Znf69l (zinc finger protein 69 like) - Rat Genome Database

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Gene: Znf69l (zinc finger protein 69 like) Rattus norvegicus
Analyze
Symbol: Znf69l
Name: zinc finger protein 69 like
RGD ID: 7547607
Description: Predicted to enable identical protein binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF69 (zinc finger protein 69); INTERACTS WITH arsane (ortholog); arsenic atom (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC102555578; zinc finger protein 120-like
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83159,009,658 - 159,018,416 (-)NCBIGRCr8
mRatBN7.23138,545,521 - 138,560,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3138,544,658 - 138,557,896 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03145,874,270 - 145,884,211 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3145,882,819 - 145,883,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03152,235,464 - 152,244,392 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Znf69lRatalpha-mannosidosis  ISOZNF69 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of alpha-mannosidaseClinVarPMID:28492532
Znf69lRatCharcot-Marie-Tooth disease dominant intermediate B  ISOZNF69 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate BClinVarPMID:28492532
Znf69lRatepisodic ataxia type 2  ISOZNF69 (Homo sapiens)8554872ClinVar Annotator: match by term: Episodic ataxia type 2ClinVarPMID:28492532
Znf69lRatglutaric acidemia I  ISOZNF69 (Homo sapiens)8554872ClinVar Annotator: match by term: Glutaric aciduria and type 1ClinVarPMID:28492532

1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Znf69lRatarsane multiple interactionsISOZNF69 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of ZNF69 mRNACTDPMID:39836092
Znf69lRatarsenic atom multiple interactionsISOZNF69 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of ZNF69 mRNACTDPMID:39836092
Znf69lRatbenzo[a]pyrene affects methylationISOZNF69 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of ZNF69 promoterCTDPMID:27901495
Znf69lRatbenzo[a]pyrene decreases methylationISOZNF69 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of ZNF69 5' UTRCTDPMID:27901495
Znf69lRatbisphenol A increases expressionISOZNF69 (Homo sapiens)6480464bisphenol A results in increased expression of ZNF69 mRNACTDPMID:31715268
Znf69lRatcrocidolite asbestos decreases expressionISOZNF69 (Homo sapiens)6480464Asbestos and Crocidolite results in decreased expression of ZNF69 mRNACTDPMID:29523930
Znf69lRatcyclosporin A decreases expressionISOZNF69 (Homo sapiens)6480464Cyclosporine results in decreased expression of ZNF69 mRNACTDPMID:25562108 and PMID:27989131
Znf69lRatdicrotophos decreases expressionISOZNF69 (Homo sapiens)6480464dicrotophos results in decreased expression of ZNF69 mRNACTDPMID:28302478
Znf69lRatdoxorubicin decreases expressionISOZNF69 (Homo sapiens)6480464Doxorubicin results in decreased expression of ZNF69 mRNACTDPMID:29803840
Znf69lRatGSK-J4 decreases expressionISOZNF69 (Homo sapiens)6480464GSK-J4 results in decreased expression of ZNF69 mRNACTDPMID:29301935
Znf69lRatmanganese atom multiple interactionsISOZNF69 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of ZNF69 mRNACTDPMID:39836092
Znf69lRatmanganese(0) multiple interactionsISOZNF69 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of ZNF69 mRNACTDPMID:39836092
Znf69lRatmanganese(II) chloride multiple interactionsISOZNF69 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of ZNF69 mRNACTDPMID:39836092
Znf69lRatsilicon dioxide decreases expressionISOZNF69 (Homo sapiens)6480464Silicon Dioxide analog results in decreased expression of ZNF69 mRNACTDPMID:25895662
Znf69lRatsodium arsenite multiple interactionsISOZNF69 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of ZNF69 mRNACTDPMID:39836092
Znf69lRattemozolomide decreases expressionISOZNF69 (Homo sapiens)6480464Temozolomide results in decreased expression of ZNF69 mRNACTDPMID:31758290
Znf69lRattriphenyl phosphate affects expressionISOZNF69 (Homo sapiens)6480464triphenyl phosphate affects the expression of ZNF69 mRNACTDPMID:37042841
Znf69lRatvalproic acid decreases expressionISOZNF69 (Homo sapiens)6480464Valproic Acid results in decreased expression of ZNF69 mRNACTDPMID:29154799

1 to 18 of 18 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Znf69lRatregulation of DNA-templated transcription involved_inIEAInterPro:IPR001909 and InterPro:IPR0360511600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Znf69lRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Znf69l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83159,009,658 - 159,018,416 (-)NCBIGRCr8
mRatBN7.23138,545,521 - 138,560,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3138,544,658 - 138,557,896 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03145,874,270 - 145,884,211 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3145,882,819 - 145,883,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03152,235,464 - 152,244,392 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map3q41NCBI
ZNF69
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,887,782 - 11,980,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,887,782 - 11,914,329 (+)EnsemblGRCh38hg38GRCh38
GRCh371911,998,597 - 12,025,371 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,859,670 - 11,886,144 (+)NCBINCBI36Build 36hg18NCBI36
Build 341911,859,669 - 11,886,130NCBI
Celera1911,893,044 - 11,919,740 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,573,266 - 11,599,866 (+)NCBIHuRef
CHM1_11911,998,499 - 12,025,199 (+)NCBICHM1_1
T2T-CHM13v2.01912,015,990 - 12,108,415 (+)NCBIT2T-CHM13v2.0

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Variants in Znf69l
113 total Variants

1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat

1 to 10 of 30 rows



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 1 16 24 22 15 6 15 44 9 14 19 27 7


RefSeq Transcripts XM_006235202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000042110   ⟹   ENSRNOP00000048165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3145,882,819 - 145,883,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107773   ⟹   ENSRNOP00000085750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3138,544,658 - 138,557,896 (-)Ensembl
RefSeq Acc Id: XM_039106633   ⟹   XP_038962561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83159,009,658 - 159,018,416 (-)NCBI
mRatBN7.23138,549,133 - 138,560,500 (-)NCBI
Protein RefSeqs XP_038962561 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085750.1
Ensembl Acc Id: ENSRNOP00000048165   ⟸   ENSRNOT00000042110
RefSeq Acc Id: XP_038962561   ⟸   XM_039106633
Ensembl Acc Id: ENSRNOP00000085750   ⟸   ENSRNOT00000107773
KRAB

Name Modeler Protein Id AA Range Protein Structure
AF-F1LU63-F1-model_v2 AlphaFold F1LU63 1-63 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-47425 BioCyc
Ensembl Genes ENSRNOG00000050230 Ensembl
  ENSRNOG00000065847 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000107773.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2-type UniProtKB/TrEMBL
NCBI Gene LOC102555578 ENTREZGENE
PANTHER RIKEN CDNA 6720489N17 GENE-RELATED UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
PhenoGen Znf69l PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050230 RatGTEx
  ENSRNOG00000065847 RatGTEx
SMART KRAB UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
UniProt A0A8I5ZZY0_RAT UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-02-24 Znf69l  zinc finger protein 69 like  ZNF69l  zinc finger protein 69 like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 ZNF69l  zinc finger protein 69 like  LOC102555578  zinc finger protein 120-like  Symbol and Name Changed 1299863 APPROVED
2013-12-17 LOC102555578  zinc finger protein 120-like      Symbol and Name status set to provisional 70820 PROVISIONAL