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Gene: Dennd11 (DENN domain containing 11) Heterocephalus glaber

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Symbol:

Dennd11

Name:

DENN domain containing 11

RGD ID:

18928178

Description:

ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); ASSOCIATED WITH RASopathy (ortholog); Sengers syndrome (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Kiaa1147; Protein LCHN

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	21,673,266 - 21,712,949 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624765	21,663,672 - 21,712,058 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd11	Naked Mole-Rat	RASopathy		ISO	RGD:1603618	8554872	ClinVar Annotator: match by term: RASopathy	ClinVar	PMID:12414817\|PMID:16611712\|PMID:28492532
Dennd11	Naked Mole-Rat	Sengers syndrome		ISO	RGD:1603618	8554872	ClinVar Annotator: match by term: Sengers syndrome	ClinVar	PMID:22284826\|PMID:28492532

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd11	Naked Mole-Rat	cytoplasm	located_in	IEA	PANTHER:PTN002025435	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd11	Naked Mole-Rat	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB-KW:KW-0344	150520179		UniProt	GO_REF:0000043

PMID:21993625	PMID:30032202

Dennd11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	21,673,266 - 21,712,949 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624765	21,663,672 - 21,712,058 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

DENND11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	141,656,728 - 141,702,166 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	141,656,728 - 141,702,166 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	141,356,528 - 141,401,966 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	141,002,997 - 141,048,422 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	136,078,159 - 136,123,586 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI
HuRef	7	135,653,910 - 135,698,743 (-)	NCBI		HuRef
CHM1_1	7	141,290,834 - 141,336,265 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	142,972,579 - 143,017,998 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	140,694,236 - 140,739,666 (-)	NCBI

Dennd11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	40,378,309 - 40,413,069 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	40,378,309 - 40,413,069 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	40,401,375 - 40,436,135 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	40,401,375 - 40,436,135 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	40,357,497 - 40,386,132 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	40,337,105 - 40,365,740 (-)	NCBI		MGSCv36	mm8
Celera	6	40,394,757 - 40,423,431 (-)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI
cM Map	6	18.82	NCBI

Dennd11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	70,163,869 - 70,232,731 (-)	NCBI		GRCr8
mRatBN7.2	4	69,197,161 - 69,266,013 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	69,198,068 - 69,228,821 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	74,130,661 - 74,157,083 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	70,051,801 - 70,078,231 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	68,463,273 - 68,489,696 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	68,569,308 - 68,597,626 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	68,569,691 - 68,597,586 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	133,354,586 - 133,383,909 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	67,962,305 - 67,988,706 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	64,205,409 - 64,231,808 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI

Dennd11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955494	1,871,284 - 1,916,443 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955494	1,868,793 - 1,921,919 (+)	NCBI	ChiLan1.0	ChiLan1.0

DENND11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	178,440,083 - 178,485,216 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	30,450,338 - 30,495,458 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	133,578,537 - 133,628,133 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	146,048,756 - 146,082,665 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

DENND11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	7,531,025 - 7,559,156 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	7,531,078 - 7,554,543 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	8,356,983 - 8,403,668 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	7,433,958 - 7,480,398 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	7,433,817 - 7,479,738 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	7,387,220 - 7,433,622 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	7,229,802 - 7,275,963 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	7,297,580 - 7,344,213 (+)	NCBI		UU_Cfam_GSD_1.0

Dennd11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	13,645,548 - 13,687,589 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936592	5,537,657 - 5,560,180 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936592	5,532,214 - 5,574,255 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DENND11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	8,205,600 - 8,261,702 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	8,205,711 - 8,261,704 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	8,498,126 - 8,553,226 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DENND11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	110,349,151 - 110,450,460 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	110,412,647 - 110,450,209 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	7,082,301 - 7,170,665 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_004851296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021263710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002397125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01046158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01046159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01046160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH168530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000014562 ⟹ ENSHGLP00000014417

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624765	21,673,266 - 21,712,949 (-)	Ensembl

Ensembl Acc Id:

ENSHGLT00000014563 ⟹ ENSHGLP00000014418

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624765	21,683,298 - 21,707,000 (-)	Ensembl

RefSeq Acc Id:

XM_004851296 ⟹ XP_004851353

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624765	21,667,853 - 21,712,058 (-)	NCBI

RefSeq Acc Id:

XM_021263710 ⟹ XP_021119369

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624765	21,663,672 - 21,712,058 (-)	NCBI

RefSeq Acc Id:

XR_002397125

Type:

NON-CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624765	21,667,853 - 21,712,043 (-)	NCBI


Protein RefSeqs	XP_004851353	(Get FASTA)	NCBI Sequence Viewer
	XP_021119369	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHB04439	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000014417

RefSeq Acc Id:	XP_021119369 ⟸ XM_021263710
- Peptide Label:	isoform X2
- UniProtKB:	A0AAX6TFZ8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_004851353 ⟸ XM_004851296
- Peptide Label:	isoform X1
- UniProtKB:	G5B578 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000014417 ⟸ ENSHGLT00000014562

Ensembl Acc Id:

ENSHGLP00000014418 ⟸ ENSHGLT00000014563

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000010322	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSHGLT00000014562	ENTREZGENE, UniProtKB/TrEMBL
InterPro	DENND11/AVL9_GEFs	UniProtKB/TrEMBL
	LCHN/Anr2	UniProtKB/TrEMBL
	Tripartite_DENN	UniProtKB/TrEMBL
KEGG Report	hgl:101706379	UniProtKB/TrEMBL
NCBI Gene	Dennd11	ENTREZGENE
PANTHER	DENN DOMAIN-CONTAINING PROTEIN 11	UniProtKB/TrEMBL
	LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED	UniProtKB/TrEMBL
Pfam	DENND11	UniProtKB/TrEMBL
PROSITE	DENN	UniProtKB/TrEMBL
UniProt	A0AAX6TFZ8	ENTREZGENE, UniProtKB/TrEMBL
	G5B578	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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