DAZL (deleted in azoospermia like)

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Gene: DAZL (deleted in azoospermia like) Chlorocebus sabaeus

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Symbol:

DAZL

Name:

deleted in azoospermia like

RGD ID:

18635951

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN female meiosis II (ortholog); germ cell development (ortholog); oocyte maturation (ortholog); ASSOCIATED WITH 3p deletion syndrome (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN nucleus (ortholog); ribosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

deleted in azoospermia protein 3-like; deleted in azoospermia-like; LOC103247129

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	61,398,284 - 61,413,222 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	61,398,400 - 61,407,054 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	34,436,747 - 34,453,232 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3p deletion syndrome (ISO)

Testicular Germ Cell Tumor (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

3'-UTR-mediated mRNA stabilization (IEA)

cell differentiation (IEA)

female meiosis II (ISO)

germ cell development (ISO)

oocyte maturation (ISO)

positive regulation of meiotic nuclear division (ISO)

positive regulation of translational initiation (IEA)

regulation of translation (IEA)

spermatogenesis (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (ISO)

protein-containing complex (IEA)

ribosome (ISO)

Molecular Function

identical protein binding (ISO)

mRNA 3'-UTR binding (IEA)

protein binding (ISO)

RNA binding (IEA)

translation activator activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

DAZL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	61,398,284 - 61,413,222 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	61,398,400 - 61,407,054 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	34,436,747 - 34,453,232 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DAZL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	16,586,792 - 16,605,423 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	16,586,792 - 16,670,306 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	16,628,299 - 16,646,930 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	16,603,303 - 16,622,010 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	16,603,306 - 16,622,010	NCBI
Celera	3	16,567,358 - 16,586,066 (-)	NCBI		Celera
Cytogenetic Map	3	p24.3	NCBI
HuRef	3	16,562,073 - 16,580,780 (-)	NCBI		HuRef
CHM1_1	3	16,579,744 - 16,598,453 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	16,587,918 - 16,606,550 (-)	NCBI		T2T-CHM13v2.0

Dazl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	50,586,422 - 50,600,627 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	50,586,423 - 50,600,664 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	50,279,393 - 50,293,620 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	50,279,395 - 50,293,636 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	50,418,719 - 50,432,924 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	49,744,968 - 49,759,166 (-)	NCBI		MGSCv36	mm8
Celera	17	53,721,165 - 53,735,366 (-)	NCBI		Celera
Cytogenetic Map	17	C	NCBI
cM Map	17	25.86	NCBI

Dazl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	18,193,363 - 18,210,100 (+)	NCBI		GRCr8
mRatBN7.2	9	10,695,593 - 10,712,330 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	10,695,592 - 10,712,323 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	19,196,599 - 19,213,357 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	24,263,194 - 24,279,952 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	22,644,773 - 22,661,531 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	12,633,983 - 12,651,017 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	12,633,990 - 12,650,938 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	11,575,025 - 11,591,973 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	5,899,104 - 5,915,835 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	8,474,104 - 8,490,835 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

Dazl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	8,869,352 - 8,880,789 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	8,869,419 - 8,880,782 (-)	NCBI	ChiLan1.0	ChiLan1.0

DAZL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	16,570,582 - 16,592,426 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	16,575,345 - 16,597,189 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	16,514,327 - 16,625,601 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	16,851,158 - 16,963,004 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	16,851,158 - 16,862,963 (-)	Ensembl	panpan1.1		panPan2

DAZL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	26,194,061 - 26,212,506 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	26,169,469 - 26,187,771 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	26,695,154 - 26,713,476 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	26,694,909 - 26,712,429 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	26,396,512 - 26,414,786 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	26,457,954 - 26,476,206 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	26,706,974 - 26,725,278 (+)	NCBI		UU_Cfam_GSD_1.0

Dazl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	176,251,748 - 176,270,268 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936473	9,392,079 - 9,436,725 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DAZL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	3,764,784 - 3,782,818 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	3,762,896 - 3,783,848 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	4,036,653 - 4,056,742 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Dazl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624821	1,836,632 - 1,854,048 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
46	24	18	22	22	42	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008009234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000008030 ⟹ ENSCSAP00000006188

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	15	61,398,400 - 61,407,054 (-)	Ensembl

RefSeq Acc Id:

XM_008009234 ⟹ XP_008007425

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	15	61,398,284 - 61,413,222 (-)	NCBI
Vero_WHO_p1.0	NW_023666041	34,436,747 - 34,453,232 (-)	NCBI

Sequence:

show sequence

GGGGGCCTCAGCGTGGGGTGTGTGAGGCGTCCTGAAAGCAGGGCCCGCTAGCTAAGGGGGGCTG
GGCCGGAAGTGCTTCTGGTCTCCTCTCACCTGTCAGCTGCTGGGGACTTGCTGATGGCAGCTCC
CTCGTGCGGCGGCGACAGGCACAAAGCTCGCCTGACGCCATCTTTGTGGCACGAGTCTGCTGCA
AATCCTGAAACTCCAAACTCAACCATCTCCAGAGAAGCCAGCACCCAGTCCTCATCAGCTGCAA
CCAGCCAAGGCTATGTTTTACCAGAAGGCAAAATCATGCCAAACACTGTTTTTGTTGGAGGAAT
TGATGTTAGGATGGATGAAACTGAGATTAGAAGCTTCTTTGCTAGATATGGTTCAGTGAAAGAA
GTGAAGATAATCACTGATCGAACTGGTGTGTCCAAAGGCTATGGATTTGTTTCATTTTTTAATG
ACGTGGATGTGCAGAAGATAGTAGAATCACAGATAAATTTCCATGGTAAAAAGCTGAAGCTGGG
CCCTGCAATCAGGAAACAAAAAATACGTGCTCGTCATGTGCAGCCACGTCCTTTGGTTTTTAAT
CATCCTCCTCCACCACAGTTTCAGAATGTCTGGACTAATCCAAACACTGAAACTTACATGCAGC
CCCCAACCACGGTGAATCCTATAACTCAGTATGTTCAGGCATATCCTACTTACCCAAATTCACC
CGTTCAGGTCATCACTGGATATCAGTTGCCAGTATATAATTATCAGATGCCGCCACAGTGGCCT
GTTGGGGAGCAAAGGAGCTATGTTGTACCTCCGGCTTATTCAGCTGTTAACTACCACTGTAATG
AAGTTGATCCAGGAGCTGAAGTTGTGCCAAATGAATGCTCAGTTCATGAAGCTACTCCACCCTC
TGGAAATGGCCCACAAAAGAAATCTGTGGACCGAAGCATACAAACGGTGGTATCTTGTCTGTTT
AATCCAGAGAACAGACTGAGAAACACTGTTGTTACTCAAGATGACTACTTCAAGGATAAAAGAG
TGCATCACTTTAGAAGAAGTCGGGCAATGCTTAAATCTGTTTGATCCTCCTGGCTATGTAGTTT
CATGGGAAGTTGCTGGTTTTGAATATTAAGCTAAAAGTTTTCCACTATTATAGAAATTCTGAAT
TTTGGTAAATCATACTCAAACTTTCTGTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008007425	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006188.1

RefSeq Acc Id:	XP_008007425 ⟸ XM_008009234
- UniProtKB:	A0A0D9RC49 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000006188 ⟸ ENSCSAT00000008030

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009976	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008030.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
InterPro	DAZ_repeat	UniProtKB/TrEMBL
	DAZ_RRM_vert	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
NCBI Gene	DAZL	ENTREZGENE
PANTHER	PTHR11176	UniProtKB/TrEMBL
	PTHR11176:SF4	UniProtKB/TrEMBL
Pfam	Daz	UniProtKB/TrEMBL
	RRM_1	UniProtKB/TrEMBL
PROSITE	DAZ	UniProtKB/TrEMBL
	RRM	UniProtKB/TrEMBL
SMART	RRM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	A0A0D9RC49	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-03	DAZL	deleted in azoospermia like	LOC103247129	deleted in azoospermia protein 3-like	Data merged from RGD:18711955	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD