Zfp878 (zinc finger protein 878) - Rat Genome Database

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Gene: Zfp878 (zinc finger protein 878) Rattus norvegicus
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Symbol: Zfp878
Name: zinc finger protein 878
RGD ID: 7600751
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Orthologous to human ZNF878 (zinc finger protein 878); INTERACTS WITH bisphenol A; benzo[a]pyrene (ortholog); dioxygen (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC130232.2; LOC102548917; zinc finger protein 490; zinc finger protein 709; zinc finger protein 844-like
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,890,878 - 17,920,716 (-)NCBIGRCr8
mRatBN7.21617,856,860 - 17,887,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,856,878 - 17,868,403 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01619,580,839 - 19,592,455 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,581,812 - 19,583,386 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01619,437,866 - 19,449,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1618,065,225 - 18,076,841 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp878Ratalpha-mannosidosis  ISORGD:32076338554872ClinVar Annotator: match by term: Deficiency of alpha-mannosidaseClinVarPMID:28492532
Zfp878RatCharcot-Marie-Tooth disease dominant intermediate B  ISORGD:32076338554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate BClinVarPMID:28492532
Zfp878Ratepisodic ataxia type 2  ISORGD:32076338554872ClinVar Annotator: match by term: Episodic ataxia type 2ClinVarPMID:28492532
Zfp878Ratglutaric acidemia I  ISORGD:32076338554872ClinVar Annotator: match by term: Glutaric aciduria, type 1ClinVarPMID:28492532


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp878Ratbenzo[a]pyrene increases methylationISORGD:32076336480464Benzo(a)pyrene results in increased methylation of ZNF878 exon; Benzo(a)pyrene results in increased methylation of ZNF878 more ...CTDPMID:27901495
Zfp878Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of ZNF878 mRNACTDPMID:25181051
Zfp878Ratdioxygen decreases expressionISORGD:32076336480464Oxygen deficiency results in decreased expression of ZNF878 mRNACTDPMID:26516004
Zfp878Ratmethylisothiazolinone increases expressionISORGD:320763364804642-methyl-4-isothiazolin-3-one results in increased expression of ZNF878 mRNACTDPMID:31629900
Zfp878RatO-methyleugenol increases expressionISORGD:32076336480464methyleugenol results in increased expression of ZNF878 mRNACTDPMID:32234424
Zfp878Ratokadaic acid increases expressionISORGD:32076336480464Okadaic Acid results in increased expression of ZNF878 mRNACTDPMID:38832940
Zfp878Raturethane increases expressionISORGD:32076336480464Urethane results in increased expression of ZNF878 mRNACTDPMID:28818685


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp878Ratregulation of DNA-templated transcription involved_inIEAInterPro:IPR001909|InterPro:IPR0360511600115GO_REF:0000002InterProGO_REF:0000002
Zfp878Ratregulation of gene expression involved_inIBAFB:FBgn0035625|MGI:1920093|MGI:1930121|MGI:2384854|MGI:2448528|MGI:2684938|MGI:2685844|MGI:3588194|MGI:99655|PANTHER:PTN001818762|RGD:619929|UniProtKB:O75626|UniProtKB:Q13029|UniProtKB:Q9NQV5|UniProtKB:Q9NQX0|UniProtKB:Q9NQX1|UniProtKB:Q9Y462|WB:WBGene00003847|ZFIN:ZDB-GENE-030131-2193|ZFIN:ZDB-GENE-030131-2709|ZFIN:ZDB-GENE-040708-1|ZFIN:ZDB-GENE-041114-1721600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp878Ratnucleus is_active_inIBAFB:FBgn0035625|MGI:1920093|MGI:1930121|MGI:2384854|MGI:2448528|MGI:2684938|MGI:3588194|MGI:99655|PANTHER:PTN001818762|UniProtKB:O75626|UniProtKB:P17026|UniProtKB:Q13029|UniProtKB:Q9GZV8|UniProtKB:Q9H4Q4|UniProtKB:Q9NQV5|UniProtKB:Q9NQX1|UniProtKB:Q9Y462|WB:WBGene00003847|ZFIN:ZDB-GENE-030131-27091600115GO_REF:0000033GO_CentralGO_REF:0000033
Zfp878Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Zfp878Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp878Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Zfp878Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Zfp878
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,890,878 - 17,920,716 (-)NCBIGRCr8
mRatBN7.21617,856,860 - 17,887,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,856,878 - 17,868,403 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01619,580,839 - 19,592,455 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,581,812 - 19,583,386 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01619,437,866 - 19,449,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1618,065,225 - 18,076,841 (-)NCBICelera
Cytogenetic Map16p14NCBI
ZNF878
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,043,602 - 12,052,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,043,805 - 12,052,961 (-)EnsemblGRCh38hg38GRCh38
GRCh371912,154,620 - 12,163,776 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,015,620 - 12,028,127 (-)NCBINCBI36Build 36hg18NCBI36
Celera1912,048,979 - 12,061,496 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,728,993 - 11,738,093 (-)NCBIHuRef
CHM1_11912,154,431 - 12,163,590 (-)NCBICHM1_1
T2T-CHM13v2.01912,171,809 - 12,181,178 (-)NCBIT2T-CHM13v2.0

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Variants in Zfp878
164 total Variants

1 to 10 of 28 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat

1 to 10 of 28 rows






Ensembl Acc Id: ENSRNOT00000090131   ⟹   ENSRNOP00000075688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,856,878 - 17,868,403 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112727   ⟹   ENSRNOP00000084864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,856,878 - 17,862,464 (-)Ensembl
RefSeq Acc Id: NM_001409026   ⟹   NP_001395955
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,890,884 - 17,902,501 (-)NCBI
mRatBN7.21617,856,878 - 17,868,497 (-)NCBI
RefSeq Acc Id: XM_039095184   ⟹   XP_038951112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,890,878 - 17,920,716 (-)NCBI
mRatBN7.21617,856,860 - 17,887,019 (-)NCBI
Protein RefSeqs NP_001395955 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951112 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90824 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075688.2
  ENSRNOP00000084864
  ENSRNOP00000084864.1
RefSeq Acc Id: XP_038951112   ⟸   XM_039095184
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000075688   ⟸   ENSRNOT00000090131
Ensembl Acc Id: ENSRNOP00000084864   ⟸   ENSRNOT00000112727
RefSeq Acc Id: NP_001395955   ⟸   NM_001409026
- UniProtKB: A0A0G2KB80 (UniProtKB/TrEMBL),   A6K9R3 (UniProtKB/TrEMBL)
C2H2-type   KRAB

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KB80-F1-model_v2 AlphaFold A0A0G2KB80 1-495 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11862 BioCyc
Ensembl Genes ENSRNOG00000060701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090131.2 UniProtKB/TrEMBL
  ENSRNOT00000112727 ENTREZGENE
  ENSRNOT00000112727.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel_C2H2_ZnFinger UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene LOC102548917 ENTREZGENE
PANTHER IP01015P-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 544-RELATED UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp878 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060701 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2KB80 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GB55_RAT UniProtKB/TrEMBL
  A6K9R3 ENTREZGENE, UniProtKB/TrEMBL
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Zfp878  zinc finger protein 878  LOC102548917  zinc finger protein 844-like  Symbol and Name Changed 1299863 APPROVED
2022-06-02 LOC102548917  zinc finger protein 844-like  AC130232.2    Data merged from RGD:15013522 737654 PROVISIONAL
2019-11-08 AC130232.2        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-12-18 LOC102548917  zinc finger protein 844-like      Symbol and Name status set to provisional 70820 PROVISIONAL