAS626368_Hforced expiratory volume, response to bronchodilator QTL GWAS626368 (human)6e-08forced expiratory volume, response to bronchodilatorforced expiratory volume (CMO:0000254)157861581278615813Human
407162887GWAS811863_HFEV/FVC ratio, response to bronchodilator QTL GWAS811863 (human)0.0000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)157861581278615813Human
407135738GWAS784714_Hschizophrenia QTL GWAS784714 (human)3e-12schizophrenia157861581278615813Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS626368_H GCST003262 Post bronchodilator FEV1 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals C 0.236 6E-8 7.222 rs8043009 0.055 forced expiratory volume (EFO:0004314)
response to bronchodilator (GO:0097366)
 PMID:26634245
GWAS784714_H GCST008459 Schizophrenia 816 Indian ancestry cases, 900 Indian ancestry controls, 505 Indian ancestry cases and 871 Indian ancestry controls from 405 families, up to 36,989 European and unknown ancestry cases, up to 113,075 European and unknown ancestry controls ? NR 3E-12 11.523 rs8043009 N/A PMID:31268507
GWAS811863_H GCST003264 Post bronchodilator FEV1/FVC ratio 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals C 0.237 3E-7 6.523 rs8043009 0.01 FEV/FVC ratio (EFO:0004713)
response to bronchodilator (GO:0097366)
 PMID:26634245
Database Acc Id Source(s)
GWAS Catalog GCST003264 GWAS Catalog

RGD Curation Notes
Note Type Note Reference