MIR4758 (microRNA 4758) - Rat Genome Database

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Gene: MIR4758 (microRNA 4758) Homo sapiens
Analyze
Symbol: MIR4758
Name: microRNA 4758
RGD ID: 5134096
HGNC Page HGNC:41836
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382062,332,487 - 62,332,557 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2062,332,487 - 62,332,557 (-)EnsemblGRCh38hg38GRCh38
GRCh372060,907,543 - 60,907,613 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map20q13.33NCBI
HuRef2057,684,442 - 57,684,512 (-)NCBIHuRef
CHM1_12060,808,696 - 60,808,766 (-)NCBICHM1_1
T2T-CHM13v2.02064,127,437 - 64,127,507 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR4758HumanAflatoxin B2 alpha decreases methylationEXP 6480464aflatoxin B2 results in decreased methylation of MIR4758 promoterCTDPMID:30157460
MIR4758Humanbenzo[a]pyrene affects methylationEXP 6480464Benzo(a)pyrene affects the methylation of MIR4758 promoterCTDPMID:30157460
MIR4758Humanbenzo[e]pyrene decreases methylationEXP 6480464benzo(e)pyrene results in decreased methylation of MIR4758 promoterCTDPMID:30157460
MIR4758Humandecabromodiphenyl ether decreases expressionEXP 6480464decabromobiphenyl ether results in decreased expression of MIR4758 mRNACTDPMID:34166751
MIR4758Humanmethapyrilene decreases methylationEXP 6480464Methapyrilene results in decreased methylation of MIR4758 promoterCTDPMID:30157460
MIR4758Humanvalproic acid decreases expressionEXP 6480464Valproic Acid results in decreased expression of MIR4758 mRNACTDPMID:39423997

PMID:16381832   PMID:21199797   PMID:23535732  



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Variants in MIR4758
1 total Variants

1 to 10 of 10 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 20q13.32-13.33(chr20:59041966-64277321)x3 copy number gain See cases [RCV000135805] Chr20:59041966..64277321 [GRCh38]
Chr20:57617021..62908674 [GRCh37]
Chr20:57050416..62379118 [NCBI36]
Chr20:20q13.32-13.33		 pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:56198032-64277321)x3 copy number gain See cases [RCV000138035] Chr20:56198032..64277321 [GRCh38]
Chr20:54773088..62908674 [GRCh37]
Chr20:54206495..62379118 [NCBI36]
Chr20:20q13.2-13.33		 pathogenic
GRCh38/hg38 20q13.33(chr20:61326549-64277326)x3 copy number gain See cases [RCV000139100] Chr20:61326549..64277326 [GRCh38]
Chr20:59901605..62908679 [GRCh37]
Chr20:59335000..62379123 [NCBI36]
Chr20:20q13.33		 pathogenic
GRCh38/hg38 20q13.31-13.33(chr20:57229415-64273089)x3 copy number gain See cases [RCV000141347] Chr20:57229415..64273089 [GRCh38]
Chr20:55804471..62904442 [GRCh37]
Chr20:55237878..62374886 [NCBI36]
Chr20:20q13.31-13.33		 pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:53236165-64284202)x3 copy number gain See cases [RCV000143584] Chr20:53236165..64284202 [GRCh38]
Chr20:51852704..62915555 [GRCh37]
Chr20:51286111..62385999 [NCBI36]
Chr20:20q13.2-13.33		 likely pathogenic
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33		 pathogenic
Single allele duplication not specified [RCV002286379] Chr20:61800345..63644611 [GRCh38]
Chr20:20q13.33		 uncertain significance
NM_005560.6(LAMA5):c.3444-12C>G single nucleotide variant not provided [RCV003057413] Chr20:62332492 [GRCh38]
Chr20:60907548 [GRCh37]
Chr20:20q13.33		 likely benign
GRCh38/hg38 20q13.13-13.33(chr20:50805746-64334135) copy number gain 20q13.13qter duplication [RCV004555205] Chr20:50805746..64334135 [GRCh38]
Chr20:20q13.13-13.33		 pathogenic
1 to 10 of 10 rows

Predicted Targets
Summary Value
Count of predictions:64764
Count of gene targets:19535
Count of transcripts:50233
Interacting mature miRNAs:hsa-miR-4758-3p, hsa-miR-4758-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2292864PRSTS43_HProstate tumor susceptibility QTL 43 (human)0.620.05Prostate tumor susceptibility204730303964444167Human
1300007BP29_HBlood pressure QTL 29 (human)Blood pressurehypertension susceptibility203653600562536005Human




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
10 25 27 22 34 6 11 4 3 2 20 41 43 23 5 8 7 2



Ensembl Acc Id: ENST00000577688
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2062,332,487 - 62,332,557 (-)Ensembl
RefSeq Acc Id: NR_039915
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382062,332,487 - 62,332,557 (-)NCBI
GRCh372060,907,543 - 60,907,613 (-)NCBI
HuRef2057,684,442 - 57,684,512 (-)NCBI
CHM1_12060,808,696 - 60,808,766 (-)NCBI
T2T-CHM13v2.02064,127,437 - 64,127,507 (-)NCBI
Sequence:


1 to 11 of 11 rows
Database
Acc Id
Source(s)
COSMIC MIR4758 COSMIC
Ensembl Genes ENSG00000284074 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000577688 ENTREZGENE
GTEx ENSG00000284074 GTEx
HGNC ID HGNC:41836 ENTREZGENE
Human Proteome Map MIR4758 Human Proteome Map
miRBase MI0017399 ENTREZGENE
NCBI Gene 100616340 ENTREZGENE
RNAcentral URS0000031E74 RNACentral
  URS0000378EED RNACentral
  URS000075D767 RNACentral
1 to 11 of 11 rows