GWAS638598_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS638598_H (response to tenofovir, creatinine clearance measurement QTL GWAS638598 (human)) Homo sapiens

Symbol: GWAS638598_H
Name: response to tenofovir, creatinine clearance measurement QTL GWAS638598 (human)
RGD ID: 406989622
Trait: response to tenofovir, creatinine clearance measurement
Measurement Type: creatinine clearance   (CMO:0000765)    
LOD Score: Not Available
P Value: 8.0E-6
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381524,925,023 - 24,925,024RGD_MAPPER_PIPELINEGRCh38
GRCh371525,170,170 - 25,170,171RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS638598_HHumancreatinine clearance  IAGPrs12592731405850206Based on the EFO term IDGWAS_CATALOGPMID:26148204

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS638598_HHumancreatinine clearance measurement  IAGPrs12592731405850206 GWAS_CATALOGPMID:26148204
GWAS638598_HHumanresponse to tenofovir  IAGPrs12592731405850206 GWAS_CATALOGPMID:26148204
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
12798467SNHG14small nucleolar RNA host gene 14152482360825419462Human
1343749SNRPNsmall nuclear ribonucleoprotein polypeptide N152482363724978723Human

Position Markers

Peak: (rs12592731)
Human AssemblyChrPosition (strand)Source
GRCh381524,925,023 - 24,925,024RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2289410BW327_HBody weight QTL 327 (human)3.320.0001Body fat amount151998012945980129Human
2289430BMD7_HBone mineral density QTL 7 (human)3.320.0001Bone mineral density151998012945980129Human
406989622GWAS638598_Hresponse to tenofovir, creatinine clearance measurement QTL GWAS638598 (human)0.000008response to tenofovir, creatinine clearance measurementcreatinine clearance (CMO:0000765)152492502324925024Human
1643523BW284_HBody Weight QTL 284 (human)1.950.0013Body weight152179288947792889Human
2289420BW314_HBody weight QTL 314 (human)2.720.0003Body weightlean mass151998012945980129Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS638598_H GCST006069 Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction) 243 European American ancestry tenofovir-treated cases, 149 African American tenofovir-treated cases, 100 Hispanic American tenofovir-treated cases, 9 unknown ancestry tenofovir-treated cases, 243 European American ancestry abacavir-treated cases, 189 African American abacavir-treated cases, 102 Hispanic American abacavir-treated cases, 14 unknown ancestry abacavir-treated cases. ? NR 0.000008 5.097 rs12592731 N/A response to tenofovir (EFO:0009279)
creatinine clearance measurement (EFO:0007934)
 PMID:26148204
Database Acc Id Source(s)
GWAS Catalog GCST006069 GWAS Catalog

RGD Curation Notes
Note Type Note Reference