Entpd6 (ectonucleoside triphosphate diphosphohydrolase 6)

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Gene: Entpd6 (ectonucleoside triphosphate diphosphohydrolase 6) Rattus norvegicus

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Symbol:

Entpd6

Name:

ectonucleoside triphosphate diphosphohydrolase 6

RGD ID:

619725

Description:

Enables pyrophosphatase activity. Involved in response to calcium ion and response to magnesium ion. Located in cell surface and extracellular space. Orthologous to human ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; amphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CD39 antigen-like 2; NTPDase 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Entpd6^{Tn(sb-T2/Bart3)2.174Mcwi}

Genetic Models:

F344-Entpd6^{Tn(sb-T2/Bart3)2.174Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	160,036,055 - 160,058,580 (+)	NCBI		GRCr8
mRatBN7.2	3	139,575,659 - 139,598,163 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	139,575,686 - 139,598,154 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	143,471,519 - 143,494,099 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	152,055,255 - 152,077,835 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	149,804,015 - 149,826,553 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	146,546,424 - 146,568,828 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	146,546,387 - 146,568,825 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	152,905,464 - 152,927,857 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	141,385,480 - 141,407,860 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	141,291,052 - 141,313,433 (+)	NCBI
Celera	3	138,337,640 - 138,359,993 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

obesity (ISO)

seminoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

cisplatin (ISO)

clobetasol (ISO)

dexamethasone (ISO)

doxorubicin (ISO)

ethanol (ISO)

fipronil (EXP)

furan (EXP)

indometacin (ISO)

nickel sulfate (ISO)

paracetamol (EXP,ISO)

rotenone (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nucleoside diphosphate catabolic process (IBA)

response to calcium ion (IDA)

response to magnesium ion (IDA)

Cellular Component

cell surface (IDA)

extracellular region (ISO)

extracellular space (IDA)

Golgi apparatus (IBA,ISO)

Golgi membrane (IEA)

membrane (IBA)

plasma membrane (ISO)

Molecular Function

CDP phosphatase activity (IDA,ISO)

GDP phosphatase activity (IBA,IDA,ISO)

guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity (IDA)

IDP phosphatase activity (IDA,ISO)

nucleoside diphosphate phosphatase activity (IDA,ISO)

ribonucleoside triphosphate phosphatase activity (IBA,IDA)

UDP phosphatase activity (IBA,IDA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Sequencing, functional expression and characterization of rat NTPDase6, a nucleoside diphosphatase and novel member of the ecto-nucleoside triphosphate diphosphohydrolase family.	Braun N, etal., Biochem J 2000 Nov 1;351 Pt 3:639-47.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10948193	PMID:14529283	PMID:23302703	PMID:23376485

Genomics

Comparative Map Data

Entpd6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	160,036,055 - 160,058,580 (+)	NCBI		GRCr8
mRatBN7.2	3	139,575,659 - 139,598,163 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	139,575,686 - 139,598,154 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	143,471,519 - 143,494,099 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	152,055,255 - 152,077,835 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	149,804,015 - 149,826,553 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	146,546,424 - 146,568,828 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	146,546,387 - 146,568,825 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	152,905,464 - 152,927,857 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	141,385,480 - 141,407,860 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	141,291,052 - 141,313,433 (+)	NCBI
Celera	3	138,337,640 - 138,359,993 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

ENTPD6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	25,195,712 - 25,228,075 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	25,195,693 - 25,228,075 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	25,176,348 - 25,208,711 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	25,124,372 - 25,155,360 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	25,124,371 - 25,155,360	NCBI
Celera	20	25,250,075 - 25,281,095 (+)	NCBI		Celera
Cytogenetic Map	20	p11.21	NCBI
HuRef	20	25,133,642 - 25,164,663 (+)	NCBI		HuRef
CHM1_1	20	25,177,223 - 25,208,244 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	25,260,296 - 25,293,060 (+)	NCBI		T2T-CHM13v2.0

Entpd6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	150,590,959 - 150,613,595 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	150,590,962 - 150,613,595 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	150,748,980 - 150,771,675 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	150,749,042 - 150,771,675 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	150,574,817 - 150,597,410 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	150,440,590 - 150,463,114 (+)	NCBI		MGSCv36	mm8
Celera	2	151,982,124 - 152,004,717 (+)	NCBI		Celera
Cytogenetic Map	2	G3	NCBI
cM Map	2	74.74	NCBI

Entpd6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955415	31,219,909 - 31,245,107 (+)	NCBI	ChiLan1.0	ChiLan1.0

ENTPD6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	26,069,393 - 26,105,731 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	26,066,122 - 26,101,884 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	25,138,856 - 25,169,765 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	25,544,808 - 25,576,712 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	25,544,880 - 25,576,707 (+)	Ensembl	panpan1.1		panPan2

ENTPD6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	1,374,793 - 1,422,625 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	1,374,199 - 1,420,802 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	1,404,549 - 1,450,380 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	1,615,237 - 1,661,162 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	1,615,277 - 1,661,177 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	1,456,204 - 1,501,946 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	1,580,817 - 1,626,596 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	1,548,077 - 1,593,906 (+)	NCBI		UU_Cfam_GSD_1.0

Entpd6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	147,178,218 - 147,207,324 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936620	598,592 - 627,822 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936620	598,677 - 627,766 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENTPD6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	30,908,252 - 30,934,083 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	30,908,747 - 30,930,774 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ENTPD6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666078	7,827,280 - 7,857,456 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Entpd6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624939	313,768 - 333,694 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624939	313,763 - 333,640 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Entpd6
102 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	476
Count of miRNA genes:	230
Interacting mature miRNAs:	285
Transcripts:	ENSRNOT00000009946
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

RH131966

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	139,597,957 - 139,598,143 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	146,568,623 - 146,568,808	NCBI	Rnor6.0
Rnor_5.0	3	152,927,654 - 152,927,839	UniSTS	Rnor5.0
RGSC_v3.4	3	141,407,657 - 141,407,842	UniSTS	RGSC3.4
Celera	3	138,359,790 - 138,359,975	UniSTS
RH 3.4 Map	3	1197.22	UniSTS
Cytogenetic Map	3	q41	UniSTS

UniSTS:234554

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	139,597,847 - 139,598,051 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	146,568,513 - 146,568,716	NCBI	Rnor6.0
Rnor_5.0	3	152,927,544 - 152,927,747	UniSTS	Rnor5.0
RGSC_v3.4	3	141,407,547 - 141,407,750	UniSTS	RGSC3.4
Celera	3	138,359,680 - 138,359,883	UniSTS
Cytogenetic Map	3	q41	UniSTS

Genetic Models

This gene Entpd6 is modified in the following models/strains:

F344-Entpd6^{Tn(sb-T2/Bart3)2.174Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ277748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009946 ⟹ ENSRNOP00000009946

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	139,575,686 - 139,598,154 (+)	Ensembl
Rnor_6.0 Ensembl	3	146,546,387 - 146,568,825 (+)	Ensembl

RefSeq Acc Id:

NM_053498 ⟹ NP_445950

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	160,036,119 - 160,058,580 (+)	NCBI
mRatBN7.2	3	139,575,700 - 139,598,161 (+)	NCBI
Rnor_6.0	3	146,546,446 - 146,568,826 (+)	NCBI
Rnor_5.0	3	152,905,464 - 152,927,857 (+)	NCBI
RGSC_v3.4	3	141,385,480 - 141,407,860 (+)	RGD
Celera	3	138,337,640 - 138,359,993 (+)	RGD

Sequence:

show sequence

ATCGGCTAAGGTCTGGTTCCACGCGTTGAGGCTCTGTTGACGCGGACTGGCGCTGGAGAGCCAA
GCGCTCGGTGTGTGGTCGCTGTCTGCCTCCAGCACCGGCTACATAGTCCCTAGCAGACTGAGAA
ATGAGAAAAATACCAAACCATGGGACCTTGCGGATGACGAAGGTGGCGTATCCCCTGGGACTGT
GCGTGGGCCTGTTCATCTATGTTGCCTATATCAAGTGGCACCGGGCCTCCGCCGCCCAGGCCTT
CTTCACCATTGCTGGGGCTGCCTCAGGAGTGCGGTGGACCCAACAGGCCTTCAGCTCTCCAGAC
TCAGCCACACGTGGTCACGAGGTCTTCTATGGGATCATGTTTGATGCCGGGAGTACCGGCACCC
GCATCCACGTCTTCCAGTTTGCCCGGCCACCTGGAGAAACTCCCACCTTGACCCACGAAACCTT
CAAAGCTCTGAAGCCTGGGCTTTCTGCGTATGCCGATGATGTTGAAAAGAGCGCCCAAGGGATC
CAGGAGCTTCTGAATGTCGCCAAGCAACACATTCCATACGACTTCTGGAAGGCCACCCCTCTGG
TTCTCAAGGCCACAGCTGGTCTGCGCCTGCTGCCGGGAGAAAAGGCTCAGAAGTTGCTGCAAAA
GGTGAAGGAGGTGTTTAAGGCATCACCCTTCCTTGTAGGGGATGACTGTGTTTCCATCATGAAT
GGCACAGATGAAGGTGTTTCGGCTTGGATCACTGTCAACTTCCTGACAGGCAGTCTGAAGACCC
CAGGAAGCAGCAGTGTGGGCATGCTGGACTTGGGCGGAGGATCCACTCAGATCACCTTCCTCCC
ACGTGTCGAGGGTACCCTGCAGGCCTCCCCACCCGGCCACCTGACAGCGCTGCAGATGTTTAAC
AGGACTTTCAAGCTGTATTCCTACAGCTACCTGGGGCTGGGACTGATGTCGGCACGACTGGCTA
TCTTGGGTGGTGTGGAGGGGAAACCTGCTGAGGATGACAAGGAACTGGTCAGCCCCTGTCTGTC
TCCCCGGTTCAGAGGAAAGTGGGAGCATGCGGAGGTCACCTATAGAATTTCAGGACAGAAGGCA
GTGGGCCTCTACGAGCTGTGTGCCAGCAGGGTATCAGAAGTCCTCCGCAATAAAGTACACAGGA
CAGAAGAGGCGCAGCACGTGGACTTCTATGCGTTTTCCTACTACTACGACCTTGCTGCCAGCTT
TGGCCTTATAGATGCAGAGAAAGGAGGCAGCCTTGTAGTTGGAGACTTTGAGATAGCAGCCAAG
TATGTCTGCCGCACTCTGGAGACACAGCCTCCAAGCAGCCCCTTTGCTTGCATGGACCTCACCT
ACATCAGCCTCCTGCTCCACGAGTTTGGTTTTCCCGGGGACAAGGTACTGAAGCTGGCTCGGAA
AATTGACAATGTTGAAACCAGCTGGGCTCTGGGGGCTATTTTTCATTACATCGACTCCCTGAAG
AGACAGAAGGTTCCTGCCTTGTAGCAGCCTCGAACTAGTCCCCACCCTAGCCAGATTTCCGAGG
CTCCCAACTCCACGGACCCCTCTATCTTGGAAGTGACACCATCCTTGAGGAGCCTGCATCTGGT
TGAGACCCGCCTCTGTGCCTGCAGTGTCATCTCCTGCAGATTTGCCTGGGACATGACCCATGTA
CTGGCTCTGCTACACCACACTAGCTGGGGCAGGGCCAGGGTAGGAATGCTGCCTGGCCTGAGGC
CATCTCCCTGTCTTACCCCCAAATGGGCGGGGAGCCAGCTGGGGCCCAGGGCACATGCTAAGGT
AGAGACGCAGCCCTGCTCTTATCCCGTCCGTGTGCAGGATTGTGGCTGCTTTTGTGTGTTTCTG
TGACTTGAGTCTTGTTTTGTCTCCCAGCCCCCGTTCCCTCATGAGTTGGGCCTCTCTGCCTTCC
CAGAGTTTGGCGAGATGAAGTAACTGGCCCAAACGCAGTGCAAGGGGAGCACATTTTGAGTGTG
GCCATCTCTTCCTCGGGATAGACGTGAAGTTACCTGGAGGTTTGCTGTCCCACCTTTGGATGGT
ATAGCATTCATTGATGTGGGGACATTGAGTAGGAAGGAGATGGGGCAGTGCCTCTTTATAGACC
TTTGCAGAGCATGTGGGTGTGAGCAGAGCTATGAGAATGTTCAGGGCTGCGTGCTCAAGTACTA
CCTTGCAAGCTGTGAGCGCTGTACGTTAAAACTGAGCCCCTCTTCTGGACACAGCGGTGTCCCC
GTGAATGTATTACTGCTATGAGCCACTTGCAGACCAGTGGGGCAGGTTAGAAAGCTCAGCCCTA
GAACCAGACTACCCCTCACCCCACCCTCCTTACTCGGCTGCAGCTGGCTTCCCCGTGGTCCCCT
CAGTGAATGTACAGTTCATAGAGTAAGCTGAGCCACCACCGTTCAACTCCAAATAAAGGTTTAC
AAGGGTTTCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006235218 ⟹ XP_006235280

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	160,036,118 - 160,058,578 (+)	NCBI
mRatBN7.2	3	139,575,700 - 139,598,163 (+)	NCBI
Rnor_6.0	3	146,546,424 - 146,568,828 (+)	NCBI
Rnor_5.0	3	152,905,464 - 152,927,857 (+)	NCBI

Sequence:

show sequence

TAGGCGGAGACAGCTCCTCCCGATCGGCTAAGGTCTGGTTCCACGCGTTGAGGCTCTGTTGACG
CGGACTGGCGCTGGAGAGCCAAGCGCTCGGTGTGTGGTCGCTGTCTGCCTCCAGGTACGCCACT
ACATGTCCTGAGGGGCCGAGGGCGCCGTGCAGGCACCGGCTACATAGTCCCTAGCAGACTGAGA
AATGAGAAAAATACCAAACCATGGGACCTTGCGGATGACGAAGGTGGCGTATCCCCTGGGACTG
TGCGTGGGCCTGTTCATCTATGTTGCCTATATCAAGTGGCACCGGGCCTCCGCCGCCCAGGCCT
TCTTCACCATTGCTGGGGCTGCCTCAGGAGTGCGGTGGACCCAACAGGCCTTCAGCTCTCCAGA
CTCAGCCACACGTGGTCACGAGGTCTTCTATGGGATCATGTTTGATGCCGGGAGTACCGGCACC
CGCATCCACGTCTTCCAGTTTGCCCGGCCACCTGGAGAAACTCCCACCTTGACCCACGAAACCT
TCAAAGCTCTGAAGCCTGGGCTTTCTGCGTATGCCGATGATGTTGAAAAGAGCGCCCAAGGGAT
CCAGGAGCTTCTGAATGTCGCCAAGCAACACATTCCATACGACTTCTGGAAGGCCACCCCTCTG
GTTCTCAAGGCCACAGCTGGTCTGCGCCTGCTGCCGGGAGAAAAGGCTCAGAAGTTGCTGCAAA
AGGTGAAGGAGGTGTTTAAGGCATCACCCTTCCTTGTAGGGGATGACTGTGTTTCCATCATGAA
TGGCACAGATGAAGGTGTTTCGGCTTGGATCACTGTCAACTTCCTGACAGGCAGTCTGAAGACC
CCAGGAAGCAGCAGTGTGGGCATGCTGGACTTGGGCGGAGGATCCACTCAGATCACCTTCCTCC
CACGTGTCGAGGGTACCCTGCAGGCCTCCCCACCCGGCCACCTGACAGCGCTGCAGATGTTTAA
CAGGACTTTCAAGCTGTATTCCTACAGCTACCTGGGGCTGGGACTGATGTCGGCACGACTGGCT
ATCTTGGGTGGTGTGGAGGGGAAACCTGCTGAGGATGACAAGGAACTGGTCAGCCCCTGTCTGT
CTCCCCGGTTCAGAGGAAAGTGGGAGCATGCGGAGGTCACCTATAGAATTTCAGGACAGAAGGC
AGTGGGCCTCTACGAGCTGTGTGCCAGCAGGGTATCAGAAGTCCTCCGCAATAAAGTACACAGG
ACAGAAGAGGCGCAGCACGTGGACTTCTATGCGTTTTCCTACTACTACGACCTTGCTGCCAGCT
TTGGCCTTATAGATGCAGAGAAAGGAGGCAGCCTTGTAGTTGGAGACTTTGAGATAGCAGCCAA
GTATGTCTGCCGCACTCTGGAGACACAGCCTCCAAGCAGCCCCTTTGCTTGCATGGACCTCACC
TACATCAGCCTCCTGCTCCACGAGTTTGGTTTTCCCGGGGACAAGGTACTGAAGCTGGCTCGGA
AAATTGACAATGTTGAAACCAGCTGGGCTCTGGGGGCTATTTTTCATTACATCGACTCCCTGAA
GAGACAGAAGGTTCCTGCCTTGTAGCAGCCTCGAACTAGTCCCCACCCTAGCCAGATTTCCGAG
GCTCCCAACTCCACGGACCCCTCTATCTTGGAAGTGACACCATCCTTGAGGAGCCTGCATCTGG
TTGAGACCCGCCTCTGTGCCTGCAGTGTCATCTCCTGCAGATTTGCCTGGGACATGACCCATGT
ACTGGCTCTGCTACACCACACTAGCTGGGGCAGGGCCAGGGTAGGAATGCTGCCTGGCCTGAGG
CCATCTCCCTGTCTTACCCCCAAATGGGCGGGGAGCCAGCTGGGGCCCAGGGCACATGCTAAGG
TAGAGACGCAGCCCTGCTCTTATCCCGTCCGTGTGCAGGATTGTGGCTGCTTTTGTGTGTTTCT
GTGACTTGAGTCTTGTTTTGTCTCCCAGCCCCCGTTCCCTCATGAGTTGGGCCTCTCTGCCTTC
CCAGAGTTTGGCGAGATGAAGTAACTGGCCCAAACGCAGTGCAAGGGGAGCACATTTTGAGTGT
GGCCATCTCTTCCTCGGGATAGACGTGAAGTTACCTGGAGGTTTGCTGTCCCACCTTTGGATGG
TATAGCATTCATTGATGTGGGGACATTGAGTAGGAAGGAGATGGGGCAGTGCCTCTTTATAGAC
CTTTGCAGAGCATGTGGGTGTGAGCAGAGCTATGAGAATGTTCAGGGCTGCGTGCTCAAGTACT
ACCTTGCAAGCTGTGAGCGCTGTACGTTAAAACTGAGCCCCTCTTCTGGACACAGCGGTGTCCC
CGTGAATGTATTACTGCTATGAGCCACTTGCAGACCAGTGGGGCAGGTTAGAAAGCTCAGCCCT
AGAACCAGACTACCCCTCACCCCACCCTCCTTACTCGGCTGCAGCTGGCTTCCCCGTGGTCCCC
TCAGTGAATGTACAGTTCATAGAGTAAGCTGAGCCACCACCGTTCAACTCCAAATAAAGGTTTA
CAAGGGTTTCTC

hide sequence

RefSeq Acc Id:

XM_063284740 ⟹ XP_063140810

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	160,036,085 - 160,058,578 (+)	NCBI

RefSeq Acc Id:

XR_010064708

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	160,036,055 - 160,052,414 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001416444	(Get FASTA)	NCBI Sequence Viewer
	NP_445950	(Get FASTA)	NCBI Sequence Viewer
	XP_006235280	(Get FASTA)	NCBI Sequence Viewer
	XP_063140810	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAC16598	(Get FASTA)	NCBI Sequence Viewer
	EDL86140	(Get FASTA)	NCBI Sequence Viewer
	EDL86141	(Get FASTA)	NCBI Sequence Viewer
	EDL86142	(Get FASTA)	NCBI Sequence Viewer
	EDL86143	(Get FASTA)	NCBI Sequence Viewer
	EDL86144	(Get FASTA)	NCBI Sequence Viewer
	EDL86145	(Get FASTA)	NCBI Sequence Viewer
	EDL86146	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009946.3
	ENSRNOP00055032861
	ENSRNOP00060001849
GenBank Protein	Q9ER31	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445950 ⟸ NM_053498

- UniProtKB:

Q9ER31 (UniProtKB/Swiss-Prot), A6KHG0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRKIPNHGTLRMTKVAYPLGLCVGLFIYVAYIKWHRASAAQAFFTIAGAASGVRWTQQAFSSPD
SATRGHEVFYGIMFDAGSTGTRIHVFQFARPPGETPTLTHETFKALKPGLSAYADDVEKSAQGI
QELLNVAKQHIPYDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVFKASPFLVGDDCVSIMN
GTDEGVSAWITVNFLTGSLKTPGSSSVGMLDLGGGSTQITFLPRVEGTLQASPPGHLTALQMFN
RTFKLYSYSYLGLGLMSARLAILGGVEGKPAEDDKELVSPCLSPRFRGKWEHAEVTYRISGQKA
VGLYELCASRVSEVLRNKVHRTEEAQHVDFYAFSYYYDLAASFGLIDAEKGGSLVVGDFEIAAK
YVCRTLETQPPSSPFACMDLTYISLLLHEFGFPGDKVLKLARKIDNVETSWALGAIFHYIDSLK
RQKVPAL

hide sequence

RefSeq Acc Id:

XP_006235280 ⟸ XM_006235218

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRKIPNHGTLRMTKVAYPLGLCVGLFIYVAYIKWHRASAAQAFFTIAGAASGVRWTQQAFSSPD
SATRGHEVFYGIMFDAGSTGTRIHVFQFARPPGETPTLTHETFKALKPGLSAYADDVEKSAQGI
QELLNVAKQHIPYDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVFKASPFLVGDDCVSIMN
GTDEGVSAWITVNFLTGSLKTPGSSSVGMLDLGGGSTQITFLPRVEGTLQASPPGHLTALQMFN
RTFKLYSYSYLGLGLMSARLAILGGVEGKPAEDDKELVSPCLSPRFRGKWEHAEVTYRISGQKA
VGLYELCASRVSEVLRNKVHRTEEAQHVDFYAFSYYYDLAASFGLIDAEKGGSLVVGDFEIAAK
YVCRTLETQPPSSPFACMDLTYISLLLHEFGFPGDKVLKLARKIDNVETSWALGAIFHYIDSLK
RQKVPAL

hide sequence

Ensembl Acc Id:

ENSRNOP00000009946 ⟸ ENSRNOT00000009946

RefSeq Acc Id:	XP_063140810 ⟸ XM_063284740
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ER31-F1-model_v2	AlphaFold	Q9ER31	1-455	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692517

Promoter ID:

EPDNEW_R3042

Type:

initiation region

Name:

Entpd6_1

Description:

ectonucleoside triphosphate diphosphohydrolase 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	146,546,432 - 146,546,492	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619725	AgrOrtholog
BioCyc Gene	G2FUF-47338	BioCyc
Ensembl Genes	ENSRNOG00000007427	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055023532	UniProtKB/Swiss-Prot
	ENSRNOG00060001847	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009946.6	UniProtKB/Swiss-Prot
	ENSRNOT00055040450	UniProtKB/Swiss-Prot
	ENSRNOT00060002839	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.420.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Exopolyphosphatase. Domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GDA1_CD39_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:85260	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	85260	ENTREZGENE
PANTHER	ADENOSINE/GUANOSINE DIPHOSPHATASE	UniProtKB/TrEMBL
	ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11782	UniProtKB/Swiss-Prot
Pfam	GDA1_CD39	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Entpd6	PhenoGen
PROSITE	GDA1_CD39_NTPASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007427	RatGTEx
	ENSRNOG00055023532	RatGTEx
	ENSRNOG00060001847	RatGTEx
UniProt	A6KHG0	ENTREZGENE, UniProtKB/TrEMBL
	A6KHG2_RAT	UniProtKB/TrEMBL
	A6KHG3_RAT	UniProtKB/TrEMBL
	A6KHG4_RAT	UniProtKB/TrEMBL
	A6KHG5_RAT	UniProtKB/TrEMBL
	ENTP6_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Entpd6	ectonucleoside triphosphate diphosphohydrolase 6			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Entpd6	ectonucleoside triphosphate diphosphohydrolase 6			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	preferentially hydrolyses nucleoside 5'-diphosphates	727304
gene_protein	455 amino acids; 50 (49.97) kDa	727304

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)