Pafah1b2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2) - Rat Genome Database

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Gene: Pafah1b2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2) Heterocephalus glaber
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Symbol: Pafah1b2
Name: platelet activating factor acetylhydrolase 1b catalytic subunit 2
RGD ID: 18933688
Description: ENCODES a protein that exhibits 1-alkyl-2-acetylglycerophosphocholine esterase activity (ortholog); identical protein binding (ortholog); platelet-activating factor acetyltransferase activity (ortholog); INVOLVED IN positive regulation of macroautophagy (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; ASSOCIATED WITH CD3epsilon deficiency (ortholog); chromosome 11 partial duplication syndrome (ortholog); Dwarfism (ortholog); FOUND IN 1-alkyl-2-acetylglycerophosphocholine esterase complex (ortholog); cytosol (ortholog); fibrillar center (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Platelet-activating factor acetylhydrolase IB subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478412,583,430 - 12,619,816 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625  


Genomics

Comparative Map Data
Pafah1b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478412,583,430 - 12,619,816 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PAFAH1B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,144,287 - 117,178,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11117,144,284 - 117,176,894 (+)EnsemblGRCh38hg38GRCh38
GRCh3711117,015,003 - 117,048,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,520,250 - 116,544,024 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411116,520,249 - 116,544,024NCBI
Celera11114,172,757 - 114,205,230 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,947,322 - 112,980,405 (+)NCBIHuRef
CHM1_111116,899,903 - 116,932,472 (+)NCBICHM1_1
T2T-CHM13v2.011117,159,595 - 117,193,468 (+)NCBIT2T-CHM13v2.0
Pafah1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,876,609 - 45,923,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,874,157 - 45,923,988 (-)EnsemblGRCm39 Ensembl
GRCm38945,965,311 - 46,012,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,962,859 - 46,012,690 (-)EnsemblGRCm38mm10GRCm38
MGSCv37945,773,394 - 45,792,954 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,716,306 - 45,735,866 (-)NCBIMGSCv36mm8
Celera943,249,530 - 43,269,004 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
Pafah1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,156,778 - 55,208,800 (-)NCBIGRCr8
mRatBN7.2846,260,069 - 46,312,073 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,261,064 - 46,279,833 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx851,761,686 - 51,780,128 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,040,454 - 50,058,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,904,724 - 47,923,167 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,256,969 - 50,310,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,259,248 - 50,277,797 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,883,712 - 48,934,692 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,938,556 - 48,957,109 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1848,947,322 - 48,965,875 (-)NCBI
Celera845,843,851 - 45,862,380 (-)NCBICelera
Cytogenetic Map8q22NCBI
Pafah1b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,474,199 - 18,494,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,471,621 - 18,494,082 (+)NCBIChiLan1.0ChiLan1.0
PAFAH1B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,844,005 - 117,870,689 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,950,015 - 118,976,715 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,978,368 - 112,005,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,911,803 - 115,944,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,911,803 - 115,944,351 (+)Ensemblpanpan1.1panPan2
PAFAH1B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.0516,361,852 - 16,392,824 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,358,906 - 16,392,810 (-)EnsemblROS_Cfam_1.0 Ensembl
Pafah1b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,469,237 - 99,496,440 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,390,513 - 2,414,882 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,390,904 - 2,417,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAFAH1B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,513,461 - 44,536,432 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,513,114 - 44,534,312 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,590,686 - 49,603,905 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAFAH1B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,514,443 - 108,542,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,514,172 - 108,544,049 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,512,255 - 17,540,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_004856652   ⟹   XP_004856709
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478412,583,442 - 12,619,816 (+)NCBI
RefSeq Acc Id: XM_004856653   ⟹   XP_004856710
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478412,583,430 - 12,619,816 (+)NCBI
RefSeq Acc Id: XM_013076665   ⟹   XP_012932119
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478412,589,404 - 12,619,816 (+)NCBI
RefSeq Acc Id: XM_021237736   ⟹   XP_021093395
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478412,583,442 - 12,619,816 (+)NCBI
RefSeq Acc Id: XM_021237737   ⟹   XP_021093396
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478412,583,441 - 12,619,816 (+)NCBI
RefSeq Acc Id: XP_004856710   ⟸   XM_004856653
- Peptide Label: isoform X3
- UniProtKB: G5BH11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093396   ⟸   XM_021237737
- Peptide Label: isoform X3
- UniProtKB: G5BH11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093395   ⟸   XM_021237736
- Peptide Label: isoform X2
- UniProtKB: A0AAX6PPS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004856709   ⟸   XM_004856652
- Peptide Label: isoform X2
- UniProtKB: A0AAX6PPS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932119   ⟸   XM_013076665
- Peptide Label: isoform X1
- UniProtKB: A0AAX6R4E9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019038 ENTREZGENE
Ensembl Transcript ENSHGLT00000027006 ENTREZGENE
  ENSHGLT00000027007 ENTREZGENE
Gene3D-CATH 3.40.50.1110 UniProtKB/TrEMBL
InterPro SGNH_hydro UniProtKB/TrEMBL
  SGNH_hydro_sf UniProtKB/TrEMBL
NCBI Gene Pafah1b2 ENTREZGENE
PANTHER PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE UniProtKB/TrEMBL
  PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA2 UniProtKB/TrEMBL
Pfam Lipase_GDSL_2 UniProtKB/TrEMBL
Superfamily-SCOP SGNH hydrolase UniProtKB/TrEMBL
UniProt A0AAX6PPS9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R4E9 ENTREZGENE, UniProtKB/TrEMBL
  G5BH11 ENTREZGENE, UniProtKB/TrEMBL