Dcaf12 (DDB1 and CUL4 associated factor 12) - Rat Genome Database

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Gene: Dcaf12 (DDB1 and CUL4 associated factor 12) Heterocephalus glaber
Analyze
Symbol: Dcaf12
Name: DDB1 and CUL4 associated factor 12
RGD ID: 18930511
Description: ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN regulation of autophagy (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); distal arthrogryposis type 1A (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DDB1- and CUL4-associated factor 12; WD repeat-containing protein 40A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473638,489,466 - 38,527,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473638,488,120 - 38,528,500 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dcaf12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473638,489,466 - 38,527,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473638,488,120 - 38,528,500 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DCAF12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,086,387 - 34,126,698 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,086,387 - 34,127,399 (-)EnsemblGRCh38hg38GRCh38
GRCh37934,086,385 - 34,126,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,076,386 - 34,116,736 (-)NCBINCBI36Build 36hg18NCBI36
Build 34934,076,385 - 34,116,736NCBI
Celera934,018,151 - 34,058,841 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,043,628 - 34,084,726 (-)NCBIHuRef
CHM1_1934,086,163 - 34,126,582 (-)NCBICHM1_1
T2T-CHM13v2.0934,104,956 - 34,145,564 (-)NCBIT2T-CHM13v2.0
Dcaf12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,291,300 - 41,316,749 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,291,300 - 41,314,889 (-)EnsemblGRCm39 Ensembl
GRCm38441,291,300 - 41,316,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,291,300 - 41,314,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37441,238,333 - 41,261,934 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,479,975 - 41,503,487 (-)NCBIMGSCv36mm8
Celera440,952,551 - 40,976,145 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map421.32NCBI
Dcaf12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,256,353 - 61,278,155 (-)NCBIGRCr8
mRatBN7.2556,460,418 - 56,482,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,461,006 - 56,482,456 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0557,666,781 - 57,685,360 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,667,376 - 57,683,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,188,140 - 62,206,747 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera555,059,113 - 55,079,083 (-)NCBICelera
Cytogenetic Map5q22NCBI
Dcaf12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,943,477 - 1,974,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,943,477 - 1,974,938 (+)NCBIChiLan1.0ChiLan1.0
DCAF12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,475,446 - 90,516,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1990,481,387 - 90,522,573 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0933,923,900 - 33,964,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1934,733,845 - 34,776,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl934,733,845 - 34,775,624 (-)Ensemblpanpan1.1panPan2
DCAF12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,843,818 - 50,878,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,845,773 - 50,878,838 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,473,430 - 49,508,400 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01151,785,626 - 51,820,430 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,785,626 - 51,820,424 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,448,700 - 50,483,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,316,388 - 50,351,073 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,081,583 - 51,116,364 (-)NCBIUU_Cfam_GSD_1.0
Dcaf12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,691,052 - 165,726,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,238,602 - 2,273,349 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,239,972 - 2,272,885 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCAF12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,674,045 - 32,714,940 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,673,982 - 32,714,940 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,861,451 - 36,902,281 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCAF12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11246,468,750 - 46,504,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1246,468,714 - 46,504,557 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603843,485,525 - 43,510,111 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000011187   ⟹   ENSHGLP00000011063
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473638,489,466 - 38,527,706 (-)Ensembl
RefSeq Acc Id: XM_004838411   ⟹   XP_004838468
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473638,488,120 - 38,527,699 (-)NCBI
RefSeq Acc Id: XM_021252971   ⟹   XP_021108630
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473638,488,120 - 38,528,500 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004838468 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108630 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02661 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011063
  ENSHGLP00100018534
GenBank Protein JAO02749 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021108630   ⟸   XM_021252971
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004838468   ⟸   XM_004838411
- Peptide Label: isoform X1
- UniProtKB: G5B050 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000011063   ⟸   ENSHGLT00000011187


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007936 Ensembl, ENTREZGENE
  ENSHGLG00100013662 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000011187 ENTREZGENE
  ENSHGLT00100018728 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101697412 UniProtKB/TrEMBL
NCBI Gene Dcaf12 ENTREZGENE
PANTHER DDB1- AND CUL4-ASSOCIATED FACTOR 12 UniProtKB/TrEMBL
  DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt G5B050 ENTREZGENE, UniProtKB/TrEMBL