GWAS579477_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS579477_H (alcohol consumption measurement QTL GWAS579477 (human)) Homo sapiens

Symbol: GWAS579477_H
Name: alcohol consumption measurement QTL GWAS579477 (human)
RGD ID: 406930501
Trait: alcohol consumption measurement
Measurement Type: ethanol drink intake rate   (CMO:0001407)    
LOD Score: Not Available
P Value: 2E-160
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38439,413,373 - 39,413,374RGD_MAPPER_PIPELINEGRCh38
GRCh37439,414,993 - 39,414,994RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS579477_HHumanethanol drink intake rate  IAGPrs11940694405850206Based on the EFO term IDGWAS_CATALOGPMID:36477530

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS579477_HHumanalcohol consumption measurement  IAGPrs11940694405850206 GWAS_CATALOGPMID:36477530
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1604985KLBklotho beta43940693039451533Human

Position Markers

Peak: (rs11940694)
Human AssemblyChrPosition (strand)Source
GRCh38439,413,373 - 39,413,374RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406905152GWAS554128_Halcohol consumption measurement QTL GWAS554128 (human)2e-11alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406985798GWAS634774_Hbitter alcoholic beverage consumption measurement QTL GWAS634774 (human)4e-33bitter alcoholic beverage consumption measurementdrink intake measurement (CMO:0000771)43941337339413374Human
406930501GWAS579477_Halcohol consumption measurement QTL GWAS579477 (human)2e-160alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406905157GWAS554133_Halcohol drinking QTL GWAS554133 (human)0.0000007alcohol drinking43941337339413374Human
406902021GWAS550997_Halcohol consumption measurement QTL GWAS550997 (human)8e-19alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
407009861GWAS658837_Hprotein intake measurement QTL GWAS658837 (human)1e-14eating behavior trait (VT:0001431)43941337339413374Human
407341773GWAS990749_Hurate measurement QTL GWAS990749 (human)3e-10urate measurementblood uric acid level (CMO:0000501)43941337339413374Human
407253258GWAS902234_Hfatty acid measurement QTL GWAS902234 (human)1e-08fatty acid measurement43941337339413374Human
406929612GWAS578588_Halcohol consumption measurement QTL GWAS578588 (human)6e-21alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406902032GWAS551008_Halcohol consumption measurement QTL GWAS551008 (human)6e-18alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406900625GWAS549601_Halcohol consumption measurement, alcohol drinking QTL GWAS549601 (human)0.0000001alcohol consumption measurement, alcohol drinkingethanol drink intake rate (CMO:0001407)43941337339413374Human
407075474GWAS724450_Hblood urea nitrogen measurement QTL GWAS724450 (human)3e-12blood urea nitrogen measurementblood urea nitrogen level (CMO:0000049)43941337339413374Human
406970194GWAS619170_Halcohol consumption measurement QTL GWAS619170 (human)9e-12alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406901974GWAS550950_Halcohol consumption measurement QTL GWAS550950 (human)9e-10alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
407117458GWAS766434_Halcohol consumption measurement QTL GWAS766434 (human)4e-64alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
407024154GWAS673130_Halcohol consumption measurement QTL GWAS673130 (human)9e-188alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
407291423GWAS940399_Hphospholipid measurement, high density lipoprotein cholesterol measurement QTL GWAS940399 (human)8e-10lipid measurement, high density lipoprotein cholesterol measurementblood lipid measurement (CMO:0000050)43941337339413374Human
406934746GWAS583722_Halcohol consumption measurement QTL GWAS583722 (human)0.000004alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406991260GWAS640236_Halcohol consumption measurement QTL GWAS640236 (human)5e-17alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406981283GWAS630259_Halcohol consumption measurement QTL GWAS630259 (human)3e-68alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
406991267GWAS640243_Halcohol dependence measurement QTL GWAS640243 (human)1e-09free cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)43941337339413374Human
406904997GWAS553973_Halcohol consumption measurement QTL GWAS553973 (human)4e-08urate measurementblood uric acid level (CMO:0000501)43941337339413374Human
407325292GWAS974268_Halcohol consumption measurement QTL GWAS974268 (human)7e-62alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
407255210GWAS904186_Hfatty acid measurement QTL GWAS904186 (human)2e-09fatty acid measurement43941337339413374Human
406991215GWAS640191_Halcohol use disorder measurement QTL GWAS640191 (human)7e-21alcohol use disorder measurement43941337339413374Human
407116150GWAS765126_Halcohol consumption measurement QTL GWAS765126 (human)3e-41alcohol consumption measurementethanol drink intake rate (CMO:0001407)43941337339413374Human
407335728GWAS984704_Huric acid measurement QTL GWAS984704 (human)4e-09uric acid measurementblood uric acid level (CMO:0000501)43941337339413374Human
407170239GWAS819215_Hserum gamma-glutamyl transferase measurement QTL GWAS819215 (human)3e-23serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)43941337339413374Human
407016895GWAS665871_Hurate measurement QTL GWAS665871 (human)2e-08urate measurementblood uric acid level (CMO:0000501)43941337339413374Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS549601_H GCST004405 Alcohol consumption (drinks per week) 23,104 European ancestry non-drinker individuals, 47,967 European ancestry drinker individuals, 2,673 Hispanic/Latino non-drinker individuals, 4,374 Hispanic/Latino drinker individuals, 3,288 East Asian ancestry non-drinker individuals, 2,746 East Asian ancestry drinker individuals, 1,165 African American non-drinkers individuals, 1,310 African American drinker individuals.        A 0.42 1E-7 7 rs11940694 0.035 alcohol consumption measurement (EFO:0007878)
alcohol drinking (EFO:0004329)
 PMID:28485404
GWAS550950_H GCST004886 Alcohol consumption 59,088 European ancestry females, 53,029 European ancestry males A 0.39 9E-10 9.046 rs11940694 0.026 alcohol consumption measurement (EFO:0007878)
 PMID:28937693
GWAS550997_H GCST004886 Alcohol consumption 59,088 European ancestry females, 53,029 European ancestry males A 0.39 8E-19 18.097 rs11940694 0.027 alcohol consumption measurement (EFO:0007878)
 PMID:28937693
GWAS551008_H GCST004887 Alcohol consumption in current drinkers 108,309 European ancestry individuals A 0.39 6E-18 17.222 rs11940694 0.027 alcohol consumption measurement (EFO:0007878)
 PMID:28937693
GWAS553973_H GCST90319889 Daily alcohol intake 154,570 Japanese ancestry individuals ? NR 4E-8 7.398 rs11940694 0.04 alcohol consumption measurement (EFO:0007878)
 PMID:38277453
GWAS554128_H GCST90319891 Daily alcohol intake in rs671 GG genotype 87,980 Japanese ancestry individuals ? NR 2E-11 10.699 rs11940694 0.06 alcohol consumption measurement (EFO:0007878)
 PMID:38277453
GWAS554133_H GCST90319892 Alcohol drinking status in rs671 GG genotype 64,727 Japanese ancestry ever-drinkers, 37,306 Japanese ancestry never-drinkers ? NR 7E-7 6.155 rs11940694 1.06 alcohol drinking (EFO:0004329)
 PMID:38277453
GWAS578588_H GCST90243982 Drinks per week 274,707 Hispanic or Latin American individuals G 0.5062 6E-21 20.222 rs11940694 0.0254 alcohol consumption measurement (EFO:0007878)
 PMID:36477530
GWAS579477_H GCST90243984 Drinks per week 2,428,851 European ancestry individuals G 0.592 2E-160 159.699 rs11940694 0.0249 alcohol consumption measurement (EFO:0007878)
 PMID:36477530
GWAS583722_H GCST009800 Alcohol consumption (drinks per week) 58,610 Japanese ancestry individuals ? NR 0.000004 5.398 rs11940694 0.027 alcohol consumption measurement (EFO:0007878)
 PMID:31959922
GWAS619170_H GCST004026 Alcohol consumption up to 70,460 European ancestry drinker individuals A 0.42 9E-12 11.046 rs11940694 0.0136 alcohol consumption measurement (EFO:0007878)
 PMID:27911795
GWAS630259_H GCST008757 Alcohol consumption 480,842 European ancestry individuals A 0.3938 3E-68 67.523 rs11940694 0.0185 alcohol consumption measurement (EFO:0007878)
 PMID:31358974
GWAS634774_H GCST008522 Bitter alcoholic beverage consumption 336,448 European ancestry individuals G 0.6023 4E-33 32.398 rs11940694 0.0125 bitter alcoholic beverage consumption measurement (EFO:0010092)
 PMID:31046077
GWAS640191_H GCST006716 Alcohol use disorder (total score) 141,932 European ancestry individuals A NR 7E-21 20.155 rs11940694 9.38 alcohol use disorder measurement (EFO:0009458)
 PMID:30336701
GWAS640236_H GCST006718 Alcohol use disorder (consumption score) 121,604 British ancestry individuals G NR 5E-17 16.302 rs11940694 0.009 alcohol consumption measurement (EFO:0007878)
 PMID:30336701
GWAS640243_H GCST006717 Alcohol use disorder (dependence and problematic use scores) 121,604 British ancestry individuals G NR 1E-9 9 rs11940694 0.007 alcohol dependence measurement (EFO:0007835)
 PMID:30336701
GWAS658837_H GCST010498 Relative protein intake 175,253 European ancestry individuals ? NR 1E-14 14 rs11940694 0.022 protein intake measurement (EFO:0010810)
 PMID:32393786
GWAS665871_H GCST008972 Urate levels 288,649 European ancestry individuals, 125,725 East Asian ancestry individuals, 33,671 African American individuals, 9,037 South Asian ancestry individuals, 608 Hispanic individuals A 0.4643 2E-8 7.699 rs11940694 0.0173 urate measurement (EFO:0004531)
 PMID:31578528
GWAS673130_H GCST90243989 Drinks per week 2,965,643 European ancestry, East Asian ancestry, Hispanic or Latin American, African ancestry individuals G 0.575 9E-188 187.046 rs11940694 0.0243 alcohol consumption measurement (EFO:0007878)
 PMID:36477530
None Available GCST011119 Urate levels 454,183 European ancestry individuals A 0.39 4E-8 7.398 rs11940694 0.0103 urate measurement (EFO:0004531)
 PMID:33356394
GWAS724450_H GCST008062 Blood urea nitrogen levels 416,178 European and unknown ancestry individuals A 0.4654 3E-12 11.523 rs11940694 0.0048 blood urea nitrogen measurement (EFO:0004741)
 PMID:31152163
GWAS765126_H GCST007328 Alcohol consumption (drinks per week) 414,343 European ancestry individuals A 0.3928 3E-41 40.523 rs11940694 0.030738968 alcohol consumption measurement (EFO:0007878)
 PMID:30643258
GWAS766434_H GCST007472 Alcohol consumption (drinks per week) (MTAG) up to 1,039,210 European ancestry individuals G 0.597 4E-64 63.398 rs11940694 0.0228615 alcohol consumption measurement (EFO:0007878)
 PMID:30643251
None Available GCST007461 Alcohol consumption (drinks per week) up to 941,280 European ancestry individuals G 0.597 3E-68 67.523 rs11940694 0.025949908 alcohol consumption measurement (EFO:0007878)
 PMID:30643251
None Available GCST90309356 Alcohol use and misuse (confirmatory factor analysis Factor 22) 118,022 European ancestry individuals ? NR 2E-19 18.699 rs11940694 N/A alcohol use disorder measurement (EFO:0009458)
alcohol consumption measurement (EFO:0007878)
 PMID:38965376
GWAS819215_H GCST90013407 Liver enzyme levels (gamma-glutamyl transferase) 437,194 European ancestry individuals A 0.395382 3E-23 22.523 rs11940694 0.00538675 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:33972514
GWAS902234_H GCST90092929 Ratio of monounsaturated fatty acids to total fatty acids 115,006 European ancestry individuals A 0.394904 1E-8 8 rs11940694 0.0232844 fatty acid measurement (EFO:0005110)
 PMID:35213538
GWAS904186_H GCST90092928 Monounsaturated fatty acid levels 115,006 European ancestry individuals A 0.394904 2E-9 8.699 rs11940694 0.0252725 fatty acid measurement (EFO:0005110)
 PMID:35213538
None Available GCST90092948 Free cholesterol levels in small HDL 115,082 European ancestry individuals A 0.394896 1E-9 9 rs11940694 0.0254216 free cholesterol measurement (EFO:0008591)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS940399_H GCST90092952 Phospholipid levels in small HDL 115,082 European ancestry individuals A 0.394896 8E-10 9.097 rs11940694 0.025879 phospholipid measurement (EFO:0004639)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
None Available GCST90092950 Total lipid levels in small HDL 115,082 European ancestry individuals A 0.394896 8E-10 9.097 rs11940694 0.0260347 lipid measurement (EFO:0004529)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS974268_H GCST90132992 Alcohol consumption (drinks per month) (UKB data field 1578, 4424) 449,210 European ancestry individuals A 0.394614 7E-62 61.155 rs11940694 0.0357367 alcohol consumption measurement (EFO:0007878)
 PMID:32193382
GWAS984704_H GCST90018977 Serum uric acid levels 343,836 European ancestry individuals, 129,405 East Asian ancestry individuals G NR 4E-9 8.398 rs11940694 0.0106 uric acid measurement (EFO:0004761)
 PMID:34594039
GWAS990749_H GCST90319904 Serum urate levels 219,768 East Asian ancestry individuals, 677,373 European ancestry individuals, 132,182 individuals A NR 3E-10 9.523 rs11940694 0.0146 urate measurement (EFO:0004531)
 PMID:38658550
Database Acc Id Source(s)
GWAS Catalog GCST90243984 GWAS Catalog

RGD Curation Notes
Note Type Note Reference