GWAS712165_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS712165_H (total cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS712165 (human)) Homo sapiens

Symbol: GWAS712165_H
Name: total cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS712165 (human)
RGD ID: 407063189
Trait: total cholesterol measurement, high density lipoprotein cholesterol measurement
Measurement Type: blood high density lipoprotein cholesterol level   (CMO:0000052)    
blood total cholesterol level   (CMO:0000051)    
LOD Score: Not Available
P Value: 1.0E-10
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381220,321,772 - 20,321,773RGD_MAPPER_PIPELINEGRCh38
GRCh371220,474,706 - 20,474,707RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS712165_HHumanblood high density lipoprotein cholesterol level  IAGPrs79719909405850206Based on the EFO term IDGWAS_CATALOGPMID:38448586
GWAS712165_HHumanblood total cholesterol level  IAGPrs79719909405850206Based on the EFO term IDGWAS_CATALOGPMID:38448586

Experimental Factor Annotations    Click to see Annotation Detail View
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
38610620LOC105369688uncharacterized LOC105369688122032081620328654Human

Position Markers

Peak: (rs79719909)
Human AssemblyChrPosition (strand)Source
GRCh381220,321,772 - 20,321,773RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407090049GWAS739025_Htotal cholesterol change measurement, high density lipoprotein cholesterol measurement QTL GWAS739025 (human)9e-11total cholesterol change measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407376267GWAS1025243_HHDL cholesterol change measurement, physical activity QTL GWAS1025243 (human)3e-08HDL cholesterol change measurement, physical activityblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407078571GWAS727547_Hphospholipids in large HDL measurement QTL GWAS727547 (human)2e-11phospholipids in large HDL measurementblood high density lipoprotein phospholipid level (CMO:0001565)122032177220321773Human
407414497GWAS1063473_Hhigh density lipoprotein cholesterol measurement QTL GWAS1063473 (human)2e-29high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
406914123GWAS563099_Hhigh density lipoprotein cholesterol measurement QTL GWAS563099 (human)5e-09high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407090921GWAS739897_Hfree cholesterol in large HDL measurement QTL GWAS739897 (human)6e-11free cholesterol in large HDL measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407414242GWAS1063218_Htriglyceride measurement QTL GWAS1063218 (human)1e-23triglyceride measurementblood triglyceride level (CMO:0000118)122032177220321773Human
407296680GWAS945656_Htriglyceride measurement QTL GWAS945656 (human)2e-16triglyceride measurementblood triglyceride level (CMO:0000118)122032177220321773Human
407296681GWAS945657_Htriglyceride measurement QTL GWAS945657 (human)3e-17triglyceride measurementblood triglyceride level (CMO:0000118)122032177220321773Human
407278036GWAS927012_Hhigh density lipoprotein cholesterol measurement QTL GWAS927012 (human)1e-17high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407078903GWAS727879_Hhigh density lipoprotein cholesterol measurement QTL GWAS727879 (human)8e-11high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407278034GWAS927010_Hhigh density lipoprotein cholesterol measurement QTL GWAS927010 (human)6e-17high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407063189GWAS712165_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS712165 (human)1e-10cholesterol esters in large HDL measurementblood high density lipoprotein cholesterol level (CMO:0000052)122032177220321773Human
407399442GWAS1048418_HBMI-adjusted waist-hip ratio QTL GWAS1048418 (human)4e-09BMI-adjusted waist-hip ratiohip circumference (CMO:0000014)122032177220321773Human
407090716GWAS739692_Htotal lipids in large HDL QTL GWAS739692 (human)7e-11total lipids in large HDL122032177220321773Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS563099_H GCST90278635 High density lipoprotein cholesterol levels 92,615 Taiwanese ancestry individuals ? NR 5E-9 8.302 rs79719909 N/A high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38116116
GWAS712165_H GCST90301971 Total cholesterol levels in HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.797 1E-10 10 rs79719909 0.0318 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
None Available GCST90301969 Total cholesterol in HDL2 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.7971 1E-10 10 rs79719909 0.0323 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS727547_H GCST90302003 Phospholipids in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.7968 2E-11 10.699 rs79719909 0.0342 phospholipids in large HDL measurement (EFO:0022190)
 PMID:38448586
GWAS727879_H GCST90302002 Concentration of large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.7968 8E-11 10.097 rs79719909 0.0331 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
None Available GCST90301997 Cholesterol esters in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.7968 1E-10 10 rs79719909 0.0328 cholesterol esters in large HDL measurement (EFO:0022159)
 PMID:38448586
GWAS739025_H GCST90301995 Total cholesterol in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.7968 9E-11 10.046 rs79719909 0.0331 total cholesterol change measurement (EFO:0007806)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS739692_H GCST90302001 Total lipids in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.7968 7E-11 10.155 rs79719909 0.0333 total lipids in large HDL (EFO:0022189)
 PMID:38448586
GWAS739897_H GCST90301999 Free cholesterol in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.7968 6E-11 10.222 rs79719909 0.0334 free cholesterol in large HDL measurement (EFO:0022157)
 PMID:38448586
GWAS927010_H GCST007140 High density lipoprotein cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals A 0.797 6E-17 16.222 rs79719909 0.039 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:29507422
GWAS927012_H GCST007140 High density lipoprotein cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals A NR 1E-17 17 rs79719909 0.037 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:29507422
GWAS945656_H GCST007142 Triglycerides 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals A 0.797 2E-16 15.699 rs79719909 0.042 triglyceride measurement (EFO:0004530)
 PMID:29507422
GWAS945657_H GCST007142 Triglycerides 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals A NR 3E-17 16.523 rs79719909 0.04 triglyceride measurement (EFO:0004530)
 PMID:29507422
GWAS1025243_H GCST007282 HDL cholesterol x physical activity interaction (2df test) 7,395 African American inactive individuals, 13,092 African American active individuals, 2,753 Asian ancestry inactive individuals, 3,650 Asian ancestry active individuals, 22,963 European ancestry inactive individuals, 61,939 European ancestry active individuals, 2,829 Hispanic or Latin American inactive individuals, 6,358 Hispanic or Latin American active individuals A 0.8073 3E-8 7.523 rs79719909 N/A HDL cholesterol change measurement (EFO:0007805)
physical activity (EFO:0003940)
 PMID:30670697
GWAS1048418_H GCST90020027 Waist-hip index 219,872 British ancestry women G NR 4E-9 8.398 rs79719909 0.0207988 BMI-adjusted waist-hip ratio (EFO:0007788)
 PMID:34021172
None Available GCST90020026 Hip index 219,872 British ancestry women G NR 4E-9 8.398 rs79719909 0.021637 BMI-adjusted hip circumference (EFO:0008039)
 PMID:34021172
None Available GCST90020025 Waist-to-hip ratio adjusted for BMI 219,872 British ancestry women G NR 4E-9 8.398 rs79719909 0.0208159 BMI-adjusted waist-hip ratio (EFO:0007788)
 PMID:34021172
GWAS1063218_H GCST90018975 Triglycerides 343,992 European ancestry individuals, 111,667 East Asian ancestry individuals G NR 1E-23 23 rs79719909 0.0263 triglyceride measurement (EFO:0004530)
 PMID:34594039
GWAS1063473_H GCST90018956 HDL cholesterol 315,133 European ancestry individuals, 74,970 East Asian ancestry individuals G NR 2E-29 28.699 rs79719909 0.0299 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:34594039
Database Acc Id Source(s)
GWAS Catalog GCST90301969 GWAS Catalog
  GCST90301971 GWAS Catalog
  GCST90301997 GWAS Catalog

RGD Curation Notes
Note Type Note Reference