PFN4 (profilin family member 4) - Rat Genome Database

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Gene: PFN4 (profilin family member 4) Chlorocebus sabaeus
Analyze
Symbol: PFN4
Name: profilin family member 4
RGD ID: 18665179
Description: ENCODES a protein that exhibits actin binding (inferred); actin monomer binding (inferred); INVOLVED IN acrosome assembly (inferred); flagellated sperm motility (inferred); manchette assembly (inferred); FOUND IN cell cortex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: profilin-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11483,530,834 - 83,538,704 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1483,531,482 - 83,540,305 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604528,629,446 - 28,637,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell cortex  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PFN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11483,530,834 - 83,538,704 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1483,531,482 - 83,540,305 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604528,629,446 - 28,637,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PFN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,114,809 - 24,123,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,114,809 - 24,123,464 (-)EnsemblGRCh38hg38GRCh38
GRCh37224,337,679 - 24,346,204 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,191,745 - 24,199,655 (-)NCBINCBI36Build 36hg18NCBI36
Build 34224,249,894 - 24,257,802NCBI
Celera224,178,574 - 24,186,481 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,077,093 - 24,085,037 (-)NCBIHuRef
CHM1_1224,267,633 - 24,275,540 (-)NCBICHM1_1
T2T-CHM13v2.0224,149,512 - 24,158,188 (-)NCBIT2T-CHM13v2.0
Pfn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,819,010 - 4,828,813 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,819,022 - 4,828,813 (+)EnsemblGRCm39 Ensembl
GRCm38124,769,015 - 4,778,813 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,769,022 - 4,778,813 (+)EnsemblGRCm38mm10GRCm38
MGSCv37124,776,101 - 4,785,072 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36124,786,316 - 4,795,287 (+)NCBIMGSCv36mm8
Celera124,701,135 - 4,710,105 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map122.09NCBI
Pfn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8633,506,077 - 33,516,163 (+)NCBIGRCr8
mRatBN7.2627,786,619 - 27,796,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,786,619 - 27,796,710 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx628,078,875 - 28,088,958 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0628,394,789 - 28,404,862 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,869,330 - 27,879,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0630,027,915 - 30,038,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl630,027,915 - 30,038,000 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0639,849,111 - 39,859,332 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera627,256,362 - 27,266,443 (+)NCBICelera
Cytogenetic Map6q14NCBI
Pfn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,299,451 - 6,307,176 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554696,299,451 - 6,306,564 (-)NCBIChiLan1.0ChiLan1.0
PFN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212102,395,764 - 102,407,250 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A102,399,787 - 102,411,214 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,110,565 - 24,120,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,209,163 - 24,217,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,209,163 - 24,217,262 (-)Ensemblpanpan1.1panPan2
PFN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11718,571,201 - 18,579,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1718,573,445 - 18,578,818 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1718,469,095 - 18,477,470 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01718,847,785 - 18,853,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1718,742,935 - 18,853,529 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11718,582,464 - 18,590,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01718,590,900 - 18,599,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01718,631,691 - 18,640,075 (-)NCBIUU_Cfam_GSD_1.0
Pfn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629262,947,391 - 62,951,384 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,888,968 - 7,892,000 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,888,211 - 7,891,273 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3114,578,199 - 114,585,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13114,578,264 - 114,585,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,842,829 - 121,849,795 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pfn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247386,419,204 - 6,423,981 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247386,415,391 - 6,424,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 18 60
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000006458   ⟹   ENSCSAP00000004662
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1483,531,482 - 83,540,305 (+)Ensembl
RefSeq Acc Id: XM_007971298   ⟹   XP_007969489
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11483,531,504 - 83,538,704 (+)NCBI
Vero_WHO_p1.0NW_02366604528,629,446 - 28,636,295 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007971299   ⟹   XP_007969490
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11483,531,504 - 83,538,704 (+)NCBI
Vero_WHO_p1.0NW_02366604528,629,446 - 28,636,595 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038006632   ⟹   XP_037862560
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604528,634,913 - 28,637,592 (-)NCBI
RefSeq Acc Id: XM_038006633   ⟹   XP_037862561
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604528,629,446 - 28,636,817 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007969489 (Get FASTA)   NCBI Sequence Viewer  
  XP_007969490 (Get FASTA)   NCBI Sequence Viewer  
  XP_037862560 (Get FASTA)   NCBI Sequence Viewer  
  XP_037862561 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004662
  ENSCSAP00000004662.1
Reference Protein Sequences
RefSeq Acc Id: XP_007969489   ⟸   XM_007971298
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R7S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007969490   ⟸   XM_007971299
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R7S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004662   ⟸   ENSCSAT00000006458
RefSeq Acc Id: XP_037862561   ⟸   XM_038006633
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037862560   ⟸   XM_038006632
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008406 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006458.1 UniProtKB/TrEMBL
Gene3D-CATH Dynein light chain 2a, cytoplasmic UniProtKB/TrEMBL
InterPro PFN UniProtKB/TrEMBL
  PFN UniProtKB/TrEMBL
  PFN_sf UniProtKB/TrEMBL
NCBI Gene PFN4 ENTREZGENE
PANTHER PROFILIN-4 UniProtKB/TrEMBL
  PTHR11604 UniProtKB/TrEMBL
Pfam Profilin UniProtKB/TrEMBL
SMART PROF UniProtKB/TrEMBL
Superfamily-SCOP SSF55770 UniProtKB/TrEMBL
UniProt A0A0D9R7S3 ENTREZGENE, UniProtKB/TrEMBL