MIR6862-2 (microRNA 6862-2) - Rat Genome Database

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Gene: MIR6862-2 (microRNA 6862-2) Homo sapiens
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Symbol: MIR6862-2
Name: microRNA 6862-2
RGD ID: 8550976
HGNC Page HGNC:50192
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6862-2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,724,252 - 28,724,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,724,252 - 28,724,321 (+)EnsemblGRCh38hg38GRCh38
GRCh371628,735,573 - 28,735,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map16p11.2NCBI
CHM1_11629,414,437 - 29,414,506 (-)NCBICHM1_1
T2T-CHM13v2.01629,004,924 - 29,004,992 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR6862-2Humanchromosome 16p11.2 deletion syndrome, 220-kb  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Distal 16p11.2 microdeletion syndromeClinVar 
MIR6862-2Humanschizophrenia  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR6862-2Humansodium arsenite decreases expressionEXP 6480464sodium arsenite results in decreased expression of MIR6862-2 mRNACTDPMID:34032870

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR6862-2HumanSchizophrenia  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVar 
MIR6862-2HumanSchizophrenia  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
PMID:16381832   PMID:22955976   PMID:33414358  



.

1 to 10 of 323 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh37/hg19 13q11-34(chr13:19053605-115108528)x3 copy number gain See cases [RCV001353184] Chr13:19053605..115108528 [GRCh37]
Chr13:13q11-34		 pathogenic
NM_021954.4(GJA3):c.1137dup (p.Ser380fs) duplication Cataract 14 multiple types [RCV000018500] Chr13:20142151..20142152 [GRCh38]
Chr13:20716290..20716291 [GRCh37]
Chr13:13q12.11		 pathogenic
NM_021954.4(GJA3):c.723C>A (p.Asp241Glu) single nucleotide variant Cataract 14 multiple types [RCV000542799] Chr13:20142566 [GRCh38]
Chr13:20716705 [GRCh37]
Chr13:13q12.11		 uncertain significance
NC_000013.10:g.(?_20716100)_(20717447_?)dup duplication Cataract 14 multiple types [RCV000529409] Chr13:20141961..20143308 [GRCh38]
Chr13:20716100..20717447 [GRCh37]
Chr13:13q12.11		 uncertain significance
NM_021954.4(GJA3):c.188A>G (p.Asn63Ser) single nucleotide variant Cataract 14 multiple types [RCV000018499] Chr13:20143101 [GRCh38]
Chr13:20717240 [GRCh37]
Chr13:13q12.11		 pathogenic|likely pathogenic
NM_021954.4(GJA3):c.560C>T (p.Pro187Leu) single nucleotide variant Cataract 14 multiple types [RCV000018501] Chr13:20142729 [GRCh38]
Chr13:20716868 [GRCh37]
Chr13:13q12.11		 pathogenic|likely pathogenic
NM_021954.4(GJA3):c.227G>A (p.Arg76His) single nucleotide variant Cataract 14 multiple types [RCV000018502] Chr13:20143062 [GRCh38]
Chr13:20717201 [GRCh37]
Chr13:13q12.11		 pathogenic|likely pathogenic
NM_021954.4(GJA3):c.563A>C (p.Asn188Thr) single nucleotide variant Cataract 14 multiple types [RCV000043647] Chr13:20142726 [GRCh38]
Chr13:20716865 [GRCh37]
Chr13:13q12.11		 pathogenic|likely pathogenic
NM_021954.4(GJA3):c.5G>A (p.Gly2Asp) single nucleotide variant Cataract 14 multiple types [RCV000043648] Chr13:20143284 [GRCh38]
Chr13:20717423 [GRCh37]
Chr13:13q12.11		 pathogenic|likely pathogenic
NM_021954.4(GJA3):c.563A>T (p.Asn188Ile) single nucleotide variant Cataract 14 multiple types [RCV000043649] Chr13:20142726 [GRCh38]
Chr13:20716865 [GRCh37]
Chr13:13q12.11		 pathogenic|uncertain significance
1 to 10 of 323 rows

Predicted Targets
Summary Value
Count of predictions:46606
Count of gene targets:16892
Count of transcripts:36943
Interacting mature miRNAs:hsa-miR-6862-3p, hsa-miR-6862-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
11 25 60 18 60 29 36 7 13 4 41 63 49 31 7 34 28 3


RefSeq Transcripts NR_107058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC145285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000614755
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1628,724,252 - 28,724,321 (+)Ensembl
RefSeq Acc Id: NR_107058
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381628,724,252 - 28,724,321 (+)NCBI
CHM1_11629,414,437 - 29,414,506 (-)NCBI
T2T-CHM13v2.01629,004,924 - 29,004,992 (+)NCBI
Sequence:


1 to 11 of 11 rows
Database
Acc Id
Source(s)
COSMIC MIR6862-2 COSMIC
Ensembl Genes ENSG00000278340 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000614755 ENTREZGENE
GTEx ENSG00000278340 GTEx
HGNC ID HGNC:50192 ENTREZGENE
Human Proteome Map MIR6862-2 Human Proteome Map
miRBase MI0026415 ENTREZGENE
NCBI Gene MIR6862-2 ENTREZGENE
RNAcentral URS0000759D25 RNACentral
  URS000075DA38 RNACentral
  URS000075DEBA RNACentral
1 to 11 of 11 rows