GWAS568033_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS568033_H (bipolar disorder QTL GWAS568033 (human)) Homo sapiens

Symbol: GWAS568033_H
Name: bipolar disorder QTL GWAS568033 (human)
RGD ID: 406919057
Trait: bipolar disorder
LOD Score: Not Available
P Value: 8.0E-9
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381578,616,223 - 78,616,224RGD_MAPPER_PIPELINEGRCh38
GRCh371578,908,565 - 78,908,566RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS568033_HHumanbipolar disorder  IAGPrs28681284405850206 GWAS_CATALOGPMID:33479212
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
732613CHRNA3cholinergic receptor nicotinic alpha 3 subunit157859305278620996Human

Position Markers

Peak: (rs28681284)
Human AssemblyChrPosition (strand)Source
GRCh381578,616,223 - 78,616,224RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406919057GWAS568033_Hbipolar disorder QTL GWAS568033 (human)8e-09bipolar disorder157861622378616224Human
407066499GWAS715475_Hobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa QTL GWAS715475 (human)6e-12obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa157861622378616224Human
407152528GWAS801504_Hschizophrenia QTL GWAS801504 (human)3e-12schizophrenia157861622378616224Human
407218800GWAS867776_Hschizophrenia QTL GWAS867776 (human)1e-12schizophrenia157861622378616224Human
407162082GWAS811058_HFEV/FVC ratio, response to bronchodilator QTL GWAS811058 (human)0.000001FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)157861622378616224Human
406977881GWAS626857_Hbipolar disorder QTL GWAS626857 (human)3e-08bipolar disorder157861622378616224Human
407296639GWAS945615_Hschizophrenia QTL GWAS945615 (human)6e-13schizophrenia157861622378616224Human
407121999GWAS770975_Hcigarettes per day measurement QTL GWAS770975 (human)2e-58cigarettes per day measurement157861622378616224Human
406977338GWAS626314_Hforced expiratory volume, response to bronchodilator QTL GWAS626314 (human)0.0000002forced expiratory volume, response to bronchodilatorforced expiratory volume (CMO:0000254)157861622378616224Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS568033_H GCST012091 Bipolar disorder (MTAG) at least 20,352 European ancestry cases, at least 31,358 European ancestry controls T 0.2207 8E-9 8.097 rs28681284 0.07864479 PMID:33479212
GWAS626314_H GCST003262 Post bronchodilator FEV1 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals T 0.185 2E-7 6.699 rs28681284 0.061 forced expiratory volume (EFO:0004314)
response to bronchodilator (GO:0097366)
 PMID:26634245
GWAS626857_H GCST010641 Bipolar disorder (MTAG) 65,682 individuals ? NR 3E-8 7.523 rs28681284 N/A PMID:32606422
GWAS770975_H GCST007459 Smoking behaviour (cigarettes smoked per day) up to 377,334 European ancestry individuals T 0.21 2E-58 57.699 rs28681284 0.048676305 cigarettes per day measurement (EFO:0006525)
 PMID:30643251
GWAS801504_H GCST009337 Schizophrenia 22,778 East Asian ancestry cases, 35,362 East Asian ancestry controls, 33,640 European ancestry cases, 43,456 European ancestry controls ? NR 3E-12 11.523 rs28681284 1.0848105 PMID:31740837
GWAS811058_H GCST003264 Post bronchodilator FEV1/FVC ratio 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals T 0.184 0.000001 6 rs28681284 0.011 FEV/FVC ratio (EFO:0004713)
response to bronchodilator (GO:0097366)
 PMID:26634245
GWAS867776_H GCST012089 Schizophrenia (MTAG) at least 33,640 European ancestry cases, at least 43,456 European ancestry controls T 0.2207 1E-12 12 rs28681284 0.09633881 PMID:33479212
GWAS945615_H GCST007201 Schizophrenia 14,023 East Asian ancestry cases, 33,640 European ancestry cases, 31,505 East Asian ancestry controls, 43,456 European ancestry controls C NR 6E-13 12.222 rs28681284 1.107 PMID:30285260
None Available GCST009600 Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) 19,009 European ancestry ADHD cases, 3,495 European ancestry anorexia cases, 18,381 European ancestry autism cases, 20,352 European ancestry bipolar disorder cases, 130,664 European ancestry major depression cases, 2,688 European ancestry OCD cases, 33,640 European ancestry schizophrenia cases, 4,645 European ancestry Tourette's cases, 494,162 European ancestry controls ? NR 6E-12 11.222 rs28681284 N/A obsessive-compulsive disorder (EFO:0004242)
attention deficit hyperactivity disorder (EFO:0003888)
Tourette syndrome (EFO:0004895)
autism spectrum disorder (EFO:0003756)
 PMID:31835028
Database Acc Id Source(s)
GWAS Catalog GCST012091 GWAS Catalog

RGD Curation Notes
Note Type Note Reference