Wap (whey acidic protein) - Rat Genome Database

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Gene: Wap (whey acidic protein) Mus musculus
Analyze
No known orthologs.
Symbol: Wap
Name: whey acidic protein
RGD ID: 733824
MGI Page MGI
Description: Enables nutrient reservoir activity. Predicted to be involved in antibacterial humoral response and innate immune response. Located in extracellular region. Is expressed in mammary gland.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC25317
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,585,483 - 6,588,654 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,585,482 - 6,588,637 (-)EnsemblGRCm39 Ensembl
GRCm38116,635,483 - 6,638,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,635,482 - 6,638,637 (-)EnsemblGRCm38mm10GRCm38
MGSCv37116,535,486 - 6,538,652 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,535,485 - 6,538,633 (-)NCBIMGSCv36mm8
MGSCv36116,519,950 - 6,523,096 (-)NCBIMGSCv36mm8
Celera1118,708,711 - 18,708,866 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WapMouseAnimal Mammary Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
WapMousecarcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
WapMouseExperimental Mammary Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942

1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WapMouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of WAP mRNACTDPMID:28960355
WapMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of WAP mRNACTDPMID:18343893
WapMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of WAP mRNACTDPMID:15328365|PMID:16611356|PMID:17942748
WapMouse2,3,7,8-Tetrachlorodibenzofuran affects expressionEXP 64804642,3,7,8-tetrachlorodibenzofuran affects the expression of WAP mRNACTDPMID:18343893
WapMouse7,12-dimethyltetraphene increases expressionEXP 64804649,10-Dimethyl-1,2-benzanthracene results in increased expression of WAP proteinCTDPMID:38307155
WapMousebeta-naphthoflavone multiple interactionsEXP 6480464AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of WAP mRNA]; more ...CTDPMID:29521512
WapMousebeta-naphthoflavone decreases expressionEXP 6480464beta-Naphthoflavone results in decreased expression of WAP mRNACTDPMID:29521512
WapMousedexamethasone multiple interactionsEXP 6480464[PRL protein co-treated with Dexamethasone] results in increased expression of WAP mRNA; beta-Naphthoflavone inhibits the more ...CTDPMID:29521512
WapMouseoxybenzone decreases expressionEXP 6480464oxybenzone results in decreased expression of WAP mRNA; oxybenzone results in decreased expression of WAP more ...CTDPMID:32946892
WapMouseparacetamol affects expressionEXP 6480464Acetaminophen affects the expression of WAP mRNACTDPMID:17562736
WapMousetitanium dioxide decreases expressionEXP 6480464titanium dioxide results in decreased expression of WAP mRNACTDPMID:35295148
WapMousetriptonide increases expressionEXP 6480464triptonide results in increased expression of WAP mRNACTDPMID:33045310

1 to 12 of 12 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WapMouseantibacterial humoral response involved_inIBAPANTHER:PTN001835125|UniProtKB:P03973|MGI:1092972290270 GO_CentralGO_REF:0000033
WapMouseinnate immune response involved_inIBAPANTHER:PTN001835125|MGI:1092972290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WapMouseextracellular region located_inIDA 2290270 PMID:16106354MGIPMID:16106354
WapMouseextracellular space is_active_inIBAPANTHER:PTN001066578|MGI:109297|UniProtKB:P03973|MGI:19133572290270 GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WapMousenutrient reservoir activity enablesIMPMGI:35844302290270 PMID:16106354MGIPMID:16106354
WapMousepeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-06462290270 UniProtGO_REF:0000043
WapMouseserine-type endopeptidase inhibitor activity enablesIBAPANTHER:PTN001066578|UniProtKB:P039732290270 GO_CentralGO_REF:0000033

1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WapMouseabnormal milk composition  IAGP 5509061 MGIPMID:16106354
WapMousedecreased cardiac muscle contractility  IAGP 5509061 MGIPMID:14661057
WapMousedecreased tumor latency  IAGP 5509061 MGIPMID:22034435
WapMousedecreased tumor-free survival time  IAGP 5509061 MGIPMID:19174523
WapMouseincreased mammary adenocarcinoma incidence  IAGP 5509061 MGIPMID:11494122
WapMouseincreased mammary adenocarcinoma incidence  IAGP 5509061 MGIPMID:18443292
WapMouseincreased mammary adenocarcinoma incidence  IAGP 5509061 MGIPMID:14661057
WapMouseincreased mammary adenocarcinoma incidence  IAGP 5509061 MGIPMID:19174523
WapMouseincreased mammary gland tumor incidence  IAGP 5509061 MGIPMID:19174523
WapMouseincreased tumor latency  IAGP 5509061 MGIPMID:22034435
WapMouseno abnormal phenotype detected  IAGP 5509061 MGIPMID:19208431
WapMouseno abnormal phenotype detected  IAGP 5509061 MGIPMID:11494122
WapMousepremature death  IAGP 5509061 MGIPMID:14661057
1 to 13 of 13 rows

#
Reference Title
Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:2834201   PMID:6095207   PMID:6896059   PMID:6896234   PMID:6896688   PMID:6975276   PMID:7332524   PMID:7522033   PMID:7576607   PMID:7744960   PMID:8000430   PMID:8175886  
PMID:8637705   PMID:9021141   PMID:9115715   PMID:9322243   PMID:9841868   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11311554   PMID:11494122   PMID:12477932  
PMID:12759187   PMID:12907752   PMID:14661057   PMID:15007206   PMID:16106354   PMID:16141072   PMID:16141073   PMID:16751266   PMID:17187062   PMID:17541952   PMID:18255060   PMID:18443292  
PMID:18500724   PMID:18977342   PMID:19174523   PMID:19208431   PMID:20382704   PMID:20385773   PMID:20949099   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22034435   PMID:22588720  
PMID:23096997   PMID:24469394   PMID:24749073   PMID:25306215   PMID:26058079   PMID:27058754   PMID:30076411  



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Variants in Wap
114 total Variants

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:278
Interacting mature miRNAs:304
Transcripts:ENSMUST00000102910, ENSMUST00000127341, ENSMUST00000141868
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse

1 to 10 of 19 rows
Wap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
cM Map110.5UniSTS






1 to 16 of 16 rows
RefSeq Transcripts NM_011709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK142655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL603787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY923114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK000628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSMUST00000102910   ⟹   ENSMUSP00000099974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,585,482 - 6,588,637 (-)Ensembl
GRCm38.p6 Ensembl116,635,482 - 6,638,637 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,585,539 - 6,587,455 (-)Ensembl
GRCm38.p6 Ensembl116,635,539 - 6,637,455 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141868
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,585,482 - 6,587,466 (-)Ensembl
GRCm38.p6 Ensembl116,635,482 - 6,637,466 (-)Ensembl
RefSeq Acc Id: NM_011709   ⟹   NP_035839
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,585,483 - 6,588,649 (-)NCBI
GRCm38116,635,483 - 6,638,649 (-)NCBI
MGSCv37116,535,486 - 6,538,652 (-)RGD
Celera1118,708,711 - 18,708,866 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017314502   ⟹   XP_017169991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,586,597 - 6,588,654 (-)NCBI
GRCm38116,636,597 - 6,638,654 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035839   ⟸   NM_011709
- Peptide Label: precursor
- UniProtKB: Q61023 (UniProtKB/Swiss-Prot),   P70230 (UniProtKB/Swiss-Prot),   P01173 (UniProtKB/Swiss-Prot),   Q7M748 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169991   ⟸   XM_017314502
- Peptide Label: isoform X1
- UniProtKB: Q3UQ94 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099974   ⟸   ENSMUST00000102910
WAP

Name Modeler Protein Id AA Range Protein Structure
AF-P01173-F1-model_v2 AlphaFold P01173 1-134 view protein structure

RGD ID:6849602
Promoter ID:EP11089
Type:single initiation site
Name:MM_WAP
Description:Whey acidic protein, WAP gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 26; Rodent whey acidic protein
Experiment Methods:Sequencing of a full-length cDNA
Regulation:mammary glands; (induced by or strongly expressed in) PRL, (induced by or strongly expressed in) glucocorticoid
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37116,538,652 - 6,538,712EPD
MGSCv36116,538,652 - 6,538,712EPD
RGD ID:8673924
Promoter ID:EPDNEW_M14992
Type:multiple initiation site
Name:Wap_1
Description:Mus musculus whey acidic protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38116,638,649 - 6,638,709EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000000381 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000102910 ENTREZGENE
Gene3D-CATH 4.10.75.10 UniProtKB/Swiss-Prot
InterPro Elafin-like_sf UniProtKB/Swiss-Prot
  WAP_dom UniProtKB/Swiss-Prot
MGD MGI:98943 ENTREZGENE
NCBI Gene 22373 ENTREZGENE
Pfam WAP UniProtKB/Swiss-Prot
PhenoGen Wap PhenoGen
PROSITE WAP UniProtKB/Swiss-Prot
SMART WAP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57256 UniProtKB/Swiss-Prot
UniProt P01173 ENTREZGENE
  P70230 ENTREZGENE
  Q3UQ94 ENTREZGENE, UniProtKB/TrEMBL
  Q61023 ENTREZGENE
  Q7M748 ENTREZGENE, UniProtKB/TrEMBL
  WAP_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70230 UniProtKB/Swiss-Prot
  Q61023 UniProtKB/Swiss-Prot
1 to 20 of 20 rows