Tdp2 (tyrosyl-DNA phosphodiesterase 2) - Rat Genome Database

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Gene: Tdp2 (tyrosyl-DNA phosphodiesterase 2) Chinchilla lanigera
Analyze
Symbol: Tdp2
Name: tyrosyl-DNA phosphodiesterase 2
RGD ID: 8875499
Description: ENCODES a protein that exhibits 5'-tyrosyl-DNA phosphodiesterase activity (ortholog); magnesium ion binding (ortholog); manganese ion binding (ortholog); INVOLVED IN double-strand break repair (ortholog); neuron development (ortholog); ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 23 (ortholog); cerebellar ataxia (ortholog); genetic disease (ortholog); FOUND IN aggresome (ortholog); cytoplasm (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,375,313 - 2,388,892 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554832,375,213 - 2,385,354 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
aggresome  (ISO)
cytoplasm  (ISO)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)
PML body  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tdp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,375,313 - 2,388,892 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554832,375,213 - 2,385,354 (+)NCBIChiLan1.0ChiLan1.0
TDP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,649,979 - 24,666,899 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,649,979 - 24,666,930 (-)EnsemblGRCh38hg38GRCh38
GRCh37624,650,207 - 24,667,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,758,184 - 24,775,094 (-)NCBINCBI36Build 36hg18NCBI36
Build 34624,758,184 - 24,775,094NCBI
Celera625,883,542 - 25,900,457 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,599,621 - 24,616,537 (-)NCBIHuRef
CHM1_1624,654,343 - 24,671,259 (-)NCBICHM1_1
T2T-CHM13v2.0624,520,363 - 24,537,292 (-)NCBIT2T-CHM13v2.0
Tdp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,015,642 - 25,026,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,015,662 - 25,026,136 (+)EnsemblGRCm39 Ensembl
GRCm381324,831,659 - 24,842,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,831,679 - 24,842,153 (+)EnsemblGRCm38mm10GRCm38
MGSCv371324,923,528 - 24,934,022 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361324,839,150 - 24,849,611 (+)NCBIMGSCv36mm8
Celera1325,062,324 - 25,072,818 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.7NCBI
Tdp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,656,969 - 40,668,362 (-)NCBIGRCr8
mRatBN7.21740,228,943 - 40,240,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,228,947 - 40,240,313 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1740,297,128 - 40,308,451 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,901,173 - 41,912,496 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,184,268 - 40,195,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,229,667 - 42,241,025 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,229,642 - 42,241,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01744,097,466 - 44,108,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,290,530 - 47,301,849 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1739,866,248 - 39,877,568 (-)NCBICelera
Cytogenetic Map17p11NCBI
TDP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2539,300,990 - 39,318,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1635,300,448 - 35,318,023 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,487,551 - 24,505,268 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,819,494 - 24,837,189 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,819,494 - 24,837,189 (-)Ensemblpanpan1.1panPan2
TDP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,693,203 - 22,707,054 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,693,110 - 22,707,008 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3522,660,843 - 22,674,624 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03522,815,655 - 22,829,433 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,814,198 - 22,829,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,621,127 - 22,634,899 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,668,709 - 22,682,476 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03524,105,036 - 24,118,785 (-)NCBIUU_Cfam_GSD_1.0
Tdp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024411772475 - 1,113 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004948563494 - 1,113 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TDP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,489,384 - 19,502,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,489,381 - 19,502,437 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,642,148 - 20,655,198 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TDP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,582,857 - 47,599,871 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,583,014 - 47,600,628 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604424,580,645 - 24,597,659 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tdp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,363,718 - 2,375,152 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247562,363,400 - 2,374,839 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000002938   ⟹   ENSCLAP00000002881
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554832,375,313 - 2,388,892 (+)Ensembl
RefSeq Acc Id: XM_005403367   ⟹   XP_005403424
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554832,375,213 - 2,385,354 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005403368   ⟹   XP_005403425
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554832,375,213 - 2,385,354 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005403424 (Get FASTA)   NCBI Sequence Viewer  
  XP_005403425 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000002881
  ENSCLAP00000002881.1
RefSeq Acc Id: XP_005403424   ⟸   XM_005403367
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UTE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005403425   ⟸   XM_005403368
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCLAP00000002881   ⟸   ENSCLAT00000002938

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002938 ENTREZGENE
  ENSCLAT00000002938.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
  TDP2-like UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
NCBI Gene Tdp2 ENTREZGENE
PANTHER TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN UniProtKB/TrEMBL
  TYROSYL-DNA PHOSPHODIESTERASE 2 UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/TrEMBL
  UBA_4 UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
  SSF56219 UniProtKB/TrEMBL
UniProt A0A8C2UTE1 ENTREZGENE, UniProtKB/TrEMBL