Tep1 (telomerase associated protein 1) - Rat Genome Database

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Gene: Tep1 (telomerase associated protein 1) Rattus norvegicus
Analyze
Symbol: Tep1
Name: telomerase associated protein 1
RGD ID: 3869
Description: Contributes to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Part of telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and stomach cancer. Orthologous to human TEP1 (telomerase associated protein 1); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: p230; p240; p80 telomerase homolog; rTLP1; telomerase protein 1; Telomerase protein component 1; telomerase-associated protein 1; Tlp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,519,429 - 26,567,073 (-)NCBIGRCr8
mRatBN7.21524,045,876 - 24,093,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,045,878 - 24,093,526 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,817,070 - 26,864,716 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,775,795 - 27,823,421 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,025,608 - 26,073,256 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,751,186 - 27,798,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,751,180 - 27,798,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,583,611 - 31,631,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,802,624 - 26,852,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,818,325 - 26,868,008 (-)NCBI
Celera1524,365,367 - 24,413,481 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tep1Rathepatocellular carcinoma susceptibilityISOTEP1 (Homo sapiens)152977750DNA:SNP:intron:rs1760893(human)RGD 
Tep1Rathepatocellular carcinoma disease_progressionISOTEP1 (Homo sapiens)152975963associated with hepatitis B more ...RGD 
Tep1Ratintrahepatic cholangiocarcinoma  ISOTEP1 (Homo sapiens)152977753mRNA:increased expression:hepatocyte and biliary epithelium.RGD 
Tep1Ratstomach cancer susceptibilityISOTEP1 (Homo sapiens)152977750DNA:SNPs:introns:rs1713423 and rs1760893(human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tep1RatLung Neoplasms  ISOTEP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11323394

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tep1Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of TEP1 proteinCTDPMID:17337753
Tep1Rat1,2-dimethylhydrazine decreases expressionISOTep1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TEP1 mRNACTDPMID:22206623
Tep1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTEP1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of TEP1 mRNACTDPMID:17101203
Tep1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TEP1 mRNACTDPMID:32109520
Tep1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTep1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TEP1 mRNACTDPMID:24680724
Tep1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTEP1 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of TEP1 mRNACTDPMID:22574217
Tep1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of TEP1 mRNACTDPMID:21346803
Tep1Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of TEP1 proteinCTDPMID:34915118
Tep1Rat4,4'-sulfonyldiphenol increases expressionISOTep1 (Mus musculus)6480464bisphenol S results in increased expression of TEP1 mRNACTDPMID:30951980
Tep1Rat4-hydroxyphenyl retinamide decreases expressionISOTep1 (Mus musculus)6480464Fenretinide results in decreased expression of TEP1 mRNACTDPMID:28973697
Tep1Ratacrolein multiple interactionsISOTEP1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of TEP1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of TEP1 mRNACTDPMID:32699268
Tep1Rataflatoxin B1 increases expressionISOTep1 (Mus musculus)6480464Aflatoxin B1 results in increased expression of TEP1 mRNACTDPMID:19770486
Tep1Rataflatoxin B1 decreases methylationISOTEP1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of TEP1 intronCTDPMID:30157460
Tep1Rataflatoxin B1 increases expressionISOTEP1 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of TEP1 mRNACTDPMID:21641981 and PMID:22100608
Tep1Ratalpha-pinene multiple interactionsISOTEP1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of TEP1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of TEP1 mRNACTDPMID:32699268
Tep1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of TEP1 mRNACTDPMID:16483693
Tep1Ratantirheumatic drug decreases expressionISOTEP1 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of TEP1 mRNACTDPMID:24449571
Tep1Rataristolochic acid A increases expressionISOTEP1 (Homo sapiens)6480464aristolochic acid I results in increased expression of TEP1 mRNACTDPMID:33212167
Tep1Ratarsenite(3-) multiple interactionsISOTEP1 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to TEP1 mRNA]CTDPMID:32406909
Tep1Ratbenzamide decreases expressionISOTEP1 (Homo sapiens)6480464benzamide results in decreased expression of TEP1 mRNA and benzamide results in decreased expression of TEP1 proteinCTDPMID:16098204

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Tep1RatRNA-templated DNA biosynthetic process involved_inIEAGO:00037201600115GO_REF:0000108GOCGO_REF:0000108
Tep1RatRNA-templated DNA biosynthetic process involved_inICGO:00037201299082PMID:9118230BHF-UCL 
Tep1Rattelomere maintenance via recombination involved_inIEAUniProtKB:Q99973 and ensembl:ENSP000002627151600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Rattelomere maintenance via recombination involved_inIBAPANTHER:PTN002894131 and UniProtKB:Q999731600115GO_REF:0000033GO_CentralGO_REF:0000033
Tep1Rattelomere maintenance via recombination involved_inISOTEP1 (Homo sapiens)1624291 PMID:10810353RGDPMID:10810353
Tep1Rattelomere maintenance via telomerase NOT|acts_upstream_of_or_withinISOTep1 (Mus musculus)1624291MGI:2685589 PMID:15169895RGDPMID:15169895

Cellular Component
1 to 17 of 17 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tep1Ratchromosome located_inIEAUniProtKB-KW:KW-01581600115GO_REF:0000043UniProtGO_REF:0000043
Tep1Ratchromosome, telomeric region located_inIEAUniProtKB-SubCell:SL-02761600115GO_REF:0000044UniProtGO_REF:0000044
Tep1Ratchromosome, telomeric region located_inIEAUniProtKB-KW:KW-07791600115GO_REF:0000043UniProtGO_REF:0000043
Tep1Ratcytoplasm located_inISOTEP1 (Homo sapiens)1624291 PMID:7876352RGDPMID:7876352
Tep1Ratcytoplasm located_inIEAUniProtKB:Q99973 and ensembl:ENSP000002627151600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Ratnuclear matrix located_inIEAUniProtKB:Q99973 and ensembl:ENSP000002627151600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Ratnuclear matrix located_inISOTEP1 (Homo sapiens)1624291 PMID:7876352RGDPMID:7876352
Tep1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Tep1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Tep1Ratribonucleoprotein complex part_ofIEAUniProtKB-KW:KW-06871600115GO_REF:0000043UniProtGO_REF:0000043
Tep1Ratribonucleoprotein complex  IDA 1300486 RGD 
Tep1Rattelomerase holoenzyme complex part_ofISOTEP1 (Homo sapiens)1624291 PMID:12135483RGDPMID:12135483
Tep1Rattelomerase holoenzyme complex part_ofIBAMGI:109573 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tep1Rattelomerase holoenzyme complex part_ofISOTep1 (Mus musculus)1624291 PMID:9020079RGDPMID:9020079
Tep1Rattelomerase holoenzyme complex part_ofIEAUniProtKB:P97499 and ensembl:ENSMUSP000000064441600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Rattelomerase holoenzyme complex part_ofIDA 1299082PMID:9118230BHF-UCL 
Tep1Rattelomerase holoenzyme complex part_ofIEAUniProtKB:Q99973 and ensembl:ENSP000002627151600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
1 to 20 of 20 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tep1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Tep1Ratenzyme binding enablesIEAUniProtKB:Q99973 and ensembl:ENSP000002627151600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Ratenzyme binding enablesISOTEP1 (Homo sapiens)1624291UniProtKB:Q9UKK3 and PMID:15169895RGDPMID:15169895
Tep1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Tep1Ratp53 binding enablesIEAUniProtKB:Q99973 and ensembl:ENSP000002627151600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Ratp53 binding enablesISOTEP1 (Homo sapiens)1624291UniProtKB:P04637 and PMID:10597287RGDPMID:10597287
Tep1Ratprotein binding enablesISOTEP1 (Homo sapiens)1624291UniProtKB:Q5T6F2 more ...RGDPMID:32296183
Tep1RatRNA binding enablesIEAInterPro:IPR0088581600115GO_REF:0000002InterProGO_REF:0000002
Tep1RatRNA binding enablesIEAUniProtKB:P97499 and ensembl:ENSMUSP000000064441600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1RatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
Tep1RatRNA binding enablesISOTep1 (Mus musculus)1624291 PMID:11027287RGDPMID:11027287
Tep1Rattelomerase activity contributes_toISOTEP1 (Homo sapiens)1624291 PMID:12135483RGDPMID:12135483
Tep1Rattelomerase activity contributes_toIEAUniProtKB:Q99973 and ensembl:ENSP000002627151600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Rattelomerase activity contributes_toIEAUniProtKB:P97499 and ensembl:ENSMUSP000000064441600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Rattelomerase activity contributes_toIBAMGI:109573 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tep1Rattelomerase activity contributes_toISOTep1 (Mus musculus)1624291 PMID:9020079RGDPMID:9020079
Tep1Rattelomerase activity contributes_toIDA 1299082PMID:9118230BHF-UCL 
Tep1Rattelomerase RNA binding enablesIEAUniProtKB:P97499 and ensembl:ENSMUSP000000064441600115GO_REF:0000107EnsemblGO_REF:0000107
Tep1Rattelomerase RNA binding enablesISOTep1 (Mus musculus)1624291 PMID:9020079RGDPMID:9020079
Tep1Rattelomerase RNA binding enablesIBAMGI:109573 and PANTHER:PTN0028941311600115GO_REF:0000033GO_CentralGO_REF:0000033
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Two genetic variants in telomerase-associated protein 1 are associated with stomach cancer risk. Jin DH, etal., J Hum Genet. 2016 Oct;61(10):885-889. doi: 10.1038/jhg.2016.71. Epub 2016 Jun 16.
4. Prognostic impact of telomere maintenance gene polymorphisms on hepatocellular carcinoma patients with chronic hepatitis B. Jung SW, etal., Hepatology. 2014 May;59(5):1912-20. doi: 10.1002/hep.26655. Epub 2014 Mar 27.
5. RNA location and modeling of a WD40 repeat domain within the vault. Kong LB, etal., RNA 2000 Jun;6(6):890-900.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Nakayama J, etal., Cell 1997 Mar 21;88(6):875-84.
8. In situ nucleic acid detection of human telomerase in intrahepatic cholangiocarcinoma and its preneoplastic lesion. Ozaki S, etal., Hepatology. 1999 Oct;30(4):914-9. doi: 10.1002/hep.510300419.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:1300486   PMID:7876352   PMID:9020079   PMID:10551828   PMID:10597287   PMID:10810353   PMID:11027287   PMID:12135483   PMID:15169895  



Tep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,519,429 - 26,567,073 (-)NCBIGRCr8
mRatBN7.21524,045,876 - 24,093,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,045,878 - 24,093,526 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,817,070 - 26,864,716 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,775,795 - 27,823,421 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,025,608 - 26,073,256 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,751,186 - 27,798,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,751,180 - 27,798,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,583,611 - 31,631,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,802,624 - 26,852,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,818,325 - 26,868,008 (-)NCBI
Celera1524,365,367 - 24,413,481 (-)NCBICelera
Cytogenetic Map15p14NCBI
TEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,365,667 - 20,413,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,365,667 - 20,413,501 (-)EnsemblGRCh38hg38GRCh38
GRCh371420,833,826 - 20,881,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,905,766 - 19,951,420 (-)NCBINCBI36Build 36hg18NCBI36
Build 341419,905,765 - 19,951,420NCBI
Celera14694,983 - 742,708 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14955,689 - 1,003,240 (-)NCBIHuRef
CHM1_11420,835,235 - 20,882,954 (-)NCBICHM1_1
T2T-CHM13v2.01414,562,579 - 14,610,445 (-)NCBIT2T-CHM13v2.0
Tep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,061,513 - 51,108,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,061,516 - 51,108,017 (-)EnsemblGRCm39 Ensembl
GRCm381450,824,059 - 50,870,579 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,824,059 - 50,870,560 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,443,736 - 51,490,229 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,745,764 - 49,792,493 (-)NCBIMGSCv36mm8
Celera1447,114,946 - 47,163,125 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.26NCBI
Tep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,162,186 - 1,215,723 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,162,067 - 1,215,746 (-)NCBIChiLan1.0ChiLan1.0
TEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21521,872,708 - 21,920,785 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,089,195 - 21,137,274 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,240,370 - 1,285,787 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,293,326 - 19,338,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,293,452 - 19,332,960 (-)Ensemblpanpan1.1panPan2
TEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,716,887 - 17,748,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,716,887 - 17,764,356 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,201,865 - 18,237,404 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01517,975,936 - 18,011,501 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1517,975,936 - 18,007,251 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,658,710 - 17,694,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,713,441 - 17,749,086 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,842,350 - 17,878,168 (-)NCBIUU_Cfam_GSD_1.0
Tep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,593,954 - 77,632,838 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936877575,037 - 641,642 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936877575,264 - 613,965 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,491,053 - 78,530,183 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,488,248 - 78,530,185 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,511,111 - 83,558,528 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TEP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12920,880,255 - 20,928,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2920,883,678 - 20,923,313 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,493,523 - 25,552,352 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,774,662 - 4,812,769 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,770,678 - 4,812,879 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tep1
129 total Variants

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:18
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000012235
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat

1 to 10 of 25 rows
TEP1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,066,590 - 24,066,782 (+)MAPPERmRatBN7.2
Rnor_6.01527,771,900 - 27,772,091NCBIRnor6.0
Rnor_5.01531,604,325 - 31,604,516UniSTSRnor5.0
RGSC_v3.41526,824,799 - 26,824,990UniSTSRGSC3.4
Celera1524,386,410 - 24,386,601UniSTS
Cytogenetic Map15p14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000079506   ⟹   ENSRNOP00000073225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,045,878 - 24,093,526 (-)Ensembl
Rnor_6.0 Ensembl1527,751,188 - 27,798,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088981   ⟹   ENSRNOP00000068552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,045,878 - 24,091,950 (-)Ensembl
Rnor_6.0 Ensembl1527,751,180 - 27,798,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100610   ⟹   ENSRNOP00000078028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,045,878 - 24,093,482 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105915   ⟹   ENSRNOP00000077288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,045,878 - 24,093,526 (-)Ensembl
RefSeq Acc Id: NM_022591   ⟹   NP_072113
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,519,429 - 26,567,073 (-)NCBI
mRatBN7.21524,045,876 - 24,093,526 (-)NCBI
Rnor_6.01527,751,186 - 27,798,839 (-)NCBI
Rnor_5.01531,583,611 - 31,631,251 (-)NCBI
RGSC_v3.41526,802,624 - 26,852,308 (-)RGD
Celera1524,365,367 - 24,413,481 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093640   ⟹   XP_038949568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,519,429 - 26,544,977 (-)NCBI
mRatBN7.21524,045,876 - 24,071,427 (-)NCBI
RefSeq Acc Id: XM_039093641   ⟹   XP_038949569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,539,541 - 26,567,062 (-)NCBI
mRatBN7.21524,065,987 - 24,093,510 (-)NCBI
RefSeq Acc Id: XM_039093642   ⟹   XP_038949570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,519,429 - 26,540,162 (-)NCBI
mRatBN7.21524,045,876 - 24,066,610 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_072113 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949568 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949569 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949570 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB51690 (Get FASTA)   NCBI Sequence Viewer  
  EDL88417 (Get FASTA)   NCBI Sequence Viewer  
  EDL88418 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073225
GenBank Protein O08653 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_072113   ⟸   NM_022591
- UniProtKB: O08653 (UniProtKB/Swiss-Prot),   A6KEB2 (UniProtKB/TrEMBL),   F1LPX8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073225   ⟸   ENSRNOT00000079506
Ensembl Acc Id: ENSRNOP00000068552   ⟸   ENSRNOT00000088981
RefSeq Acc Id: XP_038949568   ⟸   XM_039093640
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949570   ⟸   XM_039093642
- Peptide Label: isoform X3
NACHT   TROVE

Name Modeler Protein Id AA Range Protein Structure
AF-O08653-F1-model_v2 AlphaFold O08653 1-2629 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699623
Promoter ID:EPDNEW_R10145
Type:initiation region
Name:Tep1_1
Description:telomerase associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01527,798,776 - 27,798,836EPDNEW


1 to 40 of 46 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-14056 BioCyc
Ensembl Genes ENSRNOG00000051706 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000079506 ENTREZGENE
Gene3D-CATH 1.25.40.370 UniProtKB/Swiss-Prot
  2.130.10.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro DUF4062 UniProtKB/Swiss-Prot
  DUF5920 UniProtKB/Swiss-Prot
  NACHT_NTPase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Telomerase_Complex_Comp UniProtKB/Swiss-Prot
  TEP1_N UniProtKB/Swiss-Prot
  TROVE_dom UniProtKB/Swiss-Prot
  TROVE_dom_sf UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:64523 UniProtKB/Swiss-Prot
NCBI Gene Tep1 ENTREZGENE
PANTHER TELOMERASE PROTEIN COMPONENT 1 UniProtKB/Swiss-Prot
  TELOMERASE PROTEIN COMPONENT 1 TEP1 UniProtKB/Swiss-Prot
Pfam DUF4062 UniProtKB/Swiss-Prot
  DUF5920 UniProtKB/Swiss-Prot
  NACHT UniProtKB/Swiss-Prot
  TEP1_N UniProtKB/Swiss-Prot
  TROVE UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot
PhenoGen Tep1 PhenoGen
PROSITE NACHT UniProtKB/Swiss-Prot
  TEP1_N UniProtKB/Swiss-Prot
  TROVE UniProtKB/Swiss-Prot
  WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051706 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF140864 UniProtKB/Swiss-Prot
  SSF50978 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2JT33_RAT UniProtKB/TrEMBL
1 to 40 of 46 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Tep1  telomerase associated protein 1  Tlp1  Telomerase protein component 1  Symbol and Name updated 629477 APPROVED
2002-06-10 Tlp1  Telomerase protein component 1      Symbol and Name status set to approved 70586 APPROVED