Plekhg5 (pleckstrin homology and RhoGEF domain containing G5) - Rat Genome Database

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Gene: Plekhg5 (pleckstrin homology and RhoGEF domain containing G5) Heterocephalus glaber
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Symbol: Plekhg5
Name: pleckstrin homology and RhoGEF domain containing G5
RGD ID: 18922933
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN endothelial cell chemotaxis (ortholog); endothelial cell migration (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 14 (ortholog); autosomal recessive distal hereditary motor neuronopathy 4 (ortholog); Charcot-Marie-Tooth disease recessive intermediate C (ortholog); FOUND IN cell-cell junction (ortholog); cytoplasm (ortholog); lamellipodium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family G member 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248184,990,808 - 5,009,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248184,990,321 - 5,010,308 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Plekhg5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248184,990,808 - 5,009,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248184,990,321 - 5,010,308 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PLEKHG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,467,122 - 6,520,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,467,122 - 6,520,074 (-)EnsemblGRCh38hg38GRCh38
GRCh3716,527,182 - 6,580,152 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,448,739 - 6,502,656 (-)NCBINCBI36Build 36hg18NCBI36
Celera15,640,600 - 5,693,925 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,673,695 - 5,727,849 (-)NCBIHuRef
CHM1_116,514,665 - 6,568,791 (-)NCBICHM1_1
T2T-CHM13v2.015,992,764 - 6,045,736 (-)NCBIT2T-CHM13v2.0
Plekhg5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,156,890 - 152,199,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,156,955 - 152,199,857 (+)EnsemblGRCm39 Ensembl
GRCm384152,072,433 - 152,115,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,072,498 - 152,115,400 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,470,828 - 151,489,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364150,940,519 - 150,959,200 (+)NCBIMGSCv36mm8
Celera4154,383,207 - 154,401,930 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map482.86NCBI
Plekhg5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,860,730 - 167,904,229 (+)NCBIGRCr8
mRatBN7.25162,577,999 - 162,621,518 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,578,071 - 162,621,513 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,281,116 - 165,324,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,102,520 - 167,145,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,064,724 - 167,108,066 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,244,778 - 169,288,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,244,778 - 169,288,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,803,041 - 172,846,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,301,095 - 169,344,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,311,282 - 169,354,321 (+)NCBI
Celera5160,810,630 - 160,853,658 (+)NCBICelera
Cytogenetic Map5q36NCBI
Plekhg5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,107,024 - 6,121,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,099,654 - 6,121,805 (+)NCBIChiLan1.0ChiLan1.0
PLEKHG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,707,604 - 221,760,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,349,975 - 220,402,801 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015,228,681 - 5,259,554 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,481,341 - 6,511,652 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,481,782 - 6,535,643 (-)Ensemblpanpan1.1panPan2
PLEKHG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,321,453 - 60,347,393 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,321,465 - 60,348,088 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,331,033 - 60,357,773 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,537,129 - 60,563,846 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,532,155 - 60,570,971 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,536,427 - 60,563,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,403,196 - 60,429,897 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,804,787 - 60,831,497 (-)NCBIUU_Cfam_GSD_1.0
Plekhg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,770,105 - 30,801,791 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366231,255,096 - 1,279,349 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366231,255,350 - 1,279,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHG5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,321,534 - 67,362,838 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,316,818 - 67,373,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,274,608 - 62,319,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,223,074 - 125,276,115 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,244,593 - 125,275,676 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,271,045 - 29,331,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000011276   ⟹   ENSHGLP00000011152
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248184,990,808 - 5,009,788 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000011277   ⟹   ENSHGLP00000011153
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248184,996,120 - 5,009,788 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000011278   ⟹   ENSHGLP00000011154
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248184,999,778 - 5,009,788 (+)Ensembl
RefSeq Acc Id: XM_004863711   ⟹   XP_004863768
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248184,993,081 - 5,010,308 (+)NCBI
RefSeq Acc Id: XM_004863712   ⟹   XP_004863769
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248184,993,081 - 5,009,601 (+)NCBI
RefSeq Acc Id: XM_013065159   ⟹   XP_012920613
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248184,990,321 - 5,010,308 (+)NCBI
RefSeq Acc Id: XM_013065160   ⟹   XP_012920614
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248184,990,321 - 5,009,601 (+)NCBI
RefSeq Acc Id: XM_021243376   ⟹   XP_021099035
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248185,000,312 - 5,010,308 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004863768 (Get FASTA)   NCBI Sequence Viewer  
  XP_004863769 (Get FASTA)   NCBI Sequence Viewer  
  XP_012920613 (Get FASTA)   NCBI Sequence Viewer  
  XP_012920614 (Get FASTA)   NCBI Sequence Viewer  
  XP_021099035 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011152
RefSeq Acc Id: XP_012920613   ⟸   XM_013065159
- Peptide Label: isoform X4
- UniProtKB: G5C562 (UniProtKB/TrEMBL),   A0AAX6QH61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012920614   ⟸   XM_013065160
- Peptide Label: isoform X5
- UniProtKB: G5C562 (UniProtKB/TrEMBL),   A0AAX6QLR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004863768   ⟸   XM_004863711
- Peptide Label: isoform X1
- UniProtKB: G5C562 (UniProtKB/TrEMBL),   A0AAX6Q2P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004863769   ⟸   XM_004863712
- Peptide Label: isoform X2
- UniProtKB: G5C562 (UniProtKB/TrEMBL),   A0AAX6PZE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021099035   ⟸   XM_021243376
- Peptide Label: isoform X3
- UniProtKB: G5C562 (UniProtKB/TrEMBL),   A0AAX6RSI8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011154   ⟸   ENSHGLT00000011278
Ensembl Acc Id: ENSHGLP00000011153   ⟸   ENSHGLT00000011277
Ensembl Acc Id: ENSHGLP00000011152   ⟸   ENSHGLT00000011276


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008004 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000011276 ENTREZGENE
Gene3D-CATH Dbl homology (DH) domain UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PKHG5/7 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Plekhg5 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DBL homology domain (DH-domain) UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Ubiquitin-like UniProtKB/TrEMBL
UniProt A0AAX6PZE8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q2P3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QH61 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QLR1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RSI8 ENTREZGENE, UniProtKB/TrEMBL
  G5C562 ENTREZGENE, UniProtKB/TrEMBL