Tmem95 (transmembrane protein 95) - Rat Genome Database

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Gene: Tmem95 (transmembrane protein 95) Mus musculus
Analyze
Symbol: Tmem95
Name: transmembrane protein 95
RGD ID: 2306601
MGI Page MGI
Description: Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Located in acrosomal membrane. Orthologous to human TMEM95 (transmembrane protein 95).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 432576; sperm-egg fusion protein TMEM95
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,766,880 - 69,768,997 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,766,883 - 69,768,879 (-)EnsemblGRCm39 Ensembl
GRCm381169,876,054 - 69,878,171 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,876,057 - 69,878,053 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,690,186 - 69,691,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,690,186 - 69,691,607 (-)NCBIMGSCv36mm8
Celera1177,424,239 - 77,425,660 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14610273   PMID:19468303   PMID:21267068   PMID:21873635   PMID:24391514   PMID:32393636   PMID:32484434   PMID:34982145   PMID:35096839  


Genomics

Comparative Map Data
Tmem95
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,766,880 - 69,768,997 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,766,883 - 69,768,879 (-)EnsemblGRCm39 Ensembl
GRCm381169,876,054 - 69,878,171 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,876,057 - 69,878,053 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,690,186 - 69,691,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,690,186 - 69,691,607 (-)NCBIMGSCv36mm8
Celera1177,424,239 - 77,425,660 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.91NCBI
TMEM95
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,355,156 - 7,357,219 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,355,123 - 7,357,219 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,258,475 - 7,260,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,199,221 - 7,201,262 (+)NCBINCBI36Build 36hg18NCBI36
Celera177,284,442 - 7,286,483 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,152,556 - 7,154,597 (+)NCBIHuRef
CHM1_1177,267,272 - 7,269,313 (+)NCBICHM1_1
T2T-CHM13v2.0177,259,147 - 7,261,210 (+)NCBIT2T-CHM13v2.0
Tmem95
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,098,518 - 55,100,463 (-)NCBIGRCr8
mRatBN7.21054,599,799 - 54,601,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,599,800 - 54,601,790 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,262,256 - 59,264,203 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,750,826 - 58,752,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010002074.112,432 - 14,388 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,486,778 - 56,488,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,487,417 - 56,488,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,231,897 - 56,233,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,720,626 - 56,721,932 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1053,753,809 - 53,755,754 (-)NCBICelera
Cytogenetic Map10q24NCBI
Tmem95
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,562,723 - 9,564,818 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,562,723 - 9,564,818 (-)NCBIChiLan1.0ChiLan1.0
TMEM95
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,952,039 - 14,955,464 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,917,864 - 16,921,299 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,389,244 - 7,391,773 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,375,450 - 7,376,962 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,375,571 - 7,377,086 (+)Ensemblpanpan1.1panPan2
TMEM95
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,309,025 - 32,311,010 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,309,129 - 32,310,965 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,446,984 - 32,448,971 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,414,329 - 32,416,317 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,414,436 - 32,416,272 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,379,792 - 32,381,780 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,338,533 - 32,340,519 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,515,577 - 32,517,564 (+)NCBIUU_Cfam_GSD_1.0
Tmem95
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,173,351 - 47,175,510 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595647,735 - 649,152 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595647,735 - 649,152 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM95
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,701,052 - 52,703,216 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,701,119 - 52,704,121 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,919,875 - 54,922,001 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM95
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,733,315 - 6,735,500 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,733,479 - 6,734,906 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,676,228 - 14,677,671 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem95
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,976,052 - 9,977,825 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,975,903 - 9,978,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem95
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:163
Interacting mature miRNAs:172
Transcripts:ENSMUST00000178597
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000178597   ⟹   ENSMUSP00000137492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,766,883 - 69,768,879 (-)Ensembl
GRCm38.p6 Ensembl1169,876,057 - 69,878,053 (-)Ensembl
RefSeq Acc Id: NM_001195710   ⟹   NP_001182639
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,766,880 - 69,768,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006531882   ⟹   XP_006531945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,767,449 - 69,768,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156170   ⟹   XP_036012063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,767,447 - 69,768,997 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182639 (Get FASTA)   NCBI Sequence Viewer  
  XP_006531945 (Get FASTA)   NCBI Sequence Viewer  
  XP_036012063 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000137492
  ENSMUSP00000137492.2
GenBank Protein P0DJF3 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSMUSP00000137492   ⟸   ENSMUST00000178597
RefSeq Acc Id: NP_001182639   ⟸   NM_001195710
- Peptide Label: precursor
- UniProtKB: P0DJF3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_036012063   ⟸   XM_036156170
- Peptide Label: isoform X2
RefSeq Acc Id: XP_006531945   ⟸   XM_006531882
- Peptide Label: isoform X1
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DJF3-F1-model_v2 AlphaFold P0DJF3 1-176 view protein structure

Promoters
RGD ID:6822345
Promoter ID:MM_KWN:8133
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_153143,   XM_484042_TMEM95
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,693,201 - 69,694,657 (-)MPROMDB
RGD ID:8675240
Promoter ID:EPDNEW_M15649
Type:initiation region
Name:Tmem95_1
Description:Mus musculus transmembrane protein 95 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,878,035 - 69,878,095EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3779488 AgrOrtholog
Ensembl Genes ENSMUSG00000094845 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000178597 ENTREZGENE
  ENSMUST00000178597.3 UniProtKB/Swiss-Prot
InterPro TMEM95 UniProtKB/Swiss-Prot
KEGG Report mmu:100503361 UniProtKB/Swiss-Prot
MGD MGI:3779488 ENTREZGENE
NCBI Gene Tmem95 ENTREZGENE
PANTHER PTHR38808 UniProtKB/Swiss-Prot
  SPERM-EGG FUSION PROTEIN TMEM95 UniProtKB/Swiss-Prot
Pfam TMEM95 UniProtKB/Swiss-Prot
PhenoGen Tmem95 PhenoGen
UniProt P0DJF3 ENTREZGENE, UniProtKB/Swiss-Prot