BHMT2 (betaine--homocysteine S-methyltransferase 2) - Rat Genome Database

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Gene: BHMT2 (betaine--homocysteine S-methyltransferase 2) Chlorocebus sabaeus
Analyze
Symbol: BHMT2
Name: betaine--homocysteine S-methyltransferase 2
RGD ID: 18766170
Description: ENCODES a protein that exhibits betaine-homocysteine S-methyltransferase activity (ortholog); INVOLVED IN amino-acid betaine metabolic process (ortholog); ASSOCIATED WITH cleft lip (ortholog); cleft palate (ortholog); congenital heart disease (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: S-methylmethionine--homocysteine S-methyltransferase BHMT2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,289,836 - 73,310,312 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,289,652 - 73,312,358 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604922,136,327 - 22,156,786 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BHMT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,289,836 - 73,310,312 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,289,652 - 73,312,358 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604922,136,327 - 22,156,786 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
BHMT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38579,069,767 - 79,090,069 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl579,069,767 - 79,090,069 (+)EnsemblGRCh38hg38GRCh38
GRCh37578,365,590 - 78,385,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36578,401,339 - 78,421,045 (+)NCBINCBI36Build 36hg18NCBI36
Build 34578,401,338 - 78,421,029NCBI
Celera574,258,430 - 74,278,792 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef573,571,483 - 73,591,845 (+)NCBIHuRef
CHM1_1577,798,019 - 77,818,372 (+)NCBICHM1_1
T2T-CHM13v2.0579,550,871 - 79,571,174 (+)NCBIT2T-CHM13v2.0
Bhmt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,792,605 - 93,810,810 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,792,228 - 93,810,810 (-)EnsemblGRCm39 Ensembl
GRCm381393,656,097 - 93,674,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,655,720 - 93,674,302 (-)EnsemblGRCm38mm10GRCm38
MGSCv371394,426,052 - 94,444,257 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361394,757,008 - 94,775,032 (-)NCBIMGSCv36mm8
Celera1397,262,133 - 97,280,354 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.88NCBI
Bhmt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,630,502 - 26,647,450 (-)NCBIGRCr8
mRatBN7.2224,895,525 - 24,912,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,895,533 - 24,912,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx231,922,826 - 31,939,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0230,023,092 - 30,040,035 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,848,839 - 24,865,761 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,272,320 - 23,289,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,272,328 - 23,289,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0242,452,894 - 42,469,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4223,958,062 - 23,976,438 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1223,878,437 - 23,896,807 (-)NCBI
Celera220,969,823 - 20,986,770 (-)NCBICelera
Cytogenetic Map2q12NCBI
BHMT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2436,217,192 - 36,235,946 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1534,370,819 - 34,389,555 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0536,223,429 - 36,242,187 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1536,713,179 - 36,725,144 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl536,670,854 - 36,728,993 (-)Ensemblpanpan1.1panPan2
BHMT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,775,779 - 27,804,603 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,776,084 - 27,789,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha329,015,000 - 29,030,182 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0327,694,621 - 27,709,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,694,625 - 27,708,820 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,633,714 - 27,648,761 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,612,238 - 27,627,369 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,892,957 - 27,908,103 (-)NCBIUU_Cfam_GSD_1.0
LOC101971919
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,945,559 - 183,959,144 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365496,899,948 - 6,914,263 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365496,900,075 - 6,914,217 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHMT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl287,866,621 - 87,882,716 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1287,866,631 - 87,882,623 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2289,459,626 - 89,475,622 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Bhmt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248693,576,369 - 3,599,275 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248693,571,154 - 3,596,389 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
74 36 18 34 34 58 20

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007976301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000013342   ⟹   ENSCSAP00000011344
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl473,289,652 - 73,312,358 (+)Ensembl
RefSeq Acc Id: XM_007976301   ⟹   XP_007974492
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1473,289,836 - 73,310,312 (+)NCBI
Vero_WHO_p1.0NW_02366604922,136,327 - 22,156,786 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007974492 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011344
  ENSCSAP00000011344.1
RefSeq Acc Id: XP_007974492   ⟸   XM_007976301
- UniProtKB: A0A0D9RRV5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000011344   ⟸   ENSCSAT00000013342


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015246 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013342.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.330 UniProtKB/TrEMBL
InterPro Betaine-hCys_S-MeTrfase_BHMT UniProtKB/TrEMBL
  BHMT UniProtKB/TrEMBL
  HCY_dom UniProtKB/TrEMBL
  HCY_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103223592 UniProtKB/TrEMBL
NCBI Gene BHMT2 ENTREZGENE
PANTHER BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 UniProtKB/TrEMBL
  S-METHYLMETHIONINE--HOMOCYSTEINE S-METHYLTRANSFERASE BHMT2 UniProtKB/TrEMBL
Pfam S-methyl_trans UniProtKB/TrEMBL
PIRSF Betaine_HMT UniProtKB/TrEMBL
PROSITE HCY UniProtKB/TrEMBL
Superfamily-SCOP SSF82282 UniProtKB/TrEMBL
UniProt A0A0D9RRV5 ENTREZGENE, UniProtKB/TrEMBL