Nt5dc2 (5'-nucleotidase domain containing 2) - Rat Genome Database

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Gene: Nt5dc2 (5'-nucleotidase domain containing 2) Heterocephalus glaber
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Symbol: Nt5dc2
Name: 5'-nucleotidase domain containing 2
RGD ID: 18911745
Description: ENCODES a protein that exhibits 5'-nucleotidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of catecholamine metabolic process (ortholog); negative regulation of dopamine biosynthetic process (ortholog); negative regulation of oxidoreductase activity (ortholog); ASSOCIATED WITH congenital disorder of glycosylation In (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5'-nucleotidase domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,675,430 - 4,685,553 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,675,430 - 4,684,074 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
mitochondrion  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Nt5dc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,675,430 - 4,685,553 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,675,430 - 4,684,074 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NT5DC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,524,387 - 52,535,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,524,385 - 52,535,054 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,558,403 - 52,569,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,533,443 - 52,557,496 (-)NCBINCBI36Build 36hg18NCBI36
Celera352,537,844 - 52,548,598 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,621,260 - 52,631,693 (-)NCBIHuRef
CHM1_1352,510,752 - 52,522,876 (-)NCBICHM1_1
T2T-CHM13v2.0352,557,295 - 52,567,927 (-)NCBIT2T-CHM13v2.0
Nt5dc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,853,046 - 30,861,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,853,010 - 30,861,081 (+)EnsemblGRCm39 Ensembl
GRCm381431,131,089 - 31,139,124 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,131,053 - 31,139,124 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,948,039 - 31,952,310 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,958,791 - 29,968,185 (+)NCBIMGSCv36mm8
Celera1427,393,412 - 27,397,684 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Nt5dc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,328,925 - 6,336,978 (+)NCBIGRCr8
mRatBN7.2166,322,485 - 6,330,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,322,236 - 6,330,537 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,334,474 - 6,342,552 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,479,698 - 7,487,777 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,341,433 - 6,349,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,212,488 - 7,220,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,212,488 - 7,220,540 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,141,051 - 7,149,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,559,619 - 6,567,690 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,559,616 - 6,567,687 (+)NCBI
Celera168,858,685 - 8,866,968 (-)NCBICelera
Cytogenetic Map16p16NCBI
Nt5dc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,517,943 - 2,526,423 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,517,943 - 2,526,423 (-)NCBIChiLan1.0ChiLan1.0
NT5DC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,519,179 - 52,529,264 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,523,951 - 52,534,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,466,032 - 52,475,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,694,012 - 53,703,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,694,113 - 53,706,537 (-)Ensemblpanpan1.1panPan2
NT5DC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,241,251 - 37,249,872 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,240,038 - 37,249,832 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,222,956 - 37,231,703 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,590,578 - 37,599,325 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,589,615 - 37,599,285 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,955,136 - 36,963,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,363,767 - 37,372,505 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,642,003 - 37,650,749 (+)NCBIUU_Cfam_GSD_1.0
Nt5dc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,224,563 - 170,234,687 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,360,009 - 3,373,462 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,363,134 - 3,372,535 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5DC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,659,249 - 34,679,535 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,659,249 - 34,679,530 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,872,007 - 37,876,749 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NT5DC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,892,078 - 13,903,043 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041152,998,572 - 153,007,992 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004868   ⟹   ENSHGLP00000004804
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248224,675,430 - 4,685,553 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004869   ⟹   ENSHGLP00000004805
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248224,678,340 - 4,685,553 (+)Ensembl
RefSeq Acc Id: XM_004864389   ⟹   XP_004864446
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248224,675,430 - 4,684,074 (+)NCBI
RefSeq Acc Id: XM_004864390   ⟹   XP_004864447
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248224,678,538 - 4,683,981 (+)NCBI
RefSeq Acc Id: XM_004864391   ⟹   XP_004864448
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248224,675,723 - 4,683,981 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004864446 (Get FASTA)   NCBI Sequence Viewer  
  XP_004864447 (Get FASTA)   NCBI Sequence Viewer  
  XP_004864448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004804
  ENSHGLP00000004805
RefSeq Acc Id: XP_004864446   ⟸   XM_004864389
- Peptide Label: isoform X1
- UniProtKB: G5BUM5 (UniProtKB/TrEMBL),   A0AAX6Q1B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004864448   ⟸   XM_004864391
- Peptide Label: isoform X3
- UniProtKB: G5BUM5 (UniProtKB/TrEMBL),   A0AAX6Q2C9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004864447   ⟸   XM_004864390
- Peptide Label: isoform X2
- UniProtKB: G5BUM5 (UniProtKB/TrEMBL),   A0AAX6Q2J5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004805   ⟸   ENSHGLT00000004869
Ensembl Acc Id: ENSHGLP00000004804   ⟸   ENSHGLT00000004868


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003527 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004868 ENTREZGENE
  ENSHGLT00000004869 ENTREZGENE
Gene3D-CATH HAD superfamily/HAD-like UniProtKB/TrEMBL
InterPro HAD-like_sf UniProtKB/TrEMBL
  HAD-SF_hydro_IG_5-nucl UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  Pur_nucleotidase UniProtKB/TrEMBL
NCBI Gene Nt5dc2 ENTREZGENE
PANTHER 5'-NUCLEOTIDASE DOMAIN-CONTAINING UniProtKB/TrEMBL
  5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam 5_nucleotid UniProtKB/TrEMBL
PIRSF Purine_5'-nucleotidase UniProtKB/TrEMBL
Superfamily-SCOP HAD-like UniProtKB/TrEMBL
UniProt A0AAX6Q1B1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q2C9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q2J5 ENTREZGENE, UniProtKB/TrEMBL
  G5BUM5 ENTREZGENE, UniProtKB/TrEMBL