Dennd6a (DENN domain containing 6A) - Rat Genome Database

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Gene: Dennd6a (DENN domain containing 6A) Heterocephalus glaber
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Symbol: Dennd6a
Name: DENN domain containing 6A
RGD ID: 18924903
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN positive regulation of cell-cell adhesion mediated by cadherin (ortholog); ASSOCIATED WITH amenorrhea (ortholog); Pyruvate Dehydrogenase E1-Beta Deficiency (ortholog); FOUND IN cytoplasm (ortholog); intracellular membrane-bounded organelle (ortholog); recycling endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein DENND6A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821376,525 - 446,583 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624821374,615 - 446,656 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Dennd6a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821376,525 - 446,583 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624821374,615 - 446,656 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DENND6A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38357,625,454 - 57,693,077 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl357,625,454 - 57,693,077 (-)EnsemblGRCh38hg38GRCh38
GRCh37357,611,181 - 57,678,804 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,586,224 - 57,653,844 (-)NCBINCBI36Build 36hg18NCBI36
Celera357,624,256 - 57,692,688 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef357,708,594 - 57,776,280 (-)NCBIHuRef
CHM1_1357,561,278 - 57,628,877 (-)NCBICHM1_1
T2T-CHM13v2.0357,665,829 - 57,733,445 (-)NCBIT2T-CHM13v2.0
Dennd6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,295,013 - 26,355,477 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,295,011 - 26,355,477 (+)EnsemblGRCm39 Ensembl
GRCm381426,573,858 - 26,634,322 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,573,856 - 26,634,322 (+)EnsemblGRCm38mm10GRCm38
MGSCv371427,399,036 - 27,451,586 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361425,412,745 - 25,461,593 (+)NCBIMGSCv36mm8
Celera1422,823,047 - 22,874,957 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Dennd6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8161,843,803 - 1,892,165 (+)NCBIGRCr8
mRatBN7.2161,837,019 - 1,885,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,837,059 - 1,885,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,843,688 - 1,892,050 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0162,989,384 - 3,037,744 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0161,850,139 - 1,898,501 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,278,701 - 2,327,062 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,278,701 - 2,327,062 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,252,208 - 2,289,395 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0162,297,248 - 2,302,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,896,071 - 1,944,337 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1161,876,717 - 1,944,327 (+)NCBI
Celera161,806,443 - 1,854,294 (+)NCBICelera
Cytogenetic Map16p16NCBI
Dennd6a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554307,327,602 - 7,397,670 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554307,327,602 - 7,396,961 (-)NCBIChiLan1.0ChiLan1.0
DENND6A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,593,496 - 57,665,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,598,266 - 57,668,504 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,558,551 - 57,627,298 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1358,978,866 - 59,046,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,978,866 - 59,046,737 (-)Ensemblpanpan1.1panPan2
DENND6A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,780,529 - 32,830,388 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,780,579 - 32,830,478 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,668,669 - 32,758,618 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,013,800 - 33,103,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,054,003 - 33,103,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,469,126 - 32,558,931 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,827,460 - 32,917,253 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,997,818 - 33,087,850 (+)NCBIUU_Cfam_GSD_1.0
Dennd6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118174,801,419 - 174,871,721 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364737,939,971 - 8,010,628 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364737,939,992 - 8,010,304 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND6A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,462,269 - 39,524,080 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,456,957 - 39,524,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,386,676 - 43,444,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DENND6A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,925,960 - 18,993,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,924,829 - 18,993,575 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,875,453 - 147,945,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000014218   ⟹   ENSHGLP00000014075
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624821376,525 - 446,583 (-)Ensembl
RefSeq Acc Id: XM_004864224   ⟹   XP_004864281
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624821374,615 - 446,656 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004864281 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014075
RefSeq Acc Id: XP_004864281   ⟸   XM_004864224
- UniProtKB: A0AAX6Q3G0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014075   ⟸   ENSHGLT00000014218


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010055 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014218 ENTREZGENE
NCBI Gene Dennd6a ENTREZGENE
UniProt A0AAX6Q3G0 ENTREZGENE, UniProtKB/TrEMBL