Ttbk1 (tau tubulin kinase 1) - Rat Genome Database

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Gene: Ttbk1 (tau tubulin kinase 1) Heterocephalus glaber
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Symbol: Ttbk1
Name: tau tubulin kinase 1
RGD ID: 18927906
Description: ENCODES a protein that exhibits protein serine kinase activity (ortholog); protein tyrosine kinase activity (ortholog); tau protein binding (ortholog); INVOLVED IN learning or memory (ortholog); negative regulation of gene expression (ortholog); peptidyl-serine phosphorylation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Childhood Schizophrenia (ortholog); infantile Refsum disease (ortholog); FOUND IN cytosol (ortholog); neuronal cell body (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Tau-tubulin kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,290,613 - 16,320,070 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,288,172 - 16,322,794 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ttbk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,290,613 - 16,320,070 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,288,172 - 16,322,794 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TTBK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,243,481 - 43,288,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,243,481 - 43,288,258 (+)EnsemblGRCh38hg38GRCh38
GRCh37643,211,219 - 43,255,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,319,200 - 43,363,975 (+)NCBINCBI36Build 36hg18NCBI36
Build 34643,319,199 - 43,363,975NCBI
Celera644,763,431 - 44,808,208 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,931,340 - 42,973,614 (+)NCBIHuRef
CHM1_1643,214,168 - 43,258,942 (+)NCBICHM1_1
T2T-CHM13v2.0643,072,270 - 43,117,062 (+)NCBIT2T-CHM13v2.0
Ttbk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,751,577 - 46,798,596 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,753,374 - 46,798,601 (-)EnsemblGRCm39 Ensembl
GRCm381746,442,448 - 46,487,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,442,448 - 46,487,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,579,397 - 46,624,624 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,905,637 - 45,907,556 (-)NCBIMGSCv36mm8
Celera1749,878,167 - 49,923,194 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Ttbk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,990,973 - 22,035,961 (+)NCBIGRCr8
mRatBN7.2914,493,166 - 14,538,372 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,493,389 - 14,535,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,080,333 - 23,117,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,143,428 - 28,180,645 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,443,713 - 26,480,742 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,862,305 - 16,899,399 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,862,248 - 16,902,199 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,761,885 - 15,798,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,881,464 - 9,920,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera912,244,422 - 12,281,152 (+)NCBICelera
Cytogenetic Map9q12NCBI
Ttbk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,165,414 - 9,197,612 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,161,880 - 9,195,098 (+)NCBIChiLan1.0ChiLan1.0
TTBK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,743,402 - 57,791,429 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,613,236 - 53,661,268 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,835,285 - 42,880,100 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1644,131,311 - 44,172,795 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,131,360 - 44,169,912 (+)Ensemblpanpan1.1panPan2
TTBK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,738,466 - 11,774,663 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,738,232 - 11,757,814 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,762,153 - 11,804,423 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,219,189 - 12,261,503 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,219,010 - 12,258,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,744,980 - 11,787,237 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,829,216 - 11,868,477 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,924,194 - 11,963,564 (+)NCBIUU_Cfam_GSD_1.0
Ttbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,234,441 - 47,275,246 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,689,305 - 16,725,708 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,686,513 - 16,725,750 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTBK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,276,126 - 38,319,485 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,276,466 - 38,319,486 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,776,644 - 43,819,849 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTBK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,865,747 - 28,911,978 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1728,868,627 - 28,908,097 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604443,303,527 - 43,349,009 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000027226   ⟹   ENSHGLP00000026987
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475416,290,613 - 16,320,070 (-)Ensembl
RefSeq Acc Id: XM_004846511   ⟹   XP_004846568
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,288,172 - 16,322,794 (-)NCBI
RefSeq Acc Id: XM_021259777   ⟹   XP_021115436
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475416,288,172 - 16,322,794 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004846568 (Get FASTA)   NCBI Sequence Viewer  
  XP_021115436 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB10865 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026987
RefSeq Acc Id: XP_004846568   ⟸   XM_004846511
- Peptide Label: isoform X2
- UniProtKB: A0AAX6P9M8 (UniProtKB/TrEMBL),   G5BNL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021115436   ⟸   XM_021259777
- Peptide Label: isoform X1
- UniProtKB: A0AAX6T225 (UniProtKB/TrEMBL),   G5BNL9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026987   ⟸   ENSHGLT00000027226


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019189 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027226 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CK1_Ser-Thr_kinase UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  TTBK1_STKc UniProtKB/TrEMBL
NCBI Gene Ttbk1 ENTREZGENE
PANTHER CASEIN KINASE-RELATED UniProtKB/TrEMBL
  TAU-TUBULIN KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt A0AAX6P9M8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6T225 ENTREZGENE, UniProtKB/TrEMBL
  G5BNL9 ENTREZGENE, UniProtKB/TrEMBL