MIR4317 (microRNA 4317) - Rat Genome Database

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Gene: MIR4317 (microRNA 4317) Homo sapiens
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Symbol: MIR4317
Name: microRNA 4317
RGD ID: 4109071
HGNC Page HGNC:38260
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38186,374,361 - 6,374,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl186,374,361 - 6,374,425 (-)EnsemblGRCh38hg38GRCh38
GRCh37186,374,360 - 6,374,424 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera186,259,651 - 6,259,715 (-)NCBICelera
Cytogenetic Map18p11.31NCBI
HuRef186,337,403 - 6,337,467 (-)NCBIHuRef
CHM1_1186,373,840 - 6,373,904 (-)NCBICHM1_1
T2T-CHM13v2.0186,534,825 - 6,534,889 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR4317Humandecabromodiphenyl ether increases expressionEXP 6480464decabromobiphenyl ether results in increased expression of MIR4317 mRNACTDPMID:34166751

PMID:16381832   PMID:19784364   PMID:28880489   PMID:30227870   PMID:31002131   PMID:32279128   PMID:34861581  



.

1 to 10 of 50 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 18p11.32-11.21(chr18:148963-14081888)x3 copy number gain See cases [RCV000051153] Chr18:148963..14081888 [GRCh38]
Chr18:148963..14081887 [GRCh37]
Chr18:138963..14071887 [NCBI36]
Chr18:18p11.32-11.21		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:149089-80234391)x3 copy number gain See cases [RCV000134110] Chr18:149089..80234391 [GRCh38]
Chr18:149089..77992274 [GRCh37]
Chr18:139089..76093265 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:148963-14081888)x4 copy number gain See cases [RCV000135515] Chr18:148963..14081888 [GRCh38]
Chr18:148963..14081887 [GRCh37]
Chr18:138963..14071887 [NCBI36]
Chr18:18p11.32-11.21		 pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:2425507-11904118)x3 copy number gain See cases [RCV000136590] Chr18:2425507..11904118 [GRCh38]
Chr18:2425506..11904117 [GRCh37]
Chr18:2415506..11894117 [NCBI36]
Chr18:18p11.32-11.21		 pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:148963-10900517)x1 copy number loss See cases [RCV000137105] Chr18:148963..10900517 [GRCh38]
Chr18:148963..10900515 [GRCh37]
Chr18:138963..10890515 [NCBI36]
Chr18:18p11.32-11.21		 pathogenic
GRCh38/hg38 18p11.32-11.22(chr18:180229-10762632)x1 copy number loss See cases [RCV000136860] Chr18:180229..10762632 [GRCh38]
Chr18:180229..10762630 [GRCh37]
Chr18:170229..10752630 [NCBI36]
Chr18:18p11.32-11.22		 pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:118760-14089410)x4 copy number gain See cases [RCV000137456] Chr18:118760..14089410 [GRCh38]
Chr18:118760..14089409 [GRCh37]
Chr18:108760..14079409 [NCBI36]
Chr18:18p11.32-11.21		 pathogenic|conflicting data from submitters
GRCh38/hg38 18p11.32-11.21(chr18:118760-14089410)x1 copy number loss See cases [RCV000137457] Chr18:118760..14089410 [GRCh38]
Chr18:118760..14089409 [GRCh37]
Chr18:108760..14079409 [NCBI36]
Chr18:18p11.32-11.21		 pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:133157-14089410)x1 copy number loss See cases [RCV000138101] Chr18:133157..14089410 [GRCh38]
Chr18:133157..14089409 [GRCh37]
Chr18:123157..14079409 [NCBI36]
Chr18:18p11.32-11.21		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:118760-80254946)x3 copy number gain See cases [RCV000138656] Chr18:118760..80254946 [GRCh38]
Chr18:118760..78012829 [GRCh37]
Chr18:108760..76113817 [NCBI36]
Chr18:18p11.32-q23		 pathogenic|conflicting data from submitters
1 to 10 of 50 rows

Predicted Targets
Summary Value
Count of predictions:8503
Count of gene targets:4881
Count of transcripts:7948
Interacting mature miRNAs:hsa-miR-4317
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
1 1 3 3 1 2 2 10 1 1 17 15 2 1 5 1


RefSeq Transcripts NR_036205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AP005060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000637586
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl186,374,361 - 6,374,425 (-)Ensembl
RefSeq Acc Id: NR_036205
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38186,374,361 - 6,374,425 (-)NCBI
GRCh37186,374,360 - 6,374,424 (-)RGD
Celera186,259,651 - 6,259,715 (-)RGD
HuRef186,337,403 - 6,337,467 (-)RGD
CHM1_1186,373,840 - 6,373,904 (-)NCBI
T2T-CHM13v2.0186,534,825 - 6,534,889 (-)NCBI
Sequence:


1 to 11 of 11 rows
Database
Acc Id
Source(s)
COSMIC MIR4317 COSMIC
Ensembl Genes ENSG00000283532 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000637586 ENTREZGENE
GTEx ENSG00000283532 GTEx
HGNC ID HGNC:38260 ENTREZGENE
Human Proteome Map MIR4317 Human Proteome Map
miRBase MI0015850 ENTREZGENE
NCBI Gene 100422840 ENTREZGENE
PharmGKB PA165429051 PharmGKB
RNAcentral URS00005977B9 RNACentral
  URS000075C718 RNACentral
1 to 11 of 11 rows