GWAS619625_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS619625_H (eosinophil percentage of leukocytes QTL GWAS619625 (human)) Homo sapiens

Symbol: GWAS619625_H
Name: eosinophil percentage of leukocytes QTL GWAS619625 (human)
RGD ID: 406970649
Trait: eosinophil percentage of leukocytes
Measurement Type: blood eosinophil count to total leukocyte count ratio   (CMO:0000369)    
LOD Score: Not Available
P Value: 5.0E-15
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38191,104,079 - 1,104,080RGD_MAPPER_PIPELINEGRCh38
GRCh37191,104,078 - 1,104,079RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS619625_HHumanblood eosinophil count to total leukocyte count ratio  IAGPrs4807542405850206Based on the EFO term IDGWAS_CATALOGPMID:27863252

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS619625_HHumaneosinophil percentage of leukocytes  IAGPrs4807542405850206 GWAS_CATALOGPMID:27863252
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
329841360LOC130062887ATAC-STARR-seq lymphoblastoid silent region 96651911038101104829Human
736049GPX4glutathione peroxidase 41911039941106779Human

Position Markers

Peak: (rs4807542)
Human AssemblyChrPosition (strand)Source
GRCh38191,104,079 - 1,104,080RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1643451SLIPL6_HSerum lipid level QTL 6 (human)2.190.0008Lipid level19116075902Human
1581534BP76_HBlood pressure QTL 76 (human)20.001Blood pressurepulse pressure19116075902Human
1581535BP65_HBlood pressure QTL 65 (human)3.10.001Blood pressurepulse pressure19116075902Human
407060324GWAS709300_HNasal Cavity Polyp QTL GWAS709300 (human)8e-08Nasal Cavity Polyp1911040791104080Human
406939723GWAS588699_Heosinophil count QTL GWAS588699 (human)2e-21eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1911040791104080Human
406964655GWAS613631_Hneutrophil percentage of granulocytes QTL GWAS613631 (human)5e-09neutrophil percentage of granulocytes1911040791104080Human
406938607GWAS587583_Heosinophil percentage of leukocytes QTL GWAS587583 (human)3e-25eosinophil percentage of leukocytesblood eosinophil count to total leukocyte count ratio (CMO:0000369)1911040791104080Human
406953902GWAS602878_Heosinophil count QTL GWAS602878 (human)1e-11eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1911040791104080Human
1298499UAE1_HUrinary albumin excretion QTL 1 (human)2.730.0009Urinary albumin excretionurine albumin:creatinine ratio (ACR)19116075902Human
406967122GWAS616098_Hbasophil count, eosinophil count QTL GWAS616098 (human)2e-09eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1911040791104080Human
407215037GWAS864013_HNasal Cavity Polyp QTL GWAS864013 (human)1e-08Nasal Cavity Polyp1911040791104080Human
406970649GWAS619625_Heosinophil percentage of leukocytes QTL GWAS619625 (human)5e-15eosinophil percentage of leukocytesblood eosinophil count to total leukocyte count ratio (CMO:0000369)1911040791104080Human
2314591INSUL4_HInsulin level QTL 4 (human)3.80.000038Insulin levelfasting19116075902Human
406973247GWAS622223_Heosinophil percentage of granulocytes QTL GWAS622223 (human)3e-11eosinophil percentage of granulocytes1911040791104080Human
1298476BP3_HBlood pressure QTL 3 (human)2.4Blood pressuresystolic19116075902Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS587583_H GCST90002382 Eosinophil percentage of white cells 408,112 British individuals A 0.16662 3E-25 24.523 rs4807542 0.031508792 eosinophil percentage of leukocytes (EFO:0007991)
 PMID:32888494
GWAS588699_H GCST90002381 Eosinophil counts 408,112 British individuals A 0.166606 2E-21 20.699 rs4807542 0.028435826 eosinophil count (EFO:0004842)
 PMID:32888494
GWAS602878_H GCST004606 Eosinophil counts 172,275 European ancestry individuals A 0.1694 1E-11 11 rs4807542 0.0327061 eosinophil count (EFO:0004842)
 PMID:27863252
GWAS613631_H GCST004623 Neutrophil percentage of granulocytes 170,672 European ancestry individuals A 0.1693 5E-9 8.302 rs4807542 0.02821863 neutrophil percentage of granulocytes (EFO:0007994)
 PMID:27863252
GWAS616098_H GCST004624 Sum eosinophil basophil counts 171,771 European ancestry individuals A 0.1694 2E-9 8.699 rs4807542 0.02894799 basophil count (EFO:0005090)
eosinophil count (EFO:0004842)
 PMID:27863252
GWAS619625_H GCST004600 Eosinophil percentage of white cells 172,378 European ancestry individuals A 0.1694 5E-15 14.302 rs4807542 0.03752435 eosinophil percentage of leukocytes (EFO:0007991)
 PMID:27863252
GWAS622223_H GCST004617 Eosinophil percentage of granulocytes 170,536 European ancestry individuals A 0.1693 3E-11 10.523 rs4807542 0.0321279 eosinophil percentage of granulocytes (EFO:0007996)
 PMID:27863252
GWAS709300_H GCST007443 Nasal polyps 86 European ancestry whole-genome sequenced cases, 4,280 European ancestry cases, 13,941 European ancestry whole-genome sequenced controls, 700,740 European ancestry controls G 0.835 8E-8 7.097 rs4807542 1.1904762 Nasal Cavity Polyp (EFO:1000391)
 PMID:30643255
GWAS864013_H GCST90018883 Nasal polyps 5,093 European ancestry cases, 444,966 European ancestry controls, 160 East Asian ancestry cases, 151,846 East Asian ancestry controls A NR 1E-8 8 rs4807542 0.1478 Nasal Cavity Polyp (EFO:1000391)
 PMID:34594039
Database Acc Id Source(s)
GWAS Catalog GCST004600 GWAS Catalog

RGD Curation Notes
Note Type Note Reference