Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ip6k1 | Mouse | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IP6K1 mRNA | CTD | PMID:36331819 | Ip6k1 | Mouse | 1,2,4-trimethylbenzene | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | pseudocumene results in decreased expression of IP6K1 protein | CTD | PMID:17337753 | Ip6k1 | Mouse | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of IP6K1 mRNA | CTD | PMID:22206623 | Ip6k1 | Mouse | 17beta-estradiol 3-benzoate | increases methylation | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | estradiol 3-benzoate results in increased methylation of IP6K1 promoter | CTD | PMID:27415467 | Ip6k1 | Mouse | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | Ip6k1 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IP6K1 mRNA | CTD | PMID:33387578 | Ip6k1 | Mouse | 2,6-dinitrotoluene | affects expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of IP6K1 mRNA | CTD | PMID:21346803 | Ip6k1 | Mouse | 2-methylcholine | affects expression | ISO | IP6K1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of IP6K1 mRNA | CTD | PMID:21179406 | Ip6k1 | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of IP6K1 mRNA | CTD | PMID:30047161 | Ip6k1 | Mouse | acrolein | multiple interactions | ISO | IP6K1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of IP6K1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of IP6K1 mRNA | CTD | PMID:32699268 | Ip6k1 | Mouse | acrylamide | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Acrylamide results in decreased expression of IP6K1 mRNA | CTD | PMID:28959563 | Ip6k1 | Mouse | acrylamide | increases expression | ISO | IP6K1 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of IP6K1 mRNA | CTD | PMID:32763439 | Ip6k1 | Mouse | alpha-pinene | multiple interactions | ISO | IP6K1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of IP6K1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of IP6K1 mRNA | CTD | PMID:32699268 | Ip6k1 | Mouse | ammonium chloride | affects expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of IP6K1 mRNA | CTD | PMID:16483693 | Ip6k1 | Mouse | atrazine | decreases expression | ISO | IP6K1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of IP6K1 mRNA | CTD | PMID:22378314 | Ip6k1 | Mouse | bisphenol A | increases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of IP6K1 mRNA | CTD | PMID:25181051 more ... | Ip6k1 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of IP6K1 mRNA | CTD | PMID:33221593 | Ip6k1 | Mouse | bisphenol A | increases methylation | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of IP6K1 gene | CTD | PMID:28505145 | Ip6k1 | Mouse | buspirone | increases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Buspirone results in increased expression of IP6K1 mRNA | CTD | PMID:24136188 | Ip6k1 | Mouse | cadmium dichloride | increases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of IP6K1 mRNA | CTD | PMID:33453195 | Ip6k1 | Mouse | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes and Carbon results in decreased expression of IP6K1 mRNA | CTD | PMID:25554681 | Ip6k1 | Mouse | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of IP6K1 mRNA | CTD | PMID:37019170 | Ip6k1 | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IP6K1 gene | CTD | PMID:20938992 | Ip6k1 | Mouse | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of IP6K1 mRNA | CTD | PMID:28472532 | Ip6k1 | Mouse | copper(II) sulfate | decreases expression | ISO | IP6K1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of IP6K1 mRNA | CTD | PMID:19549813 | Ip6k1 | Mouse | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of IP6K1 mRNA | CTD | PMID:30319688 | Ip6k1 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | Ip6k1 | Mouse | gentamycin | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of IP6K1 mRNA | CTD | PMID:22061828 | Ip6k1 | Mouse | hydrogen peroxide | affects expression | ISO | IP6K1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of IP6K1 mRNA | CTD | PMID:21179406 | Ip6k1 | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IP6K1 gene | CTD | PMID:20938992 | Ip6k1 | Mouse | LY294002 | decreases activity | ISO | IP6K1 (Homo sapiens) | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of IP6K1 protein | CTD | PMID:29042286 | Ip6k1 | Mouse | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of IP6K1 mRNA | CTD | PMID:26307267 | Ip6k1 | Mouse | methidathion | increases expression | EXP | | 6480464 | methidathion results in increased expression of IP6K1 mRNA | CTD | PMID:34813904 | Ip6k1 | Mouse | methimazole | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of IP6K1 mRNA | CTD | PMID:30047161 | Ip6k1 | Mouse | methylphenidate | increases expression | EXP | | 6480464 | Methylphenidate results in increased expression of IP6K1 mRNA | CTD | PMID:22470460 | Ip6k1 | Mouse | Mono-carboxy isooctyl phthalate | affects expression | ISO | IP6K1 (Homo sapiens) | 6480464 | mono(carboxy-isooctyl)phthalate affects the expression of IP6K1 mRNA | CTD | PMID:34478338 | Ip6k1 | Mouse | ozone | multiple interactions | ISO | IP6K1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of IP6K1 mRNA more ... | CTD | PMID:32699268 | Ip6k1 | Mouse | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of IP6K1 mRNA | CTD | PMID:34911549 | Ip6k1 | Mouse | paclitaxel | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Paclitaxel results in decreased expression of IP6K1 mRNA | CTD | PMID:15585946 | Ip6k1 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of IP6K1 mRNA | CTD | PMID:17562736 | Ip6k1 | Mouse | paracetamol | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of IP6K1 mRNA | CTD | PMID:33387578 | Ip6k1 | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IP6K1 mRNA | CTD | PMID:36331819 | Ip6k1 | Mouse | phenylarsine oxide | decreases activity | ISO | IP6K1 (Homo sapiens) | 6480464 | oxophenylarsine results in decreased activity of IP6K1 protein | CTD | PMID:29042286 | Ip6k1 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of IP6K1 mRNA | CTD | PMID:23811191 | Ip6k1 | Mouse | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of IP6K1 mRNA | CTD | PMID:21278054 | Ip6k1 | Mouse | sulfadimethoxine | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of IP6K1 mRNA | CTD | PMID:30047161 | Ip6k1 | Mouse | tetrachloromethane | increases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of IP6K1 protein | CTD | PMID:16845489 | Ip6k1 | Mouse | titanium dioxide | increases methylation | EXP | | 6480464 | titanium dioxide results in increased methylation of IP6K1 gene | CTD | PMID:35295148 | Ip6k1 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of IP6K1 gene | CTD | PMID:35295148 | Ip6k1 | Mouse | tremolite asbestos | decreases expression | EXP | | 6480464 | tremolite results in decreased expression of IP6K1 mRNA | CTD | PMID:29279043 | Ip6k1 | Mouse | triphenyl phosphate | affects expression | ISO | IP6K1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of IP6K1 mRNA | CTD | PMID:37042841 | Ip6k1 | Mouse | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of IP6K1 mRNA | CTD | PMID:33045310 | Ip6k1 | Mouse | U-73122 | decreases activity | ISO | IP6K1 (Homo sapiens) | 6480464 | 1-(6-((3-methoxyestra-1 more ... | CTD | PMID:29042286 | Ip6k1 | Mouse | undecane | decreases expression | ISO | Ip6k1 (Rattus norvegicus) | 6480464 | undecane results in decreased expression of IP6K1 protein | CTD | PMID:17337753 | Ip6k1 | Mouse | urethane | increases expression | ISO | IP6K1 (Homo sapiens) | 6480464 | Urethane results in increased expression of IP6K1 mRNA | CTD | PMID:28818685 | Ip6k1 | Mouse | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of IP6K1 mRNA | CTD | PMID:21427059 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
Imported Annotations - SMPDB
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Cellular Component
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Molecular Function
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 3. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 4. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 5. | MGD IEA | MGD IEA |
| 6. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 7. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 8. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 10. | Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. | Saiardi A, etal., Curr Biol 1999 Nov 18;9(22):1323-6. |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11502751 | PMID:12477932 | PMID:14610273 | PMID:14681479 | PMID:15368895 | PMID:15489334 | PMID:15604408 |
| PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:16778019 | PMID:17967808 | PMID:18268345 | PMID:18799693 | PMID:19614566 | PMID:21122108 | PMID:21145457 | PMID:21685907 | PMID:21873635 |
| PMID:22076377 | PMID:23255604 | PMID:23322705 | PMID:23439485 | PMID:23610437 | PMID:23725456 | PMID:23782934 | PMID:24191012 | PMID:25349427 | PMID:26953345 | PMID:27140681 | PMID:27373682 |
| PMID:27474409 | PMID:27701146 | PMID:28154132 | PMID:28577302 | PMID:28743739 | PMID:29282838 | PMID:29522819 | PMID:29688375 | PMID:30718399 | PMID:32252022 | PMID:32325033 | PMID:32381051 |
| PMID:32554809 | PMID:33115740 | PMID:33821962 | PMID:34757046 | PMID:35216174 | PMID:35936490 | PMID:37742721 | PMID:38317282 | PMID:38350944 |
Genomics
Comparative Map Data
| Ip6k1 (Mus musculus - house mouse) |
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| IP6K1 (Homo sapiens - human) |
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| Ip6k1 (Rattus norvegicus - Norway rat) |
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| Ip6k1 (Chinchilla lanigera - long-tailed chinchilla) |
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| IP6K1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| IP6K1 (Canis lupus familiaris - dog) |
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| Ip6k1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| IP6K1 (Sus scrofa - pig) |
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| IP6K1 (Chlorocebus sabaeus - green monkey) |
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| Ip6k1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Ip6k1
1300 total Variants 
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