Dcaf12 (DDB1 and CUL4 associated factor 12) - Rat Genome Database

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Gene: Dcaf12 (DDB1 and CUL4 associated factor 12) Heterocephalus glaber
Analyze
Symbol: Dcaf12
Name: DDB1 and CUL4 associated factor 12
RGD ID: 18930511
Description: ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN regulation of autophagy (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); distal arthrogryposis type 1A (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DDB1- and CUL4-associated factor 12; WD repeat-containing protein 40A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473638,489,466 - 38,527,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473638,488,120 - 38,528,500 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dcaf12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473638,489,466 - 38,527,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473638,488,120 - 38,528,500 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DCAF12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,086,387 - 34,126,698 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,086,387 - 34,127,399 (-)EnsemblGRCh38hg38GRCh38
GRCh37934,086,385 - 34,126,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,076,386 - 34,116,736 (-)NCBINCBI36Build 36hg18NCBI36
Build 34934,076,385 - 34,116,736NCBI
Celera934,018,151 - 34,058,841 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,043,628 - 34,084,726 (-)NCBIHuRef
CHM1_1934,086,163 - 34,126,582 (-)NCBICHM1_1
T2T-CHM13v2.0934,104,956 - 34,145,564 (-)NCBIT2T-CHM13v2.0
Dcaf12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,291,300 - 41,316,749 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,291,300 - 41,314,889 (-)EnsemblGRCm39 Ensembl
GRCm38441,291,300 - 41,316,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,291,300 - 41,314,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37441,238,333 - 41,261,934 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,479,975 - 41,503,487 (-)NCBIMGSCv36mm8
Celera440,952,551 - 40,976,145 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map421.32NCBI
Dcaf12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,256,353 - 61,278,155 (-)NCBIGRCr8
mRatBN7.2556,460,418 - 56,482,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,461,006 - 56,482,456 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0557,666,781 - 57,685,360 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,667,376 - 57,683,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,188,140 - 62,206,747 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera555,059,113 - 55,079,083 (-)NCBICelera
Cytogenetic Map5q22NCBI
Dcaf12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,943,477 - 1,974,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,943,477 - 1,974,938 (+)NCBIChiLan1.0ChiLan1.0
DCAF12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,475,446 - 90,516,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1990,481,387 - 90,522,573 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0933,923,900 - 33,964,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1934,733,845 - 34,776,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl934,733,845 - 34,775,624 (-)Ensemblpanpan1.1panPan2
DCAF12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,843,818 - 50,878,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,845,773 - 50,878,838 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,473,430 - 49,508,400 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01151,785,626 - 51,820,430 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,785,626 - 51,820,424 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,448,700 - 50,483,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,316,388 - 50,351,073 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,081,583 - 51,116,364 (-)NCBIUU_Cfam_GSD_1.0
Dcaf12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,691,052 - 165,726,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,238,602 - 2,273,349 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,239,972 - 2,272,885 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCAF12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,674,045 - 32,714,940 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,673,982 - 32,714,940 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,861,451 - 36,902,281 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCAF12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11246,468,750 - 46,504,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1246,468,714 - 46,504,557 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603843,485,525 - 43,510,111 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000011187   ⟹   ENSHGLP00000011063
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473638,489,466 - 38,527,706 (-)Ensembl
RefSeq Acc Id: XM_004838411   ⟹   XP_004838468
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473638,488,120 - 38,527,699 (-)NCBI
RefSeq Acc Id: XM_021252971   ⟹   XP_021108630
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473638,488,120 - 38,528,500 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004838468 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108630 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02661 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011063
GenBank Protein JAO02749 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021108630   ⟸   XM_021252971
- Peptide Label: isoform X2
- UniProtKB: A0AAX6SHL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004838468   ⟸   XM_004838411
- Peptide Label: isoform X1
- UniProtKB: G5B050 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011063   ⟸   ENSHGLT00000011187


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007936 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000011187 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro DCAF12 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101697412 UniProtKB/TrEMBL
NCBI Gene Dcaf12 ENTREZGENE
PANTHER DDB1- AND CUL4-ASSOCIATED FACTOR 12 UniProtKB/TrEMBL
  DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0AAX6SHL7 ENTREZGENE, UniProtKB/TrEMBL
  G5B050 ENTREZGENE, UniProtKB/TrEMBL