Klrb1c (killer cell lectin like receptor B1C) - Rat Genome Database

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Gene: Klrb1c (killer cell lectin like receptor B1C) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Klrb1c
Name: killer cell lectin like receptor B1C
RGD ID: 1583336
Description: Predicted to enable signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Predicted to be active in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1); PARTICIPATES IN malaria pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1C; killer cell lectin-like receptor subfamily B member 1F; Klrb1f; LOC683758; natural killer cell surface protein NKR-P1F; NKR-P1B protein; NKR-P1F; similar to Nkrp1f protein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,068,249 - 164,080,724 (+)NCBIGRCr8
mRatBN7.24162,380,773 - 162,394,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,381,602 - 162,393,786 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4168,617,077 - 168,628,578 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,400,029 - 164,411,515 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,034,078 - 163,045,568 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04162,528,614 - 162,553,421 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4162,541,751 - 162,553,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04227,747,801 - 227,751,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,170,376 - 166,181,868 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4151,076,813 - 151,088,578 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klrb1cRatregulation of natural killer cell mediated cytotoxicity involved_inIBAMGI:107538 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klrb1cRatcell surface is_active_inIBAMGI:107538 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Klrb1cRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Klrb1cRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Klrb1cRatplasma membrane is_active_inIBAMGI:107538 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klrb1cRatcarbohydrate binding enablesIEAUniProtKB-KW:KW-04301600115GO_REF:0000043UniProtGO_REF:0000043
Klrb1cRatsignaling receptor activity enablesIBAMGI:107538 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klrb1cRatmalaria pathway  IEA 6907045 KEGGrno:05144

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:1506685   PMID:9133426   PMID:9390275   PMID:10229823   PMID:10229828   PMID:10704459   PMID:14607906   PMID:14609575   PMID:14707119   PMID:14764662   PMID:14990792   PMID:16455951  
PMID:16973387   PMID:17082577   PMID:17462921   PMID:19535641   PMID:19934022   PMID:20194751   PMID:20818394   PMID:21737317   PMID:23034280   PMID:25382546  



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Variants in Klrb1c
238 total Variants

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000010312
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat

1 to 10 of 35 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 27 37 70 69 38 25 38 6 159 73 17 31 48 31



Ensembl Acc Id: ENSRNOT00000010312   ⟹   ENSRNOP00000010312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4162,381,602 - 162,393,786 (+)Ensembl
Rnor_6.0 Ensembl4162,541,751 - 162,553,705 (+)Ensembl
RefSeq Acc Id: NM_001085403   ⟹   NP_001078872
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,068,249 - 164,080,724 (+)NCBI
mRatBN7.24162,382,199 - 162,394,688 (+)NCBI
Rnor_6.04162,541,939 - 162,552,930 (+)NCBI
Rnor_5.04227,747,801 - 227,751,934 (+)NCBI
Celera4151,076,813 - 151,088,578 (+)RGD
Sequence:
Protein RefSeqs NP_001078872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABO15819 (Get FASTA)   NCBI Sequence Viewer  
  ABO15825 (Get FASTA)   NCBI Sequence Viewer  
  CAA66111 (Get FASTA)   NCBI Sequence Viewer  
  EDM01761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010312.2
  ENSRNOP00000107942
GenBank Protein Q63378 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001078872   ⟸   NM_001085403
- UniProtKB: Q63378 (UniProtKB/Swiss-Prot),   A6IM28 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010312   ⟸   ENSRNOT00000010312
C-type lectin

Name Modeler Protein Id AA Range Protein Structure
AF-Q63378-F1-model_v2 AlphaFold Q63378 1-217 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42812 BioCyc
Ensembl Genes ENSRNOG00000007811 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010312.5 UniProtKB/Swiss-Prot
  ENSRNOT00000153277 ENTREZGENE
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLR_subfamily_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:683758 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 683758 ENTREZGENE
PANTHER KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klrb1c PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007811 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C-type lectin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IM28 ENTREZGENE, UniProtKB/TrEMBL
  KLRBF_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-28 Klrb1c  killer cell lectin like receptor B1C  Klrb1c  killer cell lectin-like receptor subfamily B member 1C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Klrb1c  killer cell lectin-like receptor subfamily B member 1C  LOC689809  similar to Nkrp1f protein  Data merged from RGD:1587571 1643240 APPROVED
2010-05-06 Klrb1c  killer cell lectin-like receptor subfamily B member 1C  Klrb1c  killer cell lectin-like receptor subfamily B member 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-24 Klrb1c  killer cell lectin-like receptor subfamily B member 1B  LOC683758  similar to Nkrp1f protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683758  similar to Nkrp1f protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689809  similar to Nkrp1f protein      Symbol and Name status set to provisional 70820 PROVISIONAL