Wap (whey acidic protein) - Rat Genome Database

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Gene: Wap (whey acidic protein) Mus musculus
Analyze
No known orthologs.
Symbol: Wap
Name: whey acidic protein
RGD ID: 733824
MGI Page MGI
Description: Enables nutrient reservoir activity. Predicted to be involved in antibacterial humoral response and innate immune response. Located in extracellular region. Is expressed in mammary gland.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC25317
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,585,483 - 6,588,654 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,585,482 - 6,588,637 (-)EnsemblGRCm39 Ensembl
GRCm38116,635,483 - 6,638,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,635,482 - 6,638,637 (-)EnsemblGRCm38mm10GRCm38
MGSCv37116,535,486 - 6,538,652 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,535,485 - 6,538,633 (-)NCBIMGSCv36mm8
MGSCv36116,519,950 - 6,523,096 (-)NCBIMGSCv36mm8
Celera1118,708,711 - 18,708,866 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2834201   PMID:6095207   PMID:6896059   PMID:6896234   PMID:6896688   PMID:6975276   PMID:7332524   PMID:7522033   PMID:7576607   PMID:7744960   PMID:8000430   PMID:8175886  
PMID:8637705   PMID:9021141   PMID:9115715   PMID:9322243   PMID:9841868   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11311554   PMID:11494122   PMID:12477932  
PMID:12759187   PMID:12907752   PMID:14661057   PMID:15007206   PMID:16106354   PMID:16141072   PMID:16141073   PMID:16751266   PMID:17187062   PMID:17541952   PMID:18255060   PMID:18443292  
PMID:18500724   PMID:18977342   PMID:19174523   PMID:19208431   PMID:20382704   PMID:20385773   PMID:20949099   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22034435   PMID:22588720  
PMID:23096997   PMID:24469394   PMID:24749073   PMID:25306215   PMID:26058079   PMID:27058754   PMID:30076411  


Genomics

Variants

.
Variants in Wap
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:278
Interacting mature miRNAs:304
Transcripts:ENSMUST00000102910, ENSMUST00000127341, ENSMUST00000141868
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
Wap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
cM Map110.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000102910   ⟹   ENSMUSP00000099974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,585,482 - 6,588,637 (-)Ensembl
GRCm38.p6 Ensembl116,635,482 - 6,638,637 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,585,539 - 6,587,455 (-)Ensembl
GRCm38.p6 Ensembl116,635,539 - 6,637,455 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141868
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,585,482 - 6,587,466 (-)Ensembl
GRCm38.p6 Ensembl116,635,482 - 6,637,466 (-)Ensembl
RefSeq Acc Id: NM_011709   ⟹   NP_035839
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,585,483 - 6,588,649 (-)NCBI
GRCm38116,635,483 - 6,638,649 (-)NCBI
MGSCv37116,535,486 - 6,538,652 (-)RGD
Celera1118,708,711 - 18,708,866 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017314502   ⟹   XP_017169991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,586,597 - 6,588,654 (-)NCBI
GRCm38116,636,597 - 6,638,654 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035839   ⟸   NM_011709
- Peptide Label: precursor
- UniProtKB: Q61023 (UniProtKB/Swiss-Prot),   P70230 (UniProtKB/Swiss-Prot),   P01173 (UniProtKB/Swiss-Prot),   Q7M748 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169991   ⟸   XM_017314502
- Peptide Label: isoform X1
- UniProtKB: Q3UQ94 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099974   ⟸   ENSMUST00000102910
Protein Domains
WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01173-F1-model_v2 AlphaFold P01173 1-134 view protein structure

Promoters
RGD ID:6849602
Promoter ID:EP11089
Type:single initiation site
Name:MM_WAP
Description:Whey acidic protein, WAP gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 26; Rodent whey acidic protein
Experiment Methods:Sequencing of a full-length cDNA
Regulation:mammary glands; (induced by or strongly expressed in) PRL, (induced by or strongly expressed in) glucocorticoid
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37116,538,652 - 6,538,712EPD
MGSCv36116,538,652 - 6,538,712EPD
RGD ID:8673924
Promoter ID:EPDNEW_M14992
Type:multiple initiation site
Name:Wap_1
Description:Mus musculus whey acidic protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38116,638,649 - 6,638,709EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98943 AgrOrtholog
Ensembl Genes ENSMUSG00000000381 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102910 ENTREZGENE
  ENSMUST00000102910.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.75.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAP_four-disulfide_core UniProtKB/TrEMBL
KEGG Report mmu:22373 UniProtKB/TrEMBL
MGD MGI:98943 ENTREZGENE
NCBI Gene 22373 ENTREZGENE
PANTHER WHEY ACDIC PROTEIN WAP UniProtKB/TrEMBL
  WHEY ACIDIC PROTEIN UniProtKB/TrEMBL
Pfam WAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wap PhenoGen
PROSITE WAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P01173 ENTREZGENE
  P70230 ENTREZGENE
  Q3UQ94 ENTREZGENE, UniProtKB/TrEMBL
  Q61023 ENTREZGENE
  Q7M748 ENTREZGENE, UniProtKB/TrEMBL
  WAP_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70230 UniProtKB/Swiss-Prot
  Q61023 UniProtKB/Swiss-Prot