GWAS733133_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS733133_H (free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS733133 (human)) Homo sapiens

Symbol: GWAS733133_H
Name: free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS733133 (human)
RGD ID: 407084157
Trait: free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement
Measurement Type: blood high density lipoprotein cholesterol level   (CMO:0000052)    
LOD Score: Not Available
P Value: 2.0E-12
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38139,157,635 - 39,157,636RGD_MAPPER_PIPELINEGRCh38
GRCh37139,623,307 - 39,623,308RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS733133_HHumanblood high density lipoprotein cholesterol level  IAGPrs10888682405850206Based on the EFO term IDGWAS_CATALOGPMID:38448586

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS733133_HHumanfree cholesterol:total lipids ratio  IAGPrs10888682405850206 GWAS_CATALOGPMID:38448586
GWAS733133_HHumanhigh density lipoprotein cholesterol measurement  IAGPrs10888682405850206 GWAS_CATALOGPMID:38448586
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1352225MACF1microtubule actin crosslinking factor 113908416739487138Human

Position Markers

Peak: (rs10888682)
Human AssemblyChrPosition (strand)Source
GRCh38139,157,635 - 39,157,636RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407071235GWAS720211_Hapolipoprotein A 1 measurement QTL GWAS720211 (human)7e-15apolipoprotein A 1 measurementblood apolipoprotein AI level (CMO:0000520)13915763539157636Human
407084515GWAS733491_Htotal cholesterol change measurement, high density lipoprotein cholesterol measurement QTL GWAS733491 (human)8e-17total cholesterol change measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)13915763539157636Human
407061776GWAS710752_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS710752 (human)6e-19total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)13915763539157636Human
407065606GWAS714582_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS714582 (human)8e-18total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)13915763539157636Human
407083547GWAS732523_Hfree cholesterol in large HDL measurement QTL GWAS732523 (human)2e-16free cholesterol in large HDL measurementblood high density lipoprotein cholesterol level (CMO:0000052)13915763539157636Human
407130367GWAS779343_Hhigh density lipoprotein cholesterol measurement QTL GWAS779343 (human)2e-10high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)13915763539157636Human
407079743GWAS728719_Hhigh density lipoprotein cholesterol measurement QTL GWAS728719 (human)3e-17high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)13915763539157636Human
407136073GWAS785049_Hphospholipids in very large HDL measurement QTL GWAS785049 (human)6e-13phospholipids in very large HDL measurement 13915763539157636Human
407084157GWAS733133_Hfree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS733133 (human)2e-12free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)13915763539157636Human
407089517GWAS738493_Hcholesterol esters in large HDL measurement QTL GWAS738493 (human)6e-17cholesterol esters in large HDL measurement13915763539157636Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS710752_H GCST90301969 Total cholesterol in HDL2 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 6E-19 18.222 rs10888682 0.039 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS714582_H GCST90301971 Total cholesterol levels in HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 8E-18 17.097 rs10888682 0.0377 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS720211_H GCST90301945 Apolipoprotein A-I levels 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 7E-15 14.155 rs10888682 0.0341 apolipoprotein A 1 measurement (EFO:0004614)
 PMID:38448586
GWAS728719_H GCST90302002 Concentration of large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 3E-17 16.523 rs10888682 0.0371 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS732523_H GCST90301999 Free cholesterol in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 2E-16 15.699 rs10888682 0.0361 free cholesterol in large HDL measurement (EFO:0022157)
 PMID:38448586
GWAS733133_H GCST90302036 Free cholesterol to total lipids ratio in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2983 2E-12 11.699 rs10888682 0.0308 free cholesterol:total lipids ratio (EFO:0020945)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS733491_H GCST90301995 Total cholesterol in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 8E-17 16.097 rs10888682 0.0365 total cholesterol change measurement (EFO:0007806)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS738493_H GCST90301997 Cholesterol esters in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 6E-17 16.222 rs10888682 0.0367 cholesterol esters in large HDL measurement (EFO:0022159)
 PMID:38448586
None Available GCST90302001 Total lipids in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 3E-17 16.523 rs10888682 0.037 total lipids in large HDL (EFO:0022189)
 PMID:38448586
GWAS779343_H GCST90302133 Concentration of very large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2979 2E-10 9.699 rs10888682 0.028 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS785049_H GCST90302134 Phospholipids in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2978 6E-13 12.222 rs10888682 0.0316 phospholipids in very large HDL measurement (EFO:0022298)
 PMID:38448586
Database Acc Id Source(s)
GWAS Catalog GCST90302036 GWAS Catalog

RGD Curation Notes
Note Type Note Reference