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Gene: RNF186 (ring finger protein 186) Chlorocebus sabaeus

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Symbol:

RNF186

Name:

ring finger protein 186

RGD ID:

18427892

Description:

ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); ubiquitin protein ligase binding (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN regulation of autophagosome assembly (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); chromosome 1p36 deletion syndrome (ortholog); congenital disorder of glycosylation Ir (ortholog); FOUND IN endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

E3 ubiquitin-protein ligase RNF186

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	112,729,333 - 112,732,063 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	112,731,000 - 112,731,683 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	3,448,091 - 3,449,581 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital disorder of glycosylation Ir (ISO)

hyperprolinemia type 2 (ISO)

Parkinson's disease 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (IEA)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein autoubiquitination (IEA)

protein K29-linked ubiquitination (IEA)

protein K63-linked ubiquitination (IEA)

protein localization to mitochondrion (IEA)

regulation of autophagosome assembly (IEA,ISO)

Cellular Component

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

protein binding (ISO)

ubiquitin protein ligase activity (IEA)

ubiquitin protein ligase binding (IEA)

ubiquitin-protein transferase activity (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

RNF186
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	112,729,333 - 112,732,063 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	112,731,000 - 112,731,683 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	3,448,091 - 3,449,581 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

RNF186
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	19,814,029 - 19,815,283 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	19,814,029 - 19,815,283 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	20,140,522 - 20,141,776 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	20,013,109 - 20,014,358 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	18,467,352 - 18,468,601 (-)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	18,386,249 - 18,387,498 (-)	NCBI		HuRef
CHM1_1	1	20,249,753 - 20,251,002 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,637,417 - 19,638,671 (-)	NCBI		T2T-CHM13v2.0

Rnf186
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	138,694,430 - 138,695,676 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	138,694,423 - 138,695,676 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	138,967,119 - 138,968,365 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	138,967,112 - 138,968,360 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	4	138,967,112 - 138,968,365 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	138,523,027 - 138,524,281 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	138,239,280 - 138,240,435 (+)	NCBI		MGSCv36	mm8
Celera	4	140,754,105 - 140,755,357 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.57	NCBI

Rnf186
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,493,750 - 156,494,974 (+)	NCBI		GRCr8
mRatBN7.2	5	151,210,492 - 151,211,716 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,210,492 - 151,211,716 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	153,907,775 - 153,908,999 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	155,682,075 - 155,683,299 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	155,663,993 - 155,665,217 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,416,897 - 157,418,121 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,416,897 - 157,418,121 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	161,156,805 - 161,158,029 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	157,790,446 - 157,791,670 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	149,595,940 - 149,597,164 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Rnf186
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955452	433,413 - 450,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

RNF186
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	207,301,629 - 207,304,516 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	206,418,499 - 206,421,352 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	18,770,083 - 18,772,399 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	19,813,395 - 19,814,638 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	19,813,784 - 19,814,467 (-)	Ensembl	panpan1.1		panPan2

RNF186
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	78,915,131 - 78,916,909 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	78,915,339 - 78,916,037 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	75,427,537 - 75,431,936 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	79,481,271 - 79,488,772 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	79,482,634 - 79,483,332 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	76,299,635 - 76,307,132 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	77,306,635 - 77,314,121 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	78,377,765 - 78,385,273 (+)	NCBI		UU_Cfam_GSD_1.0

Rnf186
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	40,121,950 - 40,123,137 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	5,947,077 - 5,947,772 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF186
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	78,192,337 - 78,198,597 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	78,195,692 - 78,199,058 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Rnf186
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624764	4,897,234 - 4,898,470 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in RNF186
87 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
40	5	17	18	18	39	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007980238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000017896 ⟹ ENSCSAP00000017367

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	112,731,000 - 112,731,683 (+)	Ensembl

RefSeq Acc Id:

XM_007980238 ⟹ XP_007978429

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	112,729,333 - 112,732,063 (+)	NCBI
Vero_WHO_p1.0	NW_023666033	3,448,091 - 3,449,581 (-)	NCBI

Sequence:

show sequence

CTGGGAAAACTGGCTAGCCATATGTAGAAAGCTGAAACTGGATTCCTTCCTTACACCTTATACA
AAGATTTATTTTCCTTTAGCAGAGGTAACTGATGGTCTAGCTACAGGTTGAGAAGAAATGGGAT
GGGATGGTGAGAGAACTGGATTTCAGAGACAGTGGGGGAGGGGTGAGGCAGGAGTTACCCATCC
CACAAGGGAGGGAGCCTCTGTGGGGCTGGCGATTCCAGGACACAGAGGGTGGCCTGCAGTGCCA
GCAACTGGGGCAAGGGAAAGCGCTGAATCAGAGGCACAGGACTCTGTGTGGCCCTTGGCAGGTG
ACATGAGCACCAAAGGATCCTTCACACTGGCTTCTGAGTTCAGAGTGGCCCGAATGAAACATTT
GTTTGAGGGAGTGCACGTGCCCCACCGTCTGCCCTTCAGGGCAAAGTAAGGAAATCACGTTTTC
CTAACTGCTGTGTTGCTAATATCTGCCTGTCCCCACATGAGTCCTGTTAGCCTACGTCACCTGC
CTGGGGCCAGTTGCATCTAAACAAACCAATGAAATTGATTCAATCAGACCTTGGACGCTGGTAG
ATTCCACAAGTTCCTGCCCCATGAAAGGGCCCTCGGCAAGCAGCCAGCAGCCTACCCTGACCAC
ACCCTGCCCTTGTTTCCCAGCCTTCCCTGCAAGGCTGTATCAGGGTTCTGGGAAATGGGGGCTG
GGGACCCCGGGCACAGGGCTTGGCTTAGATAGGCCCAAATAAATGGCAGCTGTTCTTAGTACTA
CTGGATACGCAGCATACCTAGCACACAACAGGACACCTGTGATTAGGCATGTGAAGTGTGCAGC
AGGGCACCGAGTGGAGGCTCATACACCTGTAACTGTGAATACAACAGCTGTGACTCTAAGGAAA
TGAATACAGTAGCAGGTGACAAACACCTGTGCGCTGTATGTGGTTTTATTTTTCTGCATTGGGC
TGGGCTTTGTGCTCCTTCCACTCACTTTTCTACCTCTCCCCTCCTATTCCCAAGGCCACCTGCC
TATAAATGTGTTCCAAGCGCAAACAAACTTTGTTCCACTCATCCTGACATCCAAAAGGTTGTGT
CTGAGAAAGCGGGGTCCCCCAATCCACCTATGTCCGACTCATAGGGTTGTCTGTCAATTGTGCA
GATTTGTAGATGCCAGTGAGCCGAGATCGCGCCACTGCATTCCAACCTGGGTGAGAGAAAGAGA
CTCCGTCTCAAAAAAAAAAAAAAAAAGTTAAATAAAAAAATAAATAAAAGGTTCAGGGACCTGG
GAAGTGGGGGTGAGAGAGTTGGATTCTGATGCATCCCAAAGCTTGAGCCACCCACCAGGCACTT
GGCCCCAACAGGAAAGTCCTGATTCACTAGACCCTGCCCACTTTGCCCTCCTATCAGGCAATTC
AAAGTCTCCAGACCCGCAAGTTACTGATTAACCCTAGGATTTGAGAAAATAAATAATAATAACT
CAAGGGACAACGTAAGCCAAGAAACAAGCTGGGCAGCTCTGGGAAAGAGGAGTCTCAGACAGCT
GTTGTCAACAGGCACCTGGCCAGAGTGAAAAGGAGAGGCAGACTCCATCCAAGTCCCAGCGGCG
CCAGCTGACACTCTCTGCCAATGCCCAGGTGCTGAGCGACAGTGTCCCACTGGTCCCTGTGCCC
AGAATGGCCTGCACCAAGACCCTGCAACAGCCCCAGCCCATCTCCGCAGGAGCCACCACAACCA
CCACCGCTGTGGCTCCCGCTGGGGGTCATCATGGCTCCACAGAATGTGACCTGGAGTGTCTGGT
GTGCCGGGAGCCCTACAGCTGTCCCCGGTCGCCCAAGCTACTGGCCTGCCAGCATGCCTTCTGC
GCCATCTGCCTGAAGCTCCTGCTGTGCGTGCAGGACAACACCTGGTCCATCACCTGCCCACTGT
GCCGCAAGGTCACCACCGTCCCCGGGGGCCTCATCTGCAGCCTGCGCGACCACGAGGCGGTGGT
GAGGCAGCTGGCCCGGTCATGCACAGAGGTGCCGCTCTGTCCTCAGGAGCTGACGGGTCCTACC
GACTTGGCAGCAGGGCACCCCAGCTTGCTAGGAGAGGGTGGACAGGATGAAGTAAGTGCAAACC
ACGTGGCAGCCCGGCGCCTGGCCGCACACCTACTCCTGCTGGCTTTGCTCATCATCCTCATCGG
GCCCTTCATCTACCCGGGTGTCTTACGGTGGGTGCTCACCTTCATCATCGCCCTGGCCCTGCTG
ATGTCCACCCTCTTCTGCTGCCTCCCCAGCAGCCGGGGCAGCTGCTGGCCCTCCTCCAGGACTC
TCTTCTGCAGAGAGCAGAAACACAGCCACATCTCTTCCATTGCCTGAGTGCCCTCTGATGAGGC
TGCCCCTGCGGCCCTTTCTGCCCTTGGGCCCCCGGACTTCCACAATGAACAGGGTAAGGGGTTA
CGGACTAAGACTGGCTCCTTTGGGAAATCACATGCCAGCGGGACTTGCAAGCCAAAGCCGAGAT
GGCCAGCCTGGGTCAAGAATTACACGCTTGGATGACAGGCTTGCACTTGCCCTTGGGATAGCAC
AGCTAAACTGCTGGGAGCTGGGGGAGCAGACACAAACTACTTGAACACGACAAGATGGGGGAAG
CTCTTGTTCCTCTTATGCCAATGTTCCTGGTTTTTCTTTATATAACTTGATGAAAGTATTGCAG
TATTGATGCTATTGTAGAATAGAACTGGAATTCCTTTTTTTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007978429	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017367.1

RefSeq Acc Id:	XP_007978429 ⟸ XM_007980238
- UniProtKB:	A0A0D9S928 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000017367 ⟸ ENSCSAT00000017896

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000639	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017896.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
InterPro	RING_finger_E3_ubiq-ligases	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	csab:103225468	UniProtKB/TrEMBL
NCBI Gene	RNF186	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RNF186	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
PROSITE	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A0D9S928	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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