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Gene: Mars2 (methionyl-tRNA synthetase 2, mitochondrial) Chinchilla lanigera

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Symbol:

Mars2

Name:

methionyl-tRNA synthetase 2, mitochondrial

RGD ID:

8742531

Description:

ENCODES a protein that exhibits methionine-tRNA ligase activity (ortholog); INVOLVED IN methionyl-tRNA aminoacylation (ortholog); ASSOCIATED WITH combined oxidative phosphorylation deficiency 25 (ortholog); Neurodevelopmental Disorders (ortholog); spastic ataxia 3 (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

methionine--tRNA ligase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	2,968,574 - 2,970,387 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	2,967,541 - 2,970,443 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

combined oxidative phosphorylation deficiency 25 (ISO)

Neurodevelopmental Disorders (ISO)

spastic ataxia 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methionyl-tRNA aminoacylation (ISO)

Cellular Component

mitochondrial matrix (ISO)

mitochondrion (ISO)

Molecular Function

methionine-tRNA ligase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mars2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	2,968,574 - 2,970,387 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	2,967,541 - 2,970,443 (-)	NCBI	ChiLan1.0	ChiLan1.0

MARS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	197,705,369 - 197,708,395 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	197,705,369 - 197,708,395 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	198,570,093 - 198,573,119 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	198,278,332 - 198,281,359 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	198,395,592 - 198,398,619	NCBI
Celera	2	192,325,854 - 192,328,884 (+)	NCBI		Celera
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	190,422,213 - 190,425,302 (+)	NCBI		HuRef
CHM1_1	2	198,575,868 - 198,578,954 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	198,189,049 - 198,192,078 (+)	NCBI		T2T-CHM13v2.0

Mars2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	55,276,336 - 55,279,217 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	55,276,336 - 55,287,629 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	55,237,177 - 55,240,058 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	55,237,177 - 55,248,470 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	55,294,021 - 55,296,902 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	55,181,766 - 55,183,665 (+)	NCBI		MGSCv36	mm8
Celera	1	55,757,314 - 55,760,195 (+)	NCBI		Celera
Cytogenetic Map	1	C1.2	NCBI
cM Map	1	28.08	NCBI

Mars2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	64,214,935 - 64,228,408 (+)	NCBI		GRCr8
mRatBN7.2	9	56,720,408 - 56,729,991 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	56,720,983 - 56,723,820 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	61,823,441 - 61,826,357 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	64,434,904 - 64,436,664 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	9	61,823,531 - 61,825,291 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	64,238,264 - 64,241,170 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	54,026,948 - 54,029,796 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	54,142,376 - 54,156,301 (+)	NCBI
Celera	9	54,201,937 - 54,204,853 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

MARS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	100,319,841 - 100,339,924 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	100,340,545 - 100,354,917 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	84,954,833 - 84,957,871 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	202,847,382 - 202,850,459 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	202,847,478 - 202,849,259 (+)	Ensembl	panpan1.1		panPan2

MARS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	7,149,375 - 7,155,318 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	7,149,418 - 7,152,418 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	8,095,700 - 8,106,588 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	7,039,982 - 7,050,870 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	7,039,982 - 7,041,763 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	7,038,526 - 7,049,414 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	7,005,322 - 7,016,210 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	7,029,216 - 7,032,187 (+)	NCBI		UU_Cfam_GSD_1.0

Mars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	155,285,263 - 155,288,032 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936506	1,550,957 - 1,552,738 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936506	1,550,068 - 1,552,776 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MARS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	101,510,638 - 101,512,419 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	101,508,668 - 101,524,076 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MARS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	83,186,370 - 83,193,464 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	83,187,344 - 83,189,125 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	116,255,542 - 116,262,526 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mars2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624889	2,630,303 - 2,632,084 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624889	2,624,053 - 2,632,177 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013512032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01001742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01001743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01042364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01421758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000015228 ⟹ ENSCLAP00000015068

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955403	2,968,574 - 2,970,387 (-)	Ensembl

RefSeq Acc Id:

XM_013512032 ⟹ XP_013367486

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955403	2,967,541 - 2,970,443 (-)	NCBI

Sequence:

show sequence

CGCCGCCCCCACGTGCTTCCGGGACGCCGTGTGCCCCGCTGCGGCCGGCGCGCGCGATGCTGCG
AGCCTCAGTCCTTCGGGCTCTGGGGCGCCCGGCGGCCGCTAGGGTCCCTCTCCTGGGGGGCCCC
GGCGCGCGCCGCTACGGCTCTGGTGCCCCGACTGTCGGCGAGGACGCGGCCCACGCGCGCGCCT
ACTTCACCACGCCCGTCTTCTACGTGAACGCCGCGCCGCACATCGGGCACCTGTACTCGGCGCT
GCTGGCCGACGCCCTGTGCCGCCTCCGCGGCCTGCGGGCTCCCGGCGCCGCCGCCCCGCGCCTG
TCCACCGGCACGGACGAGCACGGCCTGAAGATCCAGCAGGCGGCGGCCGCCGCGGGCCTGGCCC
CGCGCGCGCTGTGCGACCGCGTCTCCGCGCAGTTCCGCCGGCTGTTCCGGGACGCGGGCGTCGC
CGCCACCGACTTCATCCGCACCACCGAGGCTCGGCACCGGGCGGCCGTGCAGCACTTCTGGGGC
GTCCTGGCGGCCCGCGGTCTGCTCTACAAGGGGCTCTACGAAGGCTGGTACTGCGCCTCCGATG
AGTGCTTTCTGCCGGACGCCAAGGTCACCCGGCAGCCGGGCCCCGCGGGGGAGTCGTGTCCCGT
GTCCCTGGAGAGCGGGCACCCCGTCTCCTGGACCAAGGAGGAAAACTACATTTTCAGGCTGTCC
CAGTTCCGGGAGCCGCTCCGGCGGTGGCTGCGAAGCAACCCGCGGGCGATCGTGCCCGAGCCGT
TCCATCACGCGGTCCTGCAGTGGCTGGAGGAGGAGCTGCCCGACCTCTCGGTGTCTCGCAGGAG
CAGCCACTTGCCCTGGGGCATCCCGGTCCCCGGGGACGACTCGCAGACGGTCTACGTGTGGGTG
GACGCGCTGGTCAACTACCTCACTGTCATTGGCTACCCGAACGCTGAGTTCAGGTCCTGGTGGC
CGGCCGCATCCCACATCATAGGTAAGGACATTCTCAAATTCCACGCCATCTATTGGCCCGCCCT
CCTCCTCGGGGCCGGACTGAGCCCTCCGCATCGCATCTACGTCCACTCGCACTGGACTGTGTGT
GGCCAAAAGATGTCCAAGAGCTTGGGCAACGTGGTGGATCCCATGGCCTGTCTCGATCGCTACA
CTGTGGACGGCTTCCGCTACTTTCTCCTTCGGCAGGGCGTTCCCAGCTGGGACTGTGACTACTA
CGACGAGAAGGTGGTTAAGCTGCTGGACTCCGAGCTGGCCGATGCCCTGGGAGGCCTTCTGAGC
CGGTGCACTGCCCGCAGAATCAATCCCGCTGGCACCTACCCAGCCTTCTGCCCCTCCTGCTTCC
CCAGGGAGCCGGGGGCGCAGGGGCCGGCGGTGCGCGCCCAGGCGGAGGACTATGCTCTTGTGAG
CGCCGTGGCTGCTCTGCCCAAGCAAGTAGCCGACTGCTATGAGAACTTCCAAATCTATAAGGCC
CTGGAGGCGGTGTCCAGCTGTGTCCGGCAGACTAACGGTTTCGTCCAAAGGCATGCCCCGTGGA
AACTGAGTTGGGAGAGCCCGGCGGATGCTCCCTGGCTGGGGACTGTGCTTCATGTGGCCTTGGA
ATGCTTACGAGTCTGTGGCACTTTGCTCCAGCCGGTTACCCCAAACCTAGCGGATAAGCTGCTG
TCCAGGCTGGGGGTCTCTGCCGCAGAGAGGGGCCTCGAAGAGCTCTCTTTCCTGCCTCGATTCT
ATGGACACCAGTGCCCTTTTGAAGGGAGGAGGCTGGGTCCCGAAACTGGGCTTTTGTTTCCAAG
ACTGGACCAGTCCAGGGCTCGGATGGTGAAAGCTCAGGGGACCTAGAGGCACAGTTCTTACTGG
TTTGTGGTAAAACTGCAAATGTTGTTTTTTCTTTTCAGGAACATTATACTAGTGTTTTCTAAAG
TGTTGCGTCAGATGAACACAAGCTGTTTCCCTGCGACAGAGCCTTCAGGTGCCTCCCCTCTTGG
TTTGCCCATTAACCACTGTCTTTGTCCACTACTACGTCTAACACTTCTGCAGGAGAGATGGGGA
AGAGACGGGTGCTGATACTATTCCTTTCATTGTACCGCTCTCCAGCCAGTTATTTGTGCAATCT
ACCTCTTAGGGTGTCTGCCTCTCAGGCTGATTAGTACAGTGACATCTTGGAGAGTAGGGGTTGG
AGGCCCCCACCCTTAGCTTTTACAGGTTACCCCTACTTTGTTGTATGTACTGGGTCTTCTGTAA
AAGCGGTTGTTTTATTAAACTTTAAAAACTAGTGCTCTAGACAAGATGAGCTTTGCTCACATTC
ACCCCTATACTTTATAGAGCCCTTCAGCCAGGACTCACTGGACCGACAGTCATGTCCTGAACAT
TACATGTCCACTAGTAGGGGGCTGTGGTCTCACACGTGTAATTCACATTGAGATTTCAGAATAT
TTAAAATAGTTTTCTGCTTTCTGATCTCAGATCTTTCACTTATTTTAAGGGATAACTGCAACCA
CTGTAGTTTTAACAGAAAGCAATAAAATAGAATTCTCAGTTTCTTAGAGACTACTGAAAAATGA
AACAAGTGTTTCACATGGTTTATACGATAAACTATAAAGCTTGAGGCACTTGGTATATTAAAAA
TTTCCAACTTTAATAACAGGTAACAGGTATGACTAATCTGTACAGACTTCAAGAGAGCAATATT
CTCTTTGTTCTTAGTCTTTTGTTATCCACATAATTTACCTCATGATTCCTTTTGGTTAATCGAG
ATCTGTAATACAATGTAGAAACTGTGTAATAGTTGCTGAAAATGGTAACACTTGAATTTCAAGT
AGTTTTCTGATTATTTGTTTTGCTCTTCTAACTTATTAAAGTTTAAACGTTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013367486	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000015068.1

RefSeq Acc Id:

XP_013367486 ⟸ XM_013512032

- UniProtKB:

A0A8C2VI74 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRASVLRALGRPAAARVPLLGGPGARRYGSGAPTVGEDAAHARAYFTTPVFYVNAAPHIGHLY
SALLADALCRLRGLRAPGAAAPRLSTGTDEHGLKIQQAAAAAGLAPRALCDRVSAQFRRLFRDA
GVAATDFIRTTEARHRAAVQHFWGVLAARGLLYKGLYEGWYCASDECFLPDAKVTRQPGPAGES
CPVSLESGHPVSWTKEENYIFRLSQFREPLRRWLRSNPRAIVPEPFHHAVLQWLEEELPDLSVS
RRSSHLPWGIPVPGDDSQTVYVWVDALVNYLTVIGYPNAEFRSWWPAASHIIGKDILKFHAIYW
PALLLGAGLSPPHRIYVHSHWTVCGQKMSKSLGNVVDPMACLDRYTVDGFRYFLLRQGVPSWDC
DYYDEKVVKLLDSELADALGGLLSRCTARRINPAGTYPAFCPSCFPREPGAQGPAVRAQAEDYA
LVSAVAALPKQVADCYENFQIYKALEAVSSCVRQTNGFVQRHAPWKLSWESPADAPWLGTVLHV
ALECLRVCGTLLQPVTPNLADKLLSRLGVSAAERGLEELSFLPRFYGHQCPFEGRRLGPETGLL
FPRLDQSRARMVKAQGT

hide sequence

Ensembl Acc Id:

ENSCLAP00000015068 ⟸ ENSCLAT00000015228

Protein Domains

Methionyl-tRNA synthetase anticodon-binding Methionyl/Leucyl tRNA synthetase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000010386	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000015228.1	UniProtKB/TrEMBL
Gene3D-CATH	2.170.220.10	UniProtKB/TrEMBL
	3.40.50.620	UniProtKB/TrEMBL
InterPro	Anticodon_Met	UniProtKB/TrEMBL
	Met-tRNA_synth_2	UniProtKB/TrEMBL
	Methionyl/Leucyl_tRNA_Synth	UniProtKB/TrEMBL
	MetRS_core	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
	tRNAsynth_Ia_anticodon-bd	UniProtKB/TrEMBL
NCBI Gene	Mars2	ENTREZGENE
PANTHER	METHIONINE--TRNA LIGASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR43326	UniProtKB/TrEMBL
Pfam	Anticodon_3	UniProtKB/TrEMBL
	tRNA-synt_1g	UniProtKB/TrEMBL
PRINTS	TRNASYNTHMET	UniProtKB/TrEMBL
Superfamily-SCOP	Nucleotidylyl transferase	UniProtKB/TrEMBL
	SSF47323	UniProtKB/TrEMBL
UniProt	A0A8C2VI74	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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