GWAS589206_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS589206_H (protein measurement QTL GWAS589206 (human)) Homo sapiens

Symbol: GWAS589206_H
Name: protein measurement QTL GWAS589206 (human)
RGD ID: 406940230
Trait: protein measurement
LOD Score: Not Available
P Value: 1.0E-46
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381944,913,034 - 44,913,035RGD_MAPPER_PIPELINEGRCh38
GRCh371945,416,291 - 45,416,292RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS589206_HHumanprotein measurement  IAGPrs59325138405850206 GWAS_CATALOGPMID:34648354
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
155765829LOC127891702H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45415901-45416660194491264444913403Human

Position Markers

Peak: (rs59325138)
Human AssemblyChrPosition (strand)Source
GRCh381944,913,034 - 44,913,035RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407076243GWAS725219_Hcomplex trait QTL GWAS725219 (human)1e-17complex trait194491303444913035Human
406953553GWAS602529_Hprotein measurement QTL GWAS602529 (human)4e-21protein measurement194491303444913035Human
1559110SCL22_HSerum cholesterol level QTL 22 (human)3.590.000241Lipid levelLDL cholesterol193190759457907594Human
407270275GWAS919251_Hlow density lipoprotein cholesterol measurement QTL GWAS919251 (human)9e-15low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)194491303444913035Human
406952980GWAS601956_Hprotein measurement QTL GWAS601956 (human)1e-37protein measurement194491303444913035Human
406940230GWAS589206_Hprotein measurement QTL GWAS589206 (human)1e-46protein measurement194491303444913035Human
407268670GWAS917646_Htotal cholesterol measurement QTL GWAS917646 (human)4e-11total cholesterol measurementblood total cholesterol level (CMO:0000051)194491303444913035Human
407142189GWAS791165_HAlzheimer disease, family history of Alzheimer’s disease QTL GWAS791165 (human)5e-08Alzheimer disease, family history of Alzheimer’s disease194491303444913035Human
1331657COPD9_HChronic obstructive pulmonary disease QTL 9 (human)1.94Chronic airflow obstructionpost-bronchodilator FEV1193102176057021760Human
407138857GWAS787833_Hcomplex trait QTL GWAS787833 (human)6e-14complex trait194491303444913035Human
406940172GWAS589148_Hprotein measurement QTL GWAS589148 (human)4e-24protein measurement194491303444913035Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS589148_H GCST90246564 ADP-ribosylation factor GTPase-activating protein 1 levels 10,708 European ancestry individuals T 0.4 4E-24 23.398 rs59325138 0.138 protein measurement (EFO:0004747)
 PMID:34648354
GWAS589206_H GCST90250094 UDP-glucose 4-epimerase levels 10,708 European ancestry individuals T 0.4 1E-46 46 rs59325138 0.196 protein measurement (EFO:0004747)
 PMID:34648354
GWAS601956_H GCST90249715 Stromelysin-1 levels 10,708 European ancestry individuals T 0.4 1E-37 37 rs59325138 0.179 protein measurement (EFO:0004747)
 PMID:34648354
GWAS602529_H GCST90249725 Syntaxin-binding protein 6 levels 10,708 European ancestry individuals T 0.4 4E-21 20.398 rs59325138 0.127 protein measurement (EFO:0004747)
 PMID:34648354
GWAS725219_H GCST90270119 Multi-trait sum score 141,980 European ancestry males ? NR 1E-17 17 rs59325138 N/A complex trait (EFO:0010578)
 PMID:37277458
GWAS787833_H GCST90270117 Multi-trait sum score 161,906 European ancestry females ? NR 6E-14 13.222 rs59325138 N/A complex trait (EFO:0010578)
 PMID:37277458
GWAS791165_H GCST005922 Alzheimer's disease or family history of Alzheimer's disease up to 42,034 British ancestry individuals with parental history of Alzheimer's disease, at least 272,244 British ancestry individuals with no parental history of Alzheimer's disease, 25,580 Alzheimer's disease cases, 48,466 controls ? NR 5E-8 7.302 rs59325138 N/A family history of Alzheimer’s disease (EFO:0009268)
 PMID:29777097
GWAS917646_H GCST90090991 Total cholesterol levels 17,701 African American individuals, 22,954 Hispanics ancestry individuals, 2,387 East Asian ancestry individuals, 1,915 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 340 individuals, 22,912 European ancestry individuals ? NR 4E-11 10.398 rs59325138 0.057 total cholesterol measurement (EFO:0004574)
 PMID:32226016
GWAS919251_H GCST90090990 Low density lipoprotein cholesterol levels 17,222 African American individuals, 22,406 Hispanics ancestry individuals, 2,316 East Asian ancestry individuals, 1,900 Native Hawaiian ancestry individuals, 591 Native American ancestry individuals, 321 individuals, 22,331 European ancestry individuals ? NR 9E-15 14.046 rs59325138 0.068 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:32226016
None Available GCST90448433 Baseline memory 13,154 European ancestry females ? NR 2E-13 12.699 rs59325138 0.065595 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448452 Memory decline in impaired cognition 4,478 European ancestry males ? NR 5E-13 12.302 rs59325138 0.016804 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448431 Baseline memory in impaired cognition 869 African ancestry females ? NR 0.000007 5.155 rs59325138 0.180132 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448425 Baseline memory in impaired cognition 4,478 European ancestry males ? NR 9E-8 7.046 rs59325138 0.085892 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448430 Baseline memory 2,487 African ancestry females ? NR 8E-10 9.097 rs59325138 0.128964 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448451 Memory decline 11,062 European ancestry males ? NR 4E-15 14.398 rs59325138 0.008497 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448418 Baseline memory 11,062 European ancestry males, 880 African ancestry males ? NR 1E-17 17 rs59325138 0.079108 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448419 Baseline memory in impaired cognition 4,478 European ancestry males, 373 African ancestry males ? NR 3E-8 7.523 rs59325138 0.086493 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448428 Baseline memory in impaired cognition 3,987 European ancestry females, 869 African ancestry females ? NR 4E-11 10.398 rs59325138 0.113376 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448424 Baseline memory 11,062 European ancestry males ? NR 1E-15 15 rs59325138 0.076615 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448454 Memory decline 13,154 European ancestry females, 2,487 African ancestry females ? NR 2E-18 17.699 rs59325138 0.008466 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448445 Memory decline 11,062 European ancestry males, 880 African ancestry males ? NR 6E-16 15.222 rs59325138 0.008567 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448427 Baseline memory 13,154 European ancestry females, 2,487 African ancestry females ? NR 5E-20 19.302 rs59325138 0.075311 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448434 Baseline memory in impaired cognition 3,987 European ancestry females ? NR 2E-7 6.699 rs59325138 0.098481 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448460 Memory decline 13,154 European ancestry females ? NR 4E-15 14.398 rs59325138 0.008153 memory performance (EFO:0004874)
 PMID:37984853
None Available GCST90448446 Memory decline in impaired cognition 4,478 European ancestry males, 373 African ancestry males ? NR 6E-14 13.222 rs59325138 0.016971 memory performance (EFO:0004874)
 PMID:37984853
Database Acc Id Source(s)
GWAS Catalog GCST90250094 GWAS Catalog

RGD Curation Notes
Note Type Note Reference