MIR3156-2 (microRNA 3156-2) - Rat Genome Database
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Gene: MIR3156-2 (microRNA 3156-2) Homo sapiens
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Symbol: MIR3156-2
Name: microRNA 3156-2
RGD ID: 4108999
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3156-2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1814,830,166 - 14,830,242 (+)EnsemblGRCh38hg38GRCh38
GRCh381814,830,166 - 14,830,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371814,830,165 - 14,830,241 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera2129,368 - 29,444 (-)NCBI
Cytogenetic Map18p11.21NCBI
HuRef21424,855 - 424,931 (-)NCBIHuRef
CHM1_11814,829,216 - 14,829,292 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21199797   PMID:31926946  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:22660
Count of gene targets:10759
Count of transcripts:20560
Interacting mature miRNAs:hsa-miR-3156-3p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 2 1 3 5 1 2 1 4
Below cutoff 1 2 1 3 1 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000581101
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1814,830,166 - 14,830,242 (+)Ensembl
RefSeq Acc Id: NR_036153
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381814,830,166 - 14,830,242 (+)NCBI
GRCh371814,830,165 - 14,830,241 (+)RGD
Celera1829,368 - 29,444 (-)RGD
HuRef18424,855 - 424,931 (-)RGD
CHM1_11814,829,216 - 14,829,292 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 18p11.32-q23(chr18:149089-80234391)x3 copy number gain See cases [RCV000134110] Chr18:149089..80234391 [GRCh38]
Chr18:149089..77992274 [GRCh37]
Chr18:139089..76093265 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:118760-80254946)x3 copy number gain See cases [RCV000138656] Chr18:118760..80254946 [GRCh38]
Chr18:118760..78012829 [GRCh37]
Chr18:108760..76113817 [NCBI36]
Chr18:18p11.32-q23
pathogenic|conflicting data from submitters
GRCh38/hg38 18p11.32-q23(chr18:149089-80254936)x3 copy number gain See cases [RCV000139397] Chr18:149089..80254936 [GRCh38]
Chr18:149089..78012819 [GRCh37]
Chr18:139089..76113807 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.21(chr18:14418523-15165373)x3 copy number gain See cases [RCV000139060] Chr18:14418523..15165373 [GRCh38]
Chr18:14418522..15165372 [GRCh37]
Chr18:14408522..15155372 [NCBI36]
Chr18:18p11.21
likely benign
GRCh38/hg38 18p11.32-11.21(chr18:136226-15175006) copy number gain See cases [RCV000140442] Chr18:136226..15175006 [GRCh38]
Chr18:136226..15175005 [GRCh37]
Chr18:126226..15165005 [NCBI36]
Chr18:18p11.32-11.21
pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:118760-15024003)x1 copy number loss See cases [RCV000141086] Chr18:118760..15024003 [GRCh38]
Chr18:118760..15024002 [GRCh37]
Chr18:108760..15014002 [NCBI36]
Chr18:18p11.32-11.21
pathogenic
GRCh38/hg38 18p11.21(chr18:14807930-14837136)x3 copy number gain See cases [RCV000141091] Chr18:14807930..14837136 [GRCh38]
Chr18:14807929..14837135 [GRCh37]
Chr18:14797929..14827135 [NCBI36]
Chr18:18p11.21
benign
GRCh38/hg38 18p11.21(chr18:14807930-14850047)x3 copy number gain See cases [RCV000141092] Chr18:14807930..14850047 [GRCh38]
Chr18:14807929..14850046 [GRCh37]
Chr18:14797929..14840046 [NCBI36]
Chr18:18p11.21
benign
GRCh38/hg38 18p11.21(chr18:14695719-15215783)x3 copy number gain See cases [RCV000141095] Chr18:14695719..15215783 [GRCh38]
Chr18:14695718..15215782 [GRCh37]
Chr18:14685718..15205782 [NCBI36]
Chr18:18p11.21
benign
GRCh38/hg38 18p11.21(chr18:14695719-15165152)x3 copy number gain See cases [RCV000141097] Chr18:14695719..15165152 [GRCh38]
Chr18:14695718..15165151 [GRCh37]
Chr18:14685718..15155151 [NCBI36]
Chr18:18p11.21
benign
GRCh38/hg38 18p11.32-11.21(chr18:48782-14978076)x1 copy number loss See cases [RCV000141627] Chr18:48782..14978076 [GRCh38]
Chr18:48782..14978075 [GRCh37]
Chr18:38782..14968075 [NCBI36]
Chr18:18p11.32-11.21
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:136227-80256240)x3 copy number gain See cases [RCV000142244] Chr18:136227..80256240 [GRCh38]
Chr18:136227..78014123 [GRCh37]
Chr18:126227..76115097 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.22-q11.2(chr18:8779843-24685379)x3 copy number gain See cases [RCV000143075] Chr18:8779843..24685379 [GRCh38]
Chr18:8779841..22265343 [GRCh37]
Chr18:8769841..20519341 [NCBI36]
Chr18:18p11.22-q11.2
pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:136226-15198991)x4 copy number gain See cases [RCV000143434] Chr18:136226..15198991 [GRCh38]
Chr18:136226..15198990 [GRCh37]
Chr18:126226..15188990 [NCBI36]
Chr18:18p11.32-11.21
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:136226-80256240)x3 copy number gain See cases [RCV000143218] Chr18:136226..80256240 [GRCh38]
Chr18:136226..78014123 [GRCh37]
Chr18:126226..76115097 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80252149)x3 copy number gain See cases [RCV000148072] Chr18:148963..80252149 [GRCh38]
Chr18:148963..78010032 [GRCh37]
Chr18:138963..76111023 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.21-q11.2(chr18:13340112-23409879) copy number gain See cases [RCV000143455] Chr18:13340112..23409879 [GRCh38]
Chr18:13340111..20989843 [GRCh37]
Chr18:13330111..19243841 [NCBI36]
Chr18:18p11.21-q11.2
pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:10001-15380684)x3 copy number gain See cases [RCV000052499] Chr18:10001..15380684 [GRCh38]
Chr18:10001..15380683 [GRCh37]
Chr18:1..15370683 [NCBI36]
Chr18:18p11.32-11.21
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:53345-80209986)x3 copy number gain See cases [RCV000052501] Chr18:53345..80209986 [GRCh38]
Chr18:53345..77967869 [GRCh37]
Chr18:43345..76068860 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.32-q11.1(chr18:53345-20948503)x3 copy number gain See cases [RCV000052504] Chr18:53345..20948503 [GRCh38]
Chr18:53345..18528464 [GRCh37]
Chr18:43345..16782462 [NCBI36]
Chr18:18p11.32-q11.1
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148763-80252290)x3 copy number gain See cases [RCV000052507] Chr18:148763..80252290 [GRCh38]
Chr18:148763..78010173 [GRCh37]
Chr18:138763..76111164 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.32-q11.1(chr18:148963-21040153)x3 copy number gain See cases [RCV000052513] Chr18:148963..21040153 [GRCh38]
Chr18:148963..18620114 [GRCh37]
Chr18:138963..16874112 [NCBI36]
Chr18:18p11.32-q11.1
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80244381)x3 copy number gain See cases [RCV000052514] Chr18:148963..80244381 [GRCh38]
Chr18:148963..78002264 [GRCh37]
Chr18:138963..76103255 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:1919684-15325188)x3 copy number gain See cases [RCV000052535] Chr18:1919684..15325188 [GRCh38]
Chr18:1919685..15325187 [GRCh37]
Chr18:1909685..15315187 [NCBI36]
Chr18:18p11.32-11.21
pathogenic
GRCh38/hg38 18p11.32-11.21(chr18:131700-15121055)x1 copy number loss See cases [RCV000053458] Chr18:131700..15121055 [GRCh38]
Chr18:131700..15121054 [GRCh37]
Chr18:121700..15111054 [NCBI36]
Chr18:18p11.32-11.21
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80252149)x3 copy number gain See cases [RCV000051048] Chr18:148963..80252149 [GRCh38]
Chr18:148963..78010032 [GRCh37]
Chr18:138963..76111023 [NCBI36]
Chr18:18p11.32-q23
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3156-2 COSMIC
Ensembl Genes ENSG00000265499 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000581101 ENTREZGENE
GTEx ENSG00000265499 GTEx
HGNC ID HGNC:38213 ENTREZGENE
Human Proteome Map MIR3156-2 Human Proteome Map
miRBase MI0014230 ENTREZGENE
NCBI Gene 100422907 ENTREZGENE
PharmGKB PA165429050 PharmGKB
RNAcentral URS0000064063 RNACentral
  URS000075D48C RNACentral
  URS000075D876 RNACentral