GWAS739565_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS739565_H (cholesterol esters in large HDL measurement QTL GWAS739565 (human)) Homo sapiens

Symbol: GWAS739565_H
Name: cholesterol esters in large HDL measurement QTL GWAS739565 (human)
RGD ID: 407090589
Trait: cholesterol esters in large HDL measurement
LOD Score: Not Available
P Value: 3.0E-19
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38643,789,345 - 43,789,346RGD_MAPPER_PIPELINEGRCh38
GRCh37643,757,082 - 43,757,083RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS739565_HHumancholesterol esters in large HDL measurement  IAGPrs4711750405850206 GWAS_CATALOGPMID:38448586
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs4711750)
Human AssemblyChrPosition (strand)Source
GRCh38643,789,345 - 43,789,346RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407085376GWAS734352_Hesterified cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS734352 (human)5e-10esterified cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407391371GWAS1040347_Haspartate aminotransferase measurement QTL GWAS1040347 (human)1e-23aspartate aminotransferase measurementblood aspartate aminotransferase activity level (CMO:0000580)64378934543789346Human
407410571GWAS1059547_Htriglyceride measurement, high density lipoprotein cholesterol measurement QTL GWAS1059547 (human)1e-08triglyceride measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407090565GWAS739541_Hfree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS739541 (human)8e-14free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407075151GWAS724127_Hcholesterol to total lipids in very large VLDL percentage QTL GWAS724127 (human)3e-10cholesterol to total lipids in very large VLDL percentage 64378934543789346Human
407409157GWAS1058133_Hgluteofemoral adipose tissue measurement QTL GWAS1058133 (human)6e-15gluteofemoral adipose tissue measurement64378934543789346Human
407089682GWAS738658_Hserum alanine aminotransferase measurement QTL GWAS738658 (human)4e-14serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)64378934543789346Human
407079761GWAS728737_Hphospholipids in large HDL measurement QTL GWAS728737 (human)5e-18phospholipids in large HDL measurementblood high density lipoprotein phospholipid level (CMO:0001565)64378934543789346Human
407410202GWAS1059178_Hserum alanine aminotransferase measurement QTL GWAS1059178 (human)5e-08serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)64378934543789346Human
407388315GWAS1037291_Hmyeloid white cell count QTL GWAS1037291 (human)7e-09myeloid white cell countwhite blood cell count (CMO:0000027)64378934543789346Human
407090582GWAS739558_Hmyocardial infarction QTL GWAS739558 (human)0.000001myocardial infarction64378934543789346Human
407091221GWAS740197_Htotal lipids in large HDL QTL GWAS740197 (human)4e-19total lipids in large HDL64378934543789346Human
407388958GWAS1037934_Hreticulocyte count QTL GWAS1037934 (human)7e-11reticulocyte counttotal reticulocyte count (CMO:0003020)64378934543789346Human
407088667GWAS737643_Htotal cholesterol change measurement, high density lipoprotein cholesterol measurement QTL GWAS737643 (human)2e-19total cholesterol change measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407084378GWAS733354_Hphospholipids:total lipids ratio QTL GWAS733354 (human)5e-11reticulocyte counttotal reticulocyte count (CMO:0003020)64378934543789346Human
407079129GWAS728105_Hhigh density lipoprotein cholesterol measurement QTL GWAS728105 (human)7e-19high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407253340GWAS902316_Hmyocardial infarction QTL GWAS902316 (human)0.0000005myocardial infarction64378934543789346Human
407396563GWAS1045539_Hnon-alcoholic fatty liver disease QTL GWAS1045539 (human)1e-21non-alcoholic fatty liver disease64378934543789346Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
407090589GWAS739565_Hcholesterol esters in large HDL measurement QTL GWAS739565 (human)3e-19cholesterol esters in large HDL measurement64378934543789346Human
407414935GWAS1063911_Htype 2 diabetes mellitus QTL GWAS1063911 (human)1e-12type 2 diabetes mellitus64378934543789346Human
407026400GWAS675376_Hcholesterol to total lipids in large HDL percentage QTL GWAS675376 (human)1e-18cholesterol to total lipids in large HDL percentage 64378934543789346Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
407383019GWAS1031995_Hreticulocyte measurement QTL GWAS1031995 (human)4e-22reticulocyte morphology trait (VT:0002424)red blood cell measurement (CMO:0001356)64378934543789346Human
407407788GWAS1056764_Hserum alanine aminotransferase measurement QTL GWAS1056764 (human)3e-16serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)64378934543789346Human
407133602GWAS782578_Hfree cholesterol in very large HDL measurement QTL GWAS782578 (human)5e-12free cholesterol in very large HDL measurement 64378934543789346Human
407378862GWAS1027838_Hheel bone mineral density QTL GWAS1027838 (human)7e-12heel bone mineral densitybone mineral density (CMO:0001226)64378934543789346Human
407135852GWAS784828_Hhigh density lipoprotein cholesterol measurement QTL GWAS784828 (human)3e-15high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407024744GWAS673720_Hcholesteryl esters to total lipids in large HDL percentage QTL GWAS673720 (human)1e-17cholesteryl esters to total lipids in large HDL percentage 64378934543789346Human
407392354GWAS1041330_Hhigh density lipoprotein cholesterol measurement QTL GWAS1041330 (human)4e-08high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407409445GWAS1058421_Hgluteofemoral adipose tissue measurement QTL GWAS1058421 (human)1e-09gluteofemoral adipose tissue measurement64378934543789346Human
407089325GWAS738301_Htriglyceride measurement QTL GWAS738301 (human)8e-18serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)64378934543789346Human
407219191GWAS868167_Hreticulocyte measurement QTL GWAS868167 (human)4e-21reticulocyte morphology trait (VT:0002424)red blood cell measurement (CMO:0001356)64378934543789346Human
407046839GWAS695815_Htriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement QTL GWAS695815 (human)2e-10triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurementblood very low density lipoprotein cholesterol level (CMO:0000648)64378934543789346Human
407137020GWAS785996_Htotal lipids in very large HDL measurement QTL GWAS785996 (human)7e-15total lipids in very large HDL measurement 64378934543789346Human
407090681GWAS739657_Hfree cholesterol in large HDL measurement QTL GWAS739657 (human)1e-19free cholesterol in large HDL measurementblood high density lipoprotein cholesterol level (CMO:0000052)64378934543789346Human
407392311GWAS1041287_Hserum alanine aminotransferase measurement QTL GWAS1041287 (human)3e-28serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)64378934543789346Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS673720_H GCST90269733 Cholesteryl esters to total lipids in large HDL percentage (UKB data field 23636) 88,329 European ancestry individuals A 0.499858 1E-17 17 rs4711750 0.038868 cholesteryl esters to total lipids in large HDL percentage (EFO:0022248)
 PMID:36764567
GWAS675376_H GCST90269732 Cholesterol to total lipids in large HDL percentage (UKB data field 23635) 88,329 European ancestry individuals A 0.499858 1E-18 18 rs4711750 0.0394902 cholesterol to total lipids in large HDL percentage (EFO:0022234)
 PMID:36764567
GWAS695815_H GCST90302115 Triglycerides to total lipids ratio in small VLDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5064 2E-10 9.699 rs4711750 0.0255 triglycerides:total lipids ratio (EFO:0020947)
very low density lipoprotein cholesterol measurement (EFO:0008317)
 PMID:38448586
GWAS724127_H GCST90269682 Cholesterol to total lipids in very large VLDL percentage (UKB data field 23585) 87,620 European ancestry individuals A 0.499852 3E-10 9.523 rs4711750 0.0285365 cholesterol to total lipids in very large VLDL percentage (EFO:0022244)
 PMID:36764567
GWAS728105_H GCST90302002 Concentration of large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5079 7E-19 18.155 rs4711750 0.0364 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS728737_H GCST90302003 Phospholipids in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5079 5E-18 17.302 rs4711750 0.0354 phospholipids in large HDL measurement (EFO:0022190)
 PMID:38448586
GWAS733354_H GCST90269731 Phospholipids to total lipids in large HDL percentage (UKB data field 23634) 88,329 European ancestry individuals A 0.499858 5E-11 10.302 rs4711750 0.0302068 phospholipids:total lipids ratio (EFO:0020946)
 PMID:36764567
GWAS734352_H GCST90302032 Total cholesterol to total lipids ratio in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5074 5E-10 9.302 rs4711750 0.0254 esterified cholesterol measurement (EFO:0008589)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS737643_H GCST90301995 Total cholesterol in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5079 2E-19 18.699 rs4711750 0.0366 total cholesterol change measurement (EFO:0007806)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS738301_H GCST011345 Triglyceride levels 76,081 European ancestry individuals, 127,395 Japanese ancestry individuals ? NR 8E-18 17.097 rs4711750 0.0334 triglyceride measurement (EFO:0004530)
 PMID:33339817
GWAS738658_H GCST90011898 Alanine aminotransferase levels 390,812 European ancestry individuals A 0.5 4E-14 13.398 rs4711750 7.58 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:33547301
GWAS739541_H GCST90302000 Free cholesterol to total lipids ratio in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5066 8E-14 13.097 rs4711750 0.0306 free cholesterol:total lipids ratio (EFO:0020945)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS739558_H GCST011365 Myocardial infarction 14,825 European ancestry cases, 44,000 European and unknown ancestry cases, 2,680 cases, 380,970 European ancestry controls, 123,504 European and unknown ancestry controls, 73,242 controls A 0.499289 0.000001 6 rs4711750 1.04 myocardial infarction (EFO:0000612)
 PMID:33532862
GWAS739565_H GCST90301997 Cholesterol esters in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5079 3E-19 18.523 rs4711750 0.0364 cholesterol esters in large HDL measurement (EFO:0022159)
 PMID:38448586
GWAS739657_H GCST90301999 Free cholesterol in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5079 1E-19 19 rs4711750 0.0371 free cholesterol in large HDL measurement (EFO:0022157)
 PMID:38448586
GWAS740197_H GCST90302001 Total lipids in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5079 4E-19 18.398 rs4711750 0.0366 total lipids in large HDL (EFO:0022189)
 PMID:38448586
GWAS782578_H GCST90302130 Free cholesterol in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5082 5E-12 11.302 rs4711750 0.0284 free cholesterol in very large HDL measurement (EFO:0022273)
 PMID:38448586
GWAS784828_H GCST90302133 Concentration of very large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5082 3E-15 14.523 rs4711750 0.0325 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS785996_H GCST90302132 Total lipids in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.5082 7E-15 14.155 rs4711750 0.0321 total lipids in very large HDL measurement (EFO:0022312)
 PMID:38448586
GWAS868167_H GCST90002406 Reticulocyte fraction of red cells 408,112 British individuals A 0.500226 4E-21 20.398 rs4711750 0.02093351 reticulocyte measurement (EFO:0010700)
 PMID:32888494
GWAS902316_H GCST90432175 Myocardial infarction 3,950 Saudi Arabian ancestry cases, 2,324 Saudi Arabian ancestry controls, 56,278 European and unknown ancestry cases, 577,716 European and unknown ancestry controls ? NR 5E-7 6.302 rs4711750 0.962 myocardial infarction (EFO:0000612)
 PMID:38072966
None Available GCST90428729 Alanine aminotransferase levels 1,010,710 European ancestry individuals A NR 8E-18 17.097 rs4711750 0.0033 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:38632349
None Available GCST004612 High light scatter reticulocyte percentage of red cells 170,763 European ancestry individuals A 0.4997 5E-11 10.302 rs4711750 0.02342795 reticulocyte count (EFO:0007986)
 PMID:27863252
GWAS1027838_H GCST006979 Heel bone mineral density 426,824 British ancestry individuals T 0.49938 7E-12 11.155 rs4711750 0.012546 heel bone mineral density (EFO:0009270)
 PMID:30598549
None Available GCST90444202 Type 2 diabetes 51,256 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry cases, 370,487 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry controls T 0.510823 2E-19 18.699 rs4711750 0.0721 PMID:39379762
GWAS1031995_H GCST90002386 High light scatter reticulocyte percentage of red cells 408,112 British individuals A 0.500197 4E-22 21.398 rs4711750 0.021331951 reticulocyte measurement (EFO:0010700)
 PMID:32888494
GWAS1037291_H GCST004626 Myeloid white cell count 169,219 European ancestry individuals A 0.5001 7E-9 8.155 rs4711750 0.02079017 myeloid white cell count (EFO:0007988)
 PMID:27863252
GWAS1037934_H GCST004619 Reticulocyte fraction of red cells 170,690 European ancestry individuals A 0.4998 7E-11 10.155 rs4711750 0.0233458 reticulocyte count (EFO:0007986)
 PMID:27863252
GWAS1040347_H GCST90013664 Aspartate aminotransferase levels 386,570 British ancestry individuals, 10,617 Asian or Asian British individuals, 7,426 Black or Black British individuals, 2,321 Chinese ancestry individuals ? NR 1E-23 23 rs4711750 0.0023 aspartate aminotransferase measurement (EFO:0004736)
 PMID:34315874
GWAS1041287_H GCST90013663 Alanine aminotransferase levels 387,859 British ancestry individuals, 10,635 Asian or Asian British individuals, 7,468 Black or Black British individuals, 2,338 Chinese ancestry individuals ? NR 3E-28 27.523 rs4711750 0.0043 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:34315874
GWAS1041330_H GCST90239650 High density lipoprotein cholesterol levels 99,432 Admixed African or African ancestry individuals A 0.192128 4E-8 7.398 rs4711750 0.0338458 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:34887591
GWAS1045539_H GCST90094908 Nonalcoholic fatty liver disease (imputed) 28,396 European ancestry cases, 108,652 European ancestry controls ? NR 1E-21 21 rs4711750 0.00869145 non-alcoholic fatty liver disease (EFO:0003095)
 PMID:35047847
GWAS1056764_H GCST90013405 Liver enzyme levels (alanine transaminase) 437,267 European ancestry individuals T 0.499922 3E-16 15.523 rs4711750 0.00322879 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:33972514
GWAS1058133_H GCST90205202 Gluteofemoral adipose tissue volumes 38,965 European ancestry, East Asian ancestry, South Asian ancestry, African ancestry, NR ancestry individuals T 0.5 6E-15 14.222 rs4711750 0.054 gluteofemoral adipose tissue measurement (EFO:0803317)
 PMID:35773277
GWAS1058421_H GCST90205220 Gluteofemoral adipose tissue volumes 19,093 European ancestry, East Asian ancestry, South Asian ancestry, African ancestry, NR ancestry females T 0.5 1E-9 9 rs4711750 0.06 gluteofemoral adipose tissue measurement (EFO:0803317)
 PMID:35773277
GWAS1059178_H GCST90129601 Chronic elevation of alanine aminotransferase (cALT) levels 95,472 European ancestry cases, 68,725 European ancestry controls, 23,977 African American cases, 13,387 African American controls, 7,650 Hispanic cases, 7,468 Hispanic controls, 1,088 Asian ancestry cases, 828 Asian ancestry controls A 0.465 5E-8 7.302 rs4711750 0.037 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:35654975
GWAS1059547_H GCST90092902 Triglyceride levels in medium HDL 115,082 European ancestry individuals T 0.500217 1E-8 8 rs4711750 0.0231606 triglyceride measurement (EFO:0004530)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS1063911_H GCST90018926 Type 2 diabetes 38,841 European ancestry cases, 451,248 European ancestry controls, 45,383 East Asian ancestry cases, 132,032 East Asian ancestry controls A NR 1E-12 12 rs4711750 0.0448 PMID:34594039
Database Acc Id Source(s)
GWAS Catalog GCST90301997 GWAS Catalog

RGD Curation Notes
Note Type Note Reference