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Gene: BEST4 (bestrophin 4) Chlorocebus sabaeus

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Symbol:

BEST4

Name:

bestrophin 4

RGD ID:

18701445

Description:

ENCODES a protein that exhibits bicarbonate channel activity (inferred); channel activity (inferred); chloride channel activity (inferred); INVOLVED IN bicarbonate transport (inferred); chloride transmembrane transport (inferred); chloride transport (inferred); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN chloride channel complex (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

bestrophin-4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BEST4 (bestrophin 4)	NCBI	Ortholog
Rattus norvegicus (Norway rat):	Best4 (bestrophin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Best4 (bestrophin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BEST4 (bestrophin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BEST4 (bestrophin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Best4 (bestrophin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BEST4 (bestrophin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Best4 (bestrophin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	87,997,070 - 88,008,475 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	88,002,728 - 88,009,035 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	28,929,611 - 28,933,959 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bicarbonate transport (IEA)

chloride transmembrane transport (IEA)

chloride transport (IEA)

monoatomic ion transmembrane transport (IEA)

Cellular Component

chloride channel complex (IEA)

plasma membrane (IEA)

Molecular Function

bicarbonate channel activity (IEA)

channel activity (IEA)

chloride channel activity (IEA)

intracellularly calcium-gated chloride channel activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

BEST4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	87,997,070 - 88,008,475 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	88,002,728 - 88,009,035 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	28,929,611 - 28,933,959 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

BEST4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	44,781,840 - 44,792,828 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	44,781,836 - 44,788,170 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	45,249,257 - 45,253,842 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	45,021,844 - 45,026,013 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	44,918,351 - 44,922,470	NCBI
Celera	1	43,532,138 - 43,536,307 (-)	NCBI		Celera
Cytogenetic Map	1	p34.1	NCBI
HuRef	1	43,362,307 - 43,366,475 (-)	NCBI		HuRef
CHM1_1	1	45,365,170 - 45,369,339 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	44,652,829 - 44,664,929 (-)	NCBI		T2T-CHM13v2.0

Best4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	135,858,774 - 135,865,624 (+)	NCBI		GRCr8
mRatBN7.2	5	130,622,194 - 130,629,045 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	130,623,438 - 130,627,099 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	136,013,978 - 136,017,742 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	136,014,017 - 136,017,677 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	139,806,969 - 139,810,707 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	137,459,781 - 137,463,519 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	129,144,974 - 129,148,738 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Best4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	13,434,429 - 13,439,108 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	13,434,429 - 13,439,108 (+)	NCBI	ChiLan1.0	ChiLan1.0

BEST4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	182,006,378 - 182,024,437 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	181,148,051 - 181,165,859 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	44,087,062 - 44,104,995 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	45,453,277 - 45,456,691 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	45,452,078 - 45,456,691 (-)	Ensembl	panpan1.1		panPan2

BEST4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	15,535,179 - 15,539,047 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	15,535,186 - 15,538,526 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	15,655,025 - 15,659,367 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	15,690,376 - 15,694,718 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	15,690,717 - 15,694,187 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	15,487,545 - 15,491,887 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	15,554,843 - 15,559,185 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	15,627,893 - 15,632,234 (+)	NCBI		UU_Cfam_GSD_1.0

Best4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	60,188,095 - 60,192,387 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	26,012,887 - 26,016,511 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	26,012,887 - 26,016,511 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BEST4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	166,528,987 - 166,546,996 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	166,540,767 - 166,547,149 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	154,032,949 - 154,038,248 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Best4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624906	676,210 - 679,503 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624906	676,201 - 680,424 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in BEST4
187 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
72	32	20	32	32	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007978980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000017329 ⟹ ENSCSAP00000016810

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	88,002,728 - 88,009,035 (+)	Ensembl

RefSeq Acc Id:

XM_007978980 ⟹ XP_007977171

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	87,997,070 - 88,008,475 (+)	NCBI
Vero_WHO_p1.0	NW_023666033	28,929,611 - 28,933,959 (-)	NCBI

Sequence:

show sequence

TCGAATTCCTGGACTCAAGCGATCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAG
CCACCATGCTTGGGTCAGAATCTCTTGAGTGTCATGTCACAGAGGCCAACGGAGTAGGGTCAAG
AATGAGAGATGCAAGGAAACTTGCAGAAGAGAACCAGCTCACGGTGCGGGGGGAGGAGCTTCCC
AAAGCAAGACAGAGGCAGGACCACCACTCTAGGGATTTTTCAGTATTCACTTACCTCAGCACTG
GGACGGTTCAAGCAATTCTCCTGCGTCAGCCTCCTACGTACCTGGAACTACAGGCTCCCAGCAC
CATGACGGTTTCATATACTCTCAAAGTGGCGGAGGCCCGCTTCGGAGGTTTCTCTGGCCTGCTT
CTCCGTTGGAGGGGAAGCATCTACAAGCTCCTCTACAAGGAATTCCTCCTCTTCGGGGCCTTGT
ACGCTGTGCTTAGCATCACCTACCGGCTGCTGCTGACCCAGGAGCAGAAGCACGTGTATGCTCA
GGTGGCCCGGTACTGCAACCGTTCAGCGGACCTCATCCCCTTGTCCTTTGTATTGGGTTTCTAT
GTGACTCTCGTGGTGAACCGCTGGTGGTCCCAGTACACAAGCATCCCGCTGCCAGACCAGCTGA
TGTGCGTCATCTCGGCTAGCGTGCACGGCGTAGACCAGCGGGGCCGCCTGCTGCGCCGCACCCT
CATCCGCTACGCGAACCTGGCGTCGGTGCTGGTGCTGCGCTCGGTCAGCACCCGCGTGCTCAAG
CGCTTCCCCACCATGGAGCACGTGGTGGATGCAGGTTTCATGTCCCAGGAAGAGAGGAAAAAGT
TTGAGAGCCTGAAATCCGACTTCAACAAGTACTGGGTCCCCTGCGTCTGGTTCACCAACCTGGC
GGCCCAGGCCCGGAGGGACGGGCGAATCCGTGATGATATCGCTCTCTGTCTACTTTTGGAAGAG
CTGAACAAGTACCGAGCCAAGTGCAGCATGCTATTCCACTATGACTGGATCAGCATCCCCCTCG
TCTACACCCAAGTGGTGACCATAGCCGTCTACTCCTTCTTTGCCCTCTCCCTGGTTGGCCGCCA
GTTTGTGGAGCCAGAGGCAGGGGCTGCCAAACCTCAGAAGCTTCTGAAGCCAGGCCAGGAGCCA
GCCCCAGCCTTGGGAGACCCGGACATGTATGTGCCTCTCACCACTCTGCTGCAGTTCTTCTTCT
ATGCTGGCTGGCTCAAGGTGGCTGAACAGATCATCAACCCGTTTGGTGAGGATGATGACGACTT
TGAGACAAACCAGCTCATAGACCGTAACTTGCAGGTGTCCTTGCTATCTGTGGACGAAATGTAC
CAGAACCTTCCCCCCGCTGAGAAGGACCAGTACTGGGATGAGGACCAGCCGCAGCCACCCTACA
CTGTGGCCACGGCGGCTGAGTCTCTGCGGCCCTCATTCCTGGGCTCCACCTTCAACCTGCGCAT
GAGCGACGACCCTGAGCAGAGCCTGCAGGTGGAGGCGTCCCCCGGGTCGGGTCGGCCCGCGCCT
GCCGCGCAGACCCCGTTGCTCGGCCGCTTCCTGGGCGTAGGGGCGCCCTCCCCGGCCATCAGCC
TCCGGAACTTCGGCCGCGCGCGAGGGACCCCGCGCCCCCCGCATCTGCTACGCTTCCGGGCCGA
GGAGGGCGGCGACCCCGAGGCCGCAGCCCGCATCGAGGAGGAGACGGCGGAGTCCGGGGACGAG
GCCCTGGAGCCCTGAGCTTTTACAAGCCTTGTTCCATGGTGAGAACGGTCATCTGTGAAGGTGG
TAGAAATGGAGAGTGGATGGATTTCAAGACTTTAGAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007977171	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000016810.1

RefSeq Acc Id:	XP_007977171 ⟸ XM_007978980
- UniProtKB:	A0A0D9S7H1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000016810 ⟸ ENSCSAT00000017329

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000001204	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017329.1	UniProtKB/TrEMBL
InterPro	Bestrophin	UniProtKB/TrEMBL
	Bestrophin/UPF0187	UniProtKB/TrEMBL
NCBI Gene	BEST4	ENTREZGENE
PANTHER	BESTROPHIN-4	UniProtKB/TrEMBL
	PTHR10736	UniProtKB/TrEMBL
Pfam	Bestrophin	UniProtKB/TrEMBL
UniProt	A0A0D9S7H1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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