Spaca5 (sperm acrosome associated 5) - Rat Genome Database

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Gene: Spaca5 (sperm acrosome associated 5) Rattus norvegicus
Analyze
Symbol: Spaca5
Name: sperm acrosome associated 5
RGD ID: 1584964
Description: Predicted to enable lysozyme activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be active in acrosomal vesicle and sperm flagellum. Orthologous to several human genes including SPACA5 (sperm acrosome associated 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314431; similar to PNPK6288; sperm acrosome-associated protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,472,369 - 3,475,552 (-)NCBIGRCr8
mRatBN7.2X918,817 - 922,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX918,817 - 922,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX946,948 - 950,132 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,422,640 - 4,425,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X743,174 - 746,359 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X912,770 - 915,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX912,770 - 915,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X907,618 - 910,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX1,488,462 - 1,491,645 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spaca5Ratautistic disorder  ISOSPACA5 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Spaca5Ratcongenital disorder of glycosylation type IIm  ISOSPACA5 (Homo sapiens)8554872ClinVar Annotator: match by term: DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 22ClinVarPMID:28492532
Spaca5Ratimmune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  ISOSPACA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Insulin-dependent diabetes mellitus secretory diarrhea syndromeClinVarPMID:11137992 more ...
Spaca5Ratneurodegeneration with brain iron accumulation 5  ISOSPACA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Beta-propeller protein-associated neurodegenerationClinVarPMID:28492532
Spaca5Ratsyndromic X-linked intellectual disability Lubs type  ISOSPACA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
Spaca5RatX-linked epilepsy with variable learning disabilities and behavior disorders  ISOSPACA5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:28492532
Spaca5RatX-linked severe congenital neutropenia  ISOSPACA5 (Homo sapiens)8554872ClinVar Annotator: match by term: X-linked severe congenital neutropeniaClinVarPMID:10698340 more ...

1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spaca5Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISOSpaca5 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spaca5Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOSpaca5 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spaca5Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOSpaca5 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spaca5Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SPACA5 mRNACTDPMID:33387578
Spaca5Rat2,4,4'-trichlorobiphenyl multiple interactionsISOSpaca5 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spaca5Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of SPACA5 mRNACTDPMID:28959563
Spaca5Rataflatoxin B1 decreases methylationISOSPACA5 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of SPACA5 geneCTDPMID:27153756
Spaca5Ratbenzo[a]pyrene affects methylationISOSPACA5 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of SPACA5 promoterCTDPMID:27901495
Spaca5Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of SPACA5 mRNACTDPMID:25181051
Spaca5Ratdiquat decreases expressionISOSpaca5 (Mus musculus)6480464Diquat results in decreased expression of SPACA5 proteinCTDPMID:36851058
Spaca5Ratgenistein increases expressionISOSpaca5 (Mus musculus)6480464Genistein results in increased expression of SPACA5 mRNACTDPMID:32186404
Spaca5Ratgentamycin decreases expressionEXP 6480464Gentamicins results in decreased expression of SPACA5 mRNACTDPMID:33387578
Spaca5Ratmono(2-ethylhexyl) phthalate decreases expressionISOSPACA5 (Homo sapiens)6480464mono-(2-ethylhexyl)phthalate results in decreased expression of SPACA5 mRNACTDPMID:36314267
Spaca5RatMonobutylphthalate decreases expressionEXP 6480464monobutyl phthalate results in decreased expression of SPACA5 mRNACTDPMID:29162477
Spaca5Ratparacetamol decreases expressionEXP 6480464Acetaminophen results in decreased expression of SPACA5 mRNACTDPMID:33387578
Spaca5RatPCB138 multiple interactionsISOSpaca5 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spaca5Ratpermethrin increases expressionISOSPACA5 (Homo sapiens)6480464Permethrin results in increased expression of SPACA5 mRNACTDPMID:37047231
Spaca5Ratsodium fluoride increases expressionISOSpaca5 (Mus musculus)6480464Sodium Fluoride results in increased expression of SPACA5 proteinCTDPMID:28918527
Spaca5Rattrichloroethene decreases expressionEXP 6480464Trichloroethylene results in decreased expression of SPACA5 mRNACTDPMID:33387578

1 to 19 of 19 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spaca5Ratfusion of sperm to egg plasma membrane involved in single fertilization involved_inIBAMGI:1922872 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spaca5Ratacrosomal vesicle is_active_inIBAMGI:1916282 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spaca5Ratsperm flagellum is_active_inIBAMGI:1916282 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spaca5Ratlysozyme activity enablesIBAFB:FBgn0004427 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spaca5Ratlysozyme activity enablesIEAInterPro:IPR0009741600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Spaca5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,472,369 - 3,475,552 (-)NCBIGRCr8
mRatBN7.2X918,817 - 922,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX918,817 - 922,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX946,948 - 950,132 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,422,640 - 4,425,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X743,174 - 746,359 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X912,770 - 915,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX912,770 - 915,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X907,618 - 910,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX1,488,462 - 1,491,645 (-)NCBICelera
Cytogenetic MapXq11NCBI
SPACA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,004,336 - 48,009,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,004,336 - 48,009,733 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,863,734 - 47,869,130 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,748,678 - 47,754,074 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX52,182,559 - 52,187,955 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX45,698,884 - 45,704,280 (+)NCBIHuRef
CHM1_1X47,894,879 - 47,900,324 (+)NCBICHM1_1
T2T-CHM13v2.0X47,414,513 - 47,419,909 (+)NCBIT2T-CHM13v2.0
Spaca5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,934,669 - 20,944,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,934,645 - 20,944,202 (+)EnsemblGRCm39 Ensembl
GRCm38X21,068,430 - 21,077,958 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX21,068,406 - 21,077,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,645,532 - 20,655,089 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,225,447 - 20,234,847 (+)NCBIMGSCv36mm8
CeleraX19,202,482 - 19,211,886 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.59NCBI
Spaca5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955516103,674 - 106,082 (-)NCBIChiLan1.0ChiLan1.0
SPACA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,628,747 - 49,631,850 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,632,342 - 49,635,222 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,435,554 - 40,441,190 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,328,726 - 48,334,106 (+)NCBIpanpan1.1PanPan1.1panPan2
SPACA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,590,329 - 41,612,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,353,440 - 41,593,082 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,968,120 - 15,989,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,727,776 - 41,749,559 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,727,802 - 41,731,591 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,715,021 - 41,736,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,703,102 - 41,724,897 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,796,676 - 41,818,457 (+)NCBIUU_Cfam_GSD_1.0
SPACA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,476,587 - 42,478,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,476,719 - 42,478,783 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,046,163 - 47,048,227 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231905
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,170,226 - 45,175,615 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607610,436,318 - 10,441,371 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Spaca5
7 total Variants

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:7
Interacting mature miRNAs:7
Transcripts:ENSRNOT00000075264
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 16 41 49 48 17 23 17 6 104 59 21 11 33 31


RefSeq Transcripts NM_001108058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000075264   ⟹   ENSRNOP00000067235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX918,817 - 922,049 (-)Ensembl
Rnor_6.0 EnsemblX912,770 - 915,953 (-)Ensembl
RefSeq Acc Id: NM_001108058   ⟹   NP_001101528
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,472,369 - 3,475,552 (-)NCBI
mRatBN7.2X918,817 - 922,000 (-)NCBI
Rnor_6.0X912,770 - 915,953 (-)NCBI
Rnor_5.0X907,618 - 910,801 (-)NCBI
CeleraX1,488,462 - 1,491,645 (-)RGD
Sequence:
Protein RefSeqs NP_001101528 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97736 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067235.1
RefSeq Acc Id: NP_001101528   ⟸   NM_001108058
- Peptide Label: precursor
- UniProtKB: M0RCC1 (UniProtKB/TrEMBL),   A6JZP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067235   ⟸   ENSRNOT00000075264

Name Modeler Protein Id AA Range Protein Structure
AF-M0RCC1-F1-model_v2 AlphaFold M0RCC1 1-160 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3207 BioCyc
Ensembl Genes ENSRNOG00000045622 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075264.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.530.10 UniProtKB/TrEMBL
InterPro Glyco_hydro_22 UniProtKB/TrEMBL
  Glyco_hydro_22_lys UniProtKB/TrEMBL
  Lysozyme-like_dom UniProtKB/TrEMBL
KEGG Report rno:314431 UniProtKB/TrEMBL
NCBI Gene 314431 ENTREZGENE
PANTHER PTHR11407 UniProtKB/TrEMBL
  PTHR11407:SF31 UniProtKB/TrEMBL
Pfam Lys UniProtKB/TrEMBL
PhenoGen Spaca5 PhenoGen
PRINTS LYSOZYME UniProtKB/TrEMBL
  LYZLACT UniProtKB/TrEMBL
PROSITE LACTALBUMIN_LYSOZYME_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045622 RatGTEx
SMART LYZ1 UniProtKB/TrEMBL
Superfamily-SCOP SSF53955 UniProtKB/TrEMBL
UniProt A6JZP9 ENTREZGENE, UniProtKB/TrEMBL
  M0RCC1 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Spaca5  sperm acrosome associated 5  LOC314431  similar to PNPK6288  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC314431  similar to PNPK6288      Symbol and Name status set to provisional 70820 PROVISIONAL