LRRC53 (leucine rich repeat containing 53) - Rat Genome Database

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Gene: LRRC53 (leucine rich repeat containing 53) Chlorocebus sabaeus
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Symbol: LRRC53
Name: leucine rich repeat containing 53
RGD ID: 18413729
Description: ASSOCIATED WITH Cardiac Conduction Disease with or without Dilated Cardiomyopathy (ortholog); genetic disease (ortholog); FOUND IN plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat-containing protein 53; LOC103224611
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12058,640,427 - 58,693,003 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2058,679,269 - 58,692,748 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603358,755,268 - 58,806,414 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LRRC53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12058,640,427 - 58,693,003 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2058,679,269 - 58,692,748 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603358,755,268 - 58,806,414 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LRRC53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,469,376 - 74,537,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,469,376 - 74,512,611 (-)EnsemblGRCh38hg38GRCh38
GRCh37174,935,060 - 74,978,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p31.1NCBI
CHM1_1175,050,141 - 75,121,397 (-)NCBICHM1_1
T2T-CHM13v2.0174,310,757 - 74,378,470 (-)NCBIT2T-CHM13v2.0
Gm18589
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,543,474 - 154,559,331 (+)NCBIGRCm39GRCm39mm39
GRCm383154,837,837 - 154,853,694 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373154,504,973 - 154,505,551 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera3161,300,209 - 161,300,787 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.32NCBI
Lrrc53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82246,441,139 - 246,467,281 (+)NCBIGRCr8
mRatBN7.22243,781,445 - 243,807,037 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,769,297 - 243,803,164 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02261,058,919 - 261,139,463 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02279,721,709 - 279,818,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2235,649,404 - 235,729,067 (+)NCBICelera
Cytogenetic Map2q45NCBI
Lrrc53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542318,141,159 - 18,204,497 (+)NCBIChiLan1.0ChiLan1.0
LRRC53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21152,366,488 - 152,409,857 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11151,526,925 - 151,569,397 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,698,516 - 73,741,908 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl175,674,245 - 75,687,706 (-)Ensemblpanpan1.1panPan2
LRRC53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha674,552,246 - 74,566,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0672,480,811 - 72,496,551 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1671,974,634 - 71,990,365 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,921,295 - 71,936,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0672,416,208 - 72,431,961 (+)NCBIUU_Cfam_GSD_1.0
Lrrc53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505886,260,241 - 86,280,518 (-)NCBIHiC_Itri_2
Lrrc53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474222,190,672 - 22,208,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
48 9 17 17 17 48 9

Sequence


Ensembl Acc Id: ENSCSAT00000017150   ⟹   ENSCSAP00000016635
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2058,679,269 - 58,692,748 (+)Ensembl
RefSeq Acc Id: XM_007978290   ⟹   XP_007976481
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12058,678,301 - 58,693,003 (+)NCBI
Vero_WHO_p1.0NW_02366603358,755,268 - 58,806,414 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007976481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016635.1
RefSeq Acc Id: XP_007976481   ⟸   XM_007978290
- UniProtKB: A0A0D9S6Z6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000016635   ⟸   ENSCSAT00000017150


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001383 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017150.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRR_TM_domain-containing UniProtKB/TrEMBL
KEGG Report csab:103224611 UniProtKB/TrEMBL
NCBI Gene LOC103224611 ENTREZGENE
PANTHER ANTIGEN BSP, PUTATIVE-RELATED UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT-CONTAINING PROTEIN 53 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A0A0D9S6Z6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LRRC53  leucine rich repeat containing 53  LOC103224611  leucine-rich repeat-containing protein 53  Symbol and/or name change 5135510 APPROVED