GWAS724744_H QTL Report (Homo sapiens) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
QTL Registration

QTL: GWAS724744_H (QRS duration QTL GWAS724744 (human)) Homo sapiens

Symbol: GWAS724744_H
Name: QRS duration QTL GWAS724744 (human)
RGD ID: 407075768
Trait: QRS duration
Measurement Type: QRS duration   (CMO:0000267)    
LOD Score: Not Available
P Value: 1.0E-37
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381766,322,239 - 66,322,240RGD_MAPPER_PIPELINEGRCh38
GRCh371764,318,357 - 64,318,358RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS724744_HHumanQRS duration  IAGPrs9912468405850206Based on the EFO term IDGWAS_CATALOGPMID:30012220

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS724744_HHumanQRS duration  IAGPrs9912468405850206 GWAS_CATALOGPMID:30012220
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement
QRS duration  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
737062PRKCAprotein kinase C alpha176630261366810743Human

Position Markers

Peak: (rs9912468)
Human AssemblyChrPosition (strand)Source
GRCh381766,322,239 - 66,322,240RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406906977GWAS555953_HQRS duration QTL GWAS555953 (human)1e-08QRS durationQRS duration (CMO:0000267)176632223966322240Human
406974054GWAS623030_HQRS complex, QRS duration QTL GWAS623030 (human)2e-11QRS complex, QRS durationQRS duration (CMO:0000267)176632223966322240Human
406973192GWAS622168_HQRS amplitude, QRS complex QTL GWAS622168 (human)3e-12QRS amplitude, QRS complexQRS amplitude (CMO:0000268)176632223966322240Human
407150766GWAS799742_HQT interval QTL GWAS799742 (human)2e-15QT intervalQT interval (CMO:0000235)176632223966322240Human
407088137GWAS737113_HQRS duration QTL GWAS737113 (human)8e-19QRS durationQRS duration (CMO:0000267)176632223966322240Human
407075768GWAS724744_HQRS duration QTL GWAS724744 (human)1e-37QRS durationQRS duration (CMO:0000267)176632223966322240Human
406929932GWAS578908_Hbody height QTL GWAS578908 (human)0.0000008body height (VT:0001253)body height (CMO:0000106)176632223966322240Human
406991100GWAS640076_HQRS duration QTL GWAS640076 (human)0.0000007QRS durationQRS duration (CMO:0000267)176632223966322240Human
406973838GWAS622814_HQRS amplitude, QRS complex QTL GWAS622814 (human)5e-11QRS amplitude, QRS complexQRS amplitude (CMO:0000268)176632223966322240Human
406990077GWAS639053_HQRS duration QTL GWAS639053 (human)1e-10QRS durationQRS duration (CMO:0000267)176632223966322240Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS555953_H GCST003598 QRS duration up to 13,031 African American individuals, 40,407 European ancestry individuals C 0.57 1E-8 8 rs9912468 0.39 QRS duration (EFO:0005055)
 PMID:27577874
GWAS578908_H GCST005908 Height 253,288 European ancestry individuals C 0.419069029357312 8E-7 6.097 rs9912468 N/A body height (EFO:0004339)
 PMID:29782485
GWAS622168_H GCST003870 QRS complex (Sokolow-Lyon) up to 54,303 European ancestry individuals, up to 690 Orcadian (founder/genetic isolate) individuals ? NR 3E-12 11.523 rs9912468 32.05 QRS amplitude (EFO:0007742)
QRS complex (EFO:0005054)
 PMID:27659466
GWAS622814_H GCST003872 QRS complex (12-leadsum) up to 47,942 European ancestry individuals, up to 690 Orcadian (founder/genetic isolate) individuals ? NR 5E-11 10.302 rs9912468 N/A QRS amplitude (EFO:0007742)
QRS complex (EFO:0005054)
 PMID:27659466
GWAS623030_H GCST003844 QRS duration 59,565 European ancestry individuals, 690 Orcadian (founder/genetic isolate) individuals ? NR 2E-11 10.699 rs9912468 N/A QRS complex (EFO:0005054)
QRS duration (EFO:0005055)
 PMID:27659466
GWAS639053_H GCST003598 QRS duration up to 13,031 African American individuals, 40,407 European ancestry individuals C NR 1E-10 10 rs9912468 0.38 QRS duration (EFO:0005055)
 PMID:27577874
GWAS640076_H GCST008054 QRS duration 3,274 African American individuals, 13,420 Hispanic/Latino individuals, 126 Asian ancestry individuals, 226 Native American ancestry individuals ? NR 7E-7 6.155 rs9912468 0.4569705 QRS duration (EFO:0005055)
 PMID:31217584
GWAS724744_H GCST007104 QRS duration up to 77,898 European ancestry individuals, up to 7,695 African American individuals G 0.407849 1E-37 37 rs9912468 0.428866 QRS duration (EFO:0005055)
 PMID:30012220
GWAS737113_H GCST007103 QRS duration 77,898 European ancestry individuals G 0.42067671371597 8E-19 18.097 rs9912468 0.4210582 QRS duration (EFO:0005055)
 PMID:30012220
GWAS799742_H GCST010919 QT interval 83,884 European ancestry individuals, 9,610 African American individuals, 1,382 Hispanic individuals, 750 East Asian ancestry individuals. G 0.417 2E-15 14.699 rs9912468 0.68 QT interval (EFO:0004682)
 PMID:29874175
Database Acc Id Source(s)
GWAS Catalog GCST007104 GWAS Catalog

RGD Curation Notes
Note Type Note Reference