Cracr2a (calcium release activated channel regulator 2A) - Rat Genome Database

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Gene: Cracr2a (calcium release activated channel regulator 2A) Heterocephalus glaber
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Symbol: Cracr2a
Name: calcium release activated channel regulator 2A
RGD ID: 18918805
Description: ENCODES a protein that exhibits calcium ion binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN activation of store-operated calcium channel activity (ortholog); endosomal transport (ortholog); positive regulation of calcium ion transport (ortholog); ASSOCIATED WITH Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN cytoplasm (ortholog); Golgi membrane (ortholog); immunological synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: EF-hand calcium-binding domain-containing protein 4B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624860849,278 - 959,584 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624860846,420 - 959,600 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Cracr2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624860849,278 - 959,584 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624860846,420 - 959,600 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CRACR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,615,328 - 3,753,109 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,606,633 - 3,764,819 (-)EnsemblGRCh38hg38GRCh38
GRCh37123,724,494 - 3,862,275 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,627,370 - 3,732,524 (-)NCBINCBI36Build 36hg18NCBI36
Celera125,338,122 - 5,484,209 (-)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef123,580,322 - 3,718,288 (-)NCBIHuRef
CHM1_1123,723,522 - 3,861,691 (-)NCBICHM1_1
T2T-CHM13v2.0123,621,867 - 3,761,227 (-)NCBIT2T-CHM13v2.0
Cracr2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,538,299 - 127,651,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,538,301 - 127,651,211 (+)EnsemblGRCm39 Ensembl
GRCm386127,561,062 - 127,674,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,561,338 - 127,674,248 (+)EnsemblGRCm38mm10GRCm38
MGSCv376127,527,993 - 127,579,956 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366127,543,594 - 127,595,557 (+)NCBIMGSCv36mm8
Celera6129,252,736 - 129,301,397 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map662.39NCBI
Cracr2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84162,094,247 - 162,207,926 (+)NCBIGRCr8
mRatBN7.24160,428,987 - 160,517,427 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4160,408,077 - 160,518,107 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.04160,143,160 - 160,238,744 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4160,168,297 - 160,194,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04231,376,178 - 231,488,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44164,040,029 - 164,117,326 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4149,140,524 - 149,234,364 (+)NCBICelera
Cytogenetic Map4q42NCBI
Cracr2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554131,429,021 - 1,543,662 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554131,425,165 - 1,544,226 (-)NCBIChiLan1.0ChiLan1.0
CRACR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2109,153,765 - 9,306,635 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,155,896 - 9,303,324 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0123,729,241 - 3,875,715 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,655,031 - 3,799,159 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,655,031 - 3,737,592 (-)Ensemblpanpan1.1panPan2
CRACR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12741,090,906 - 41,228,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2741,094,009 - 41,217,919 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,427,923 - 5,590,861 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02741,448,803 - 41,612,007 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2741,448,723 - 41,576,252 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12741,386,343 - 41,549,254 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02741,361,319 - 41,524,693 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0274,790,233 - 4,953,259 (-)NCBIUU_Cfam_GSD_1.0
Cracr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945105,213,881 - 105,306,230 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366063,882,276 - 3,955,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366063,880,214 - 3,970,278 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRACR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,533,033 - 66,647,748 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1566,574,758 - 66,650,447 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,883,366 - 68,925,027 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRACR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,659,745 - 3,815,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,667,647 - 3,743,026 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660634,443,332 - 4,579,215 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004869353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01093097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000005227   ⟹   ENSHGLP00000005160
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624860849,278 - 959,584 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000005228   ⟹   ENSHGLP00000005161
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624860886,031 - 918,325 (-)Ensembl
RefSeq Acc Id: XM_004869353   ⟹   XP_004869410
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624860846,420 - 959,600 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004869410 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005160
RefSeq Acc Id: XP_004869410   ⟸   XM_004869353
- UniProtKB: G5AS08 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000005161   ⟸   ENSHGLT00000005228
Ensembl Acc Id: ENSHGLP00000005160   ⟸   ENSHGLT00000005227


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003776 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000005227 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/TrEMBL
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Rab UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
NCBI Gene Cracr2a ENTREZGENE
PANTHER CALCIUM RELEASE-ACTIVATED CHANNEL REGULATOR 2AB UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE ARF UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
SMART ARF UniProtKB/TrEMBL
  EFh UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP EF-hand UniProtKB/TrEMBL
  P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
UniProt A0AAX6Q7C2_HETGA UniProtKB/TrEMBL
  G5AS08 ENTREZGENE, UniProtKB/TrEMBL