GWAS689986_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS689986_H (total lipids in medium VLDL QTL GWAS689986 (human)) Homo sapiens

Symbol: GWAS689986_H
Name: total lipids in medium VLDL QTL GWAS689986 (human)
RGD ID: 407041010
Trait: total lipids in medium VLDL
LOD Score: Not Available
P Value: 4.0E-18
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh386160,565,883 - 160,565,884RGD_MAPPER_PIPELINEGRCh38
GRCh376160,986,915 - 160,986,916RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS689986_HHumantotal lipids in medium VLDL  IAGPrs6938647405850206 GWAS_CATALOGPMID:36764567
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1343679LPAlipoprotein(a)6160531482160664275Human

Position Markers

Peak: (rs6938647)
Human AssemblyChrPosition (strand)Source
GRCh386160,565,883 - 160,565,884RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406990402GWAS639378_Hlipoprotein A measurement QTL GWAS639378 (human)7e-119lipoprotein A measurement6160565883160565884Human
407039427GWAS688403_Hphospholipids in medium VLDL measurement QTL GWAS688403 (human)9e-15phospholipids in medium VLDL measurementblood very low density lipoprotein phospholipid level (CMO:0001571)6160565883160565884Human
407253764GWAS902740_Htotal cholesterol measurement QTL GWAS902740 (human)1e-08total cholesterol measurementblood total cholesterol level (CMO:0000051)6160565883160565884Human
407039180GWAS688156_Hvery low density lipoprotein cholesterol measurement QTL GWAS688156 (human)3e-16very low density lipoprotein cholesterol measurementblood very low density lipoprotein cholesterol level (CMO:0000648)6160565883160565884Human
407029260GWAS678236_Hcholesteryl ester measurement QTL GWAS678236 (human)3e-18blood lipid amount (VT:0003949)6160565883160565884Human
1643404BMD3_HBone mineral density QTL 3 (human)2.420.0005Bone mineral density6157563614170805979Human
407291859GWAS940835_Hremnant cholesterol measurement QTL GWAS940835 (human)2e-09remnant cholesterol measurement6160565883160565884Human
407037652GWAS686628_Hcholesterol in small LDL measurement QTL GWAS686628 (human)1e-09cholesterol in small LDL measurement 6160565883160565884Human
407035355GWAS684331_Hcholesteryl ester measurement QTL GWAS684331 (human)6e-14blood lipid amount (VT:0003949)6160565883160565884Human
407033823GWAS682799_Hcholesterol in large VLDL measurement QTL GWAS682799 (human)5e-18cholesterol in large VLDL measurement 6160565883160565884Human
407194971GWAS843947_Hlow density lipoprotein cholesterol measurement QTL GWAS843947 (human)9e-09low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)6160565883160565884Human
407323864GWAS972840_Hlow density lipoprotein cholesterol measurement QTL GWAS972840 (human)1e-12low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)6160565883160565884Human
407286439GWAS935415_Htotal cholesterol measurement, very low density lipoprotein cholesterol measurement QTL GWAS935415 (human)1e-10total cholesterol measurement, very low density lipoprotein cholesterol measurementblood very low density lipoprotein cholesterol level (CMO:0000648)6160565883160565884Human
407076513GWAS725489_Hcomplex trait QTL GWAS725489 (human)4e-09complex trait6160565883160565884Human
407326948GWAS975924_Hlow density lipoprotein cholesterol measurement, phospholipid measurement QTL GWAS975924 (human)6e-11low density lipoprotein cholesterol measurement, phospholipid measurementblood low density lipoprotein cholesterol level (CMO:0000053)6160565883160565884Human
407029479GWAS678455_Hlinoleic acid measurement QTL GWAS678455 (human)1e-17linoleic acid measurementblood free fatty acids level (CMO:0000117)6160565883160565884Human
407024356GWAS673332_Hcholesteryl esters to total lipids in large LDL percentage QTL GWAS673332 (human)2e-12low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)6160565883160565884Human
407032164GWAS681140_Hfree cholesterol in VLDL measurement QTL GWAS681140 (human)6e-20free cholesterol in VLDL measurement 6160565883160565884Human
407029356GWAS678332_Homega-6 polyunsaturated fatty acid measurement QTL GWAS678332 (human)3e-15omega-6 polyunsaturated fatty acid measurement6160565883160565884Human
407112235GWAS761211_Hphospholipids in VLDL measurement QTL GWAS761211 (human)6e-21phospholipids in VLDL measurement 6160565883160565884Human
407041010GWAS689986_Htotal lipids in medium VLDL QTL GWAS689986 (human)4e-18total lipids in medium VLDL6160565883160565884Human
407040304GWAS689280_Htotal lipids in lipoprotein particles measurement QTL GWAS689280 (human)3e-14total lipids in lipoprotein particles measurement 6160565883160565884Human
406990648GWAS639624_Hlipoprotein A measurement, apolipoprotein A 1 measurement QTL GWAS639624 (human)2e-87lipoprotein A measurement, apolipoprotein A 1 measurementblood apolipoprotein AI level (CMO:0000520)6160565883160565884Human
407037816GWAS686792_Hlow density lipoprotein cholesterol measurement QTL GWAS686792 (human)2e-14milk polyunsaturated fatty acid amount (VT:0010374)milk polyunsaturated fatty acid measurement (CMO:0000821)6160565883160565884Human
407190270GWAS839246_Hcholesteryl ester measurement, low density lipoprotein cholesterol measurement QTL GWAS839246 (human)3e-09blood lipid amount (VT:0003949)blood low density lipoprotein cholesterol level (CMO:0000053)6160565883160565884Human
1643367BW323_HBody weight QTL 323 (human)2.420.0005Body fat amount6157563614170805979Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS639378_H GCST004398 Lipoprotein (a) levels 13,781 European ancestry individuals A NR 7E-119 118.155 rs6938647 5.47 lipoprotein A measurement (EFO:0006925)
 PMID:28512139
GWAS639624_H GCST004399 Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms 13,781 European ancestry individuals A NR 2E-87 86.699 rs6938647 5.48 lipoprotein A measurement (EFO:0006925)
apolipoprotein A 1 measurement (EFO:0004614)
 PMID:28512139
GWAS673332_H GCST90269713 Cholesteryl esters to total lipids in large LDL percentage (UKB data field 23616) 88,329 European ancestry individuals A 0.219242 2E-12 11.699 rs6938647 0.0407934 cholesteryl esters to total lipids in large LDL percentage (EFO:0022249)
 PMID:36764567
GWAS678236_H GCST90269589 Cholesteryl esters in very large VLDL (UKB data field 23492) 88,329 European ancestry individuals A 0.219242 3E-18 17.523 rs6938647 0.0497655 cholesteryl ester measurement (EFO:0010351)
 PMID:36764567
GWAS678332_H GCST90269542 Omega-6 fatty acids levels (UKB data field 23445) 88,268 European ancestry individuals A 0.219214 3E-15 14.523 rs6938647 0.0446658 omega-6 polyunsaturated fatty acid measurement (EFO:0005680)
 PMID:36764567
GWAS678455_H GCST90269546 Linoleic acid levels (UKB data field 23449) 88,268 European ancestry individuals A 0.219214 1E-17 17 rs6938647 0.048551 linoleic acid measurement (EFO:0006807)
 PMID:36764567
GWAS681140_H GCST90269517 Free cholesterol in VLDL (UKB data field 23420) 88,329 European ancestry individuals A 0.219242 6E-20 19.222 rs6938647 0.0525152 free cholesterol in VLDL measurement (EFO:0022276)
 PMID:36764567
GWAS682799_H GCST90269595 Cholesterol in large VLDL (UKB data field 23498) 88,329 European ancestry individuals A 0.219242 5E-18 17.302 rs6938647 0.049054 cholesterol in large VLDL measurement (EFO:0021902)
 PMID:36764567
GWAS684331_H GCST90269596 Cholesteryl esters in large VLDL (UKB data field 23499) 88,329 European ancestry individuals A 0.219242 6E-14 13.222 rs6938647 0.0429533 cholesteryl ester measurement (EFO:0010351)
 PMID:36764567
GWAS686628_H GCST90269644 Cholesterol in small LDL (UKB data field 23547) 88,329 European ancestry individuals A 0.219242 1E-9 9 rs6938647 0.0353692 cholesterol in small LDL measurement (EFO:0022227)
 PMID:36764567
GWAS686792_H GCST90269641 Concentration of small LDL particles (UKB data field 23544) 88,329 European ancestry individuals A 0.219242 2E-14 13.699 rs6938647 0.0444247 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:36764567
GWAS688156_H GCST90269599 Concentration of medium VLDL particles (UKB data field 23502) 88,329 European ancestry individuals A 0.219242 3E-16 15.523 rs6938647 0.0473593 very low density lipoprotein cholesterol measurement (EFO:0008317)
 PMID:36764567
GWAS688403_H GCST90269601 Phospholipids in medium VLDL (UKB data field 23504) 88,329 European ancestry individuals A 0.219242 9E-15 14.046 rs6938647 0.0448098 phospholipids in medium VLDL measurement (EFO:0022154)
 PMID:36764567
GWAS689280_H GCST90269520 Total lipids in lipoprotein particles (UKB data field 23423) 88,329 European ancestry individuals A 0.219242 3E-14 13.523 rs6938647 0.0433015 total lipids in lipoprotein particles measurement (EFO:0022309)
 PMID:36764567
None Available GCST90269543 Polyunsaturated fatty acids levels (UKB data field 23446) 88,268 European ancestry individuals A 0.219214 2E-14 13.699 rs6938647 0.0432762 polyunsaturated fatty acid measurement (EFO:0010733)
 PMID:36764567
GWAS689986_H GCST90269600 Total lipids in medium VLDL (UKB data field 23503) 88,329 European ancestry individuals A 0.219242 4E-18 17.398 rs6938647 0.0500117 total lipids in medium VLDL (EFO:0022153)
 PMID:36764567
None Available GCST90269634 Concentration of medium LDL particles (UKB data field 23537) 88,329 European ancestry individuals A 0.219242 2E-12 11.699 rs6938647 0.0409272 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:36764567
GWAS725489_H GCST90270119 Multi-trait sum score 141,980 European ancestry males ? NR 4E-9 8.398 rs6938647 N/A complex trait (EFO:0010578)
 PMID:37277458
GWAS761211_H GCST90269509 Phospholipids in VLDL (UKB data field 23412) 88,329 European ancestry individuals A 0.219242 6E-21 20.222 rs6938647 0.0536891 phospholipids in VLDL measurement (EFO:0022301)
 PMID:36764567
GWAS839246_H GCST90092884 Cholesteryl ester levels in LDL 115,082 European ancestry individuals A 0.21767 3E-9 8.523 rs6938647 0.029975 cholesteryl ester measurement (EFO:0010351)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS843947_H GCST90092863 Concentration of large LDL particles 115,082 European ancestry individuals A 0.21767 9E-9 8.046 rs6938647 0.0289852 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS902740_H GCST90092930 Total cholesterol minus HDL-C levels 115,082 European ancestry individuals A 0.21767 1E-8 8 rs6938647 0.0286903 total cholesterol measurement (EFO:0004574)
 PMID:35213538
GWAS935415_H GCST90092916 Cholesterol levels in medium VLDL 115,082 European ancestry individuals A 0.21767 1E-10 10 rs6938647 0.0323992 total cholesterol measurement (EFO:0004574)
very low density lipoprotein cholesterol measurement (EFO:0008317)
 PMID:35213538
GWAS940835_H GCST90092943 Remnant cholesterol (non-HDL, non-LDL -cholesterol) 115,082 European ancestry individuals A 0.21767 2E-9 8.699 rs6938647 0.0302519 remnant cholesterol measurement (EFO:0010815)
 PMID:35213538
None Available GCST90092985 Total cholesterol levels 115,082 European ancestry individuals A 0.21767 1E-8 8 rs6938647 0.0279905 total cholesterol measurement (EFO:0004574)
 PMID:35213538
GWAS972840_H GCST90179148 Low-density lipoprotein levels (MTAG) 361,194 European ancestry individuals A NR 1E-12 12 rs6938647 0.011905 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:36376304
GWAS975924_H GCST90092964 Phospholipid levels in small LDL 115,082 European ancestry individuals A 0.21767 6E-11 10.222 rs6938647 0.0331085 low density lipoprotein cholesterol measurement (EFO:0004611)
phospholipid measurement (EFO:0004639)
 PMID:35213538
None Available GCST90446535 Cardiovascular disease 44,238 European ancestry cases, 414,900 European ancestry controls ? NR 6E-13 12.222 rs6938647 N/A cardiovascular disease (EFO:0000319)
 PMID:37947095
None Available GCST90446534 Coronary heart disease 38,687 European ancestry cases, 420,451 European ancestry controls ? NR 5E-15 14.302 rs6938647 N/A coronary artery disease (EFO:0001645)
 PMID:37947095
Database Acc Id Source(s)
GWAS Catalog GCST90269600 GWAS Catalog

RGD Curation Notes
Note Type Note Reference