Cubn (cubilin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cubn (cubilin) Heterocephalus glaber
Analyze
Symbol: Cubn
Name: cubilin
RGD ID: 18928733
Description: ENCODES a protein that exhibits cargo receptor activity (ortholog); hemoglobin binding (ortholog); identical protein binding (ortholog); INVOLVED IN cobalamin catabolic process (ortholog); cobalamin metabolic process (ortholog); cobalamin transport (ortholog); ASSOCIATED WITH amphetamine abuse (ortholog); autism spectrum disorder (ortholog); Chronic Benign Proteinuria (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); brush border (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479610,728,983 - 10,988,361 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479610,728,853 - 10,987,292 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Cubn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479610,728,983 - 10,988,361 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479610,728,853 - 10,987,292 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CUBN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381016,823,966 - 17,129,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1016,823,966 - 17,129,811 (-)EnsemblGRCh38hg38GRCh38
GRCh371016,865,965 - 17,171,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361016,905,971 - 17,211,822 (-)NCBINCBI36Build 36hg18NCBI36
Build 341016,906,543 - 17,211,796NCBI
Celera1016,799,178 - 17,105,066 (-)NCBICelera
Cytogenetic Map10p13NCBI
HuRef1016,779,758 - 17,084,998 (-)NCBIHuRef
CHM1_11016,866,152 - 17,171,970 (-)NCBICHM1_1
T2T-CHM13v2.01016,842,423 - 17,148,343 (-)NCBIT2T-CHM13v2.0
Cubn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39213,281,149 - 13,496,687 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl213,281,149 - 13,496,624 (-)EnsemblGRCm39 Ensembl
GRCm38213,276,338 - 13,491,876 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl213,276,338 - 13,491,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv37213,197,965 - 13,413,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36213,194,189 - 13,409,729 (-)NCBIMGSCv36mm8
Celera213,186,219 - 13,402,130 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map29.86NCBI
Cubn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81781,293,619 - 81,501,694 (-)NCBIGRCr8
mRatBN7.21776,385,046 - 76,593,133 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1776,385,060 - 76,593,231 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1779,857,681 - 80,065,673 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01783,693,064 - 83,901,073 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01777,740,972 - 77,948,974 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01780,584,921 - 80,807,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1780,584,878 - 80,807,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01782,205,509 - 82,425,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41787,545,893 - 87,772,079 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11787,556,725 - 87,782,912 (-)NCBI
Celera1775,753,959 - 75,962,017 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
Cubn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542910,788,959 - 11,038,845 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542910,789,674 - 11,038,297 (+)NCBIChiLan1.0ChiLan1.0
CUBN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2829,666,975 - 29,981,918 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11029,672,298 - 29,977,993 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01017,141,464 - 17,446,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11017,415,551 - 17,719,126 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1017,415,551 - 17,719,129 (-)Ensemblpanpan1.1panPan2
CUBN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1219,784,125 - 20,041,840 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl219,784,198 - 20,041,839 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,887,230 - 17,151,382 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0220,075,720 - 20,333,544 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl220,075,720 - 20,333,543 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1217,278,052 - 17,541,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0218,116,485 - 18,374,283 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0218,734,135 - 18,999,935 (+)NCBIUU_Cfam_GSD_1.0
Cubn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934417,550,256 - 17,808,034 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652010,140,784 - 10,409,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493652010,140,784 - 10,410,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUBN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1043,102,946 - 43,414,758 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11043,102,931 - 43,414,692 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21047,746,354 - 48,023,009 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUBN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1916,774,644 - 17,079,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl916,774,757 - 17,079,681 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605122,409,233 - 22,718,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000006132   ⟹   ENSHGLP00000006057
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479610,728,983 - 10,988,361 (+)Ensembl
RefSeq Acc Id: XM_004859974   ⟹   XP_004860031
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479610,728,853 - 10,987,292 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004860031 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006057
GenBank Protein JAO01616 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004860031   ⟸   XM_004859974
- UniProtKB: A0A0P6JBC8 (UniProtKB/TrEMBL),   G5BFE6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000006057   ⟸   ENSHGLT00000006132


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004428 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006132 ENTREZGENE
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  Cubilin_domain UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  EGF_dom UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101720941 UniProtKB/TrEMBL
NCBI Gene Cubn ENTREZGENE
PANTHER C-TYPE LECTIN UniProtKB/TrEMBL
  C-TYPE LECTIN-RELATED UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49854 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0P6JBC8 ENTREZGENE, UniProtKB/TrEMBL
  G5BFE6 ENTREZGENE, UniProtKB/TrEMBL