TPP2 (tripeptidyl peptidase 2) - Rat Genome Database

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Gene: TPP2 (tripeptidyl peptidase 2) Chlorocebus sabaeus
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Symbol: TPP2
Name: tripeptidyl peptidase 2
RGD ID: 18405073
Description: ENCODES a protein that exhibits identical protein binding (ortholog); peptide binding (ortholog); tripeptidyl-peptidase activity (ortholog); INVOLVED IN intracellular amino acid homeostasis (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); Developmental Disabilities (ortholog); Evans Syndrome, Immunodeficiency, and Premature Immunosenescence associated with Tripeptidyl-Peptidase II Deficiency (ortholog); FOUND IN cytosol (inferred); nuclear body (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tripeptidyl-peptidase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,151,769 - 81,234,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,151,801 - 81,236,235 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604637,688,665 - 37,771,717 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nuclear body  (IEA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,151,769 - 81,234,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,151,801 - 81,236,235 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604637,688,665 - 37,771,717 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,596,986 - 102,679,958 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,596,958 - 102,679,958 (+)EnsemblGRCh38hg38GRCh38
GRCh3713103,249,336 - 103,332,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,047,374 - 102,129,522 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413102,047,373 - 102,129,522NCBI
Celera1384,091,643 - 84,173,864 (+)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1383,841,839 - 83,924,038 (+)NCBIHuRef
CHM1_113103,218,763 - 103,300,981 (+)NCBICHM1_1
T2T-CHM13v2.013101,812,992 - 101,895,917 (+)NCBIT2T-CHM13v2.0
Tpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,973,130 - 44,042,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl143,972,807 - 44,042,160 (+)EnsemblGRCm39 Ensembl
GRCm38143,933,970 - 44,003,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,933,647 - 44,003,000 (+)EnsemblGRCm38mm10GRCm38
MGSCv37143,990,852 - 44,059,816 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36143,878,553 - 43,947,517 (+)NCBIMGSCv36mm8
Celera144,277,065 - 44,346,020 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.5NCBI
Tpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,538,788 - 53,620,253 (+)NCBIGRCr8
mRatBN7.2946,046,712 - 46,128,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,046,632 - 46,128,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,558,681 - 54,643,682 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,681,484 - 59,766,488 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,961,710 - 58,046,719 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,664,048 - 50,744,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0950,578,868 - 50,628,943 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,581,234 - 50,744,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,328,059 - 50,409,442 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0950,244,904 - 50,293,192 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,984,834 - 43,066,195 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,986,247 - 43,067,609 (+)NCBI
Celera943,759,380 - 43,840,712 (+)NCBICelera
Cytogenetic Map9q22NCBI
Tpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,463,715 - 8,528,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554048,465,877 - 8,528,372 (-)NCBIChiLan1.0ChiLan1.0
TPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,113,261 - 104,195,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113102,781,660 - 102,863,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01383,756,757 - 83,838,997 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113102,892,037 - 102,974,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13102,892,037 - 102,974,974 (+)Ensemblpanpan1.1panPan2
TPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,105,821 - 52,176,213 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2252,105,886 - 52,175,426 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2251,885,525 - 51,955,929 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,556,648 - 52,627,124 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,556,638 - 52,627,381 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,205,955 - 52,276,357 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,222,152 - 52,292,574 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,263,035 - 52,333,679 (+)NCBIUU_Cfam_GSD_1.0
Tpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,513,772 - 187,581,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,369,736 - 8,438,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,370,607 - 8,438,376 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1170,943,141 - 71,009,627 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11170,943,142 - 71,009,381 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,219,920 - 78,323,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,779,967 - 8,848,539 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247938,782,956 - 8,848,547 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000015577   ⟹   ENSCSAP00000013514
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl381,151,801 - 81,236,235 (+)Ensembl
RefSeq Acc Id: XM_007960817   ⟹   XP_007959008
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1381,151,769 - 81,234,755 (+)NCBI
Vero_WHO_p1.0NW_02366604637,688,665 - 37,771,717 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007960818   ⟹   XP_007959009
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1381,151,770 - 81,234,755 (+)NCBI
Vero_WHO_p1.0NW_02366604637,688,666 - 37,771,717 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007960820   ⟹   XP_007959011
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1381,151,770 - 81,234,755 (+)NCBI
Vero_WHO_p1.0NW_02366604637,688,666 - 37,771,717 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007960821   ⟹   XP_007959012
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1381,151,770 - 81,234,755 (+)NCBI
Vero_WHO_p1.0NW_02366604637,688,667 - 37,771,717 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007960822   ⟹   XP_007959013
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1381,151,769 - 81,234,755 (+)NCBI
Vero_WHO_p1.0NW_02366604637,688,666 - 37,771,717 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007960823   ⟹   XP_007959014
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1381,151,769 - 81,229,972 (+)NCBI
Vero_WHO_p1.0NW_02366604637,688,665 - 37,766,992 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005243753
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604637,688,666 - 37,771,717 (+)NCBI
RefSeq Acc Id: XR_005243754
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604637,688,666 - 37,771,717 (+)NCBI
RefSeq Acc Id: XP_007959008   ⟸   XM_007960817
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007959013   ⟸   XM_007960822
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007959014   ⟸   XM_007960823
- Peptide Label: isoform X6
RefSeq Acc Id: XP_007959011   ⟸   XM_007960820
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007959009   ⟸   XM_007960818
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007959012   ⟸   XM_007960821
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RY25 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000013514   ⟸   ENSCSAT00000015577


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017483 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015577.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.710 UniProtKB/TrEMBL
  2.60.40.3170 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
  6.10.250.3080 UniProtKB/TrEMBL
InterPro Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-like UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  Peptidase_S8A_TPPII UniProtKB/TrEMBL
  TPP_II_domain UniProtKB/TrEMBL
  TPPII_C_art UniProtKB/TrEMBL
  TPPII_C_sf UniProtKB/TrEMBL
  TPPII_GBD UniProtKB/TrEMBL
  TPPII_Ig-like-1 UniProtKB/TrEMBL
  TPPII_Ig-like_sf UniProtKB/TrEMBL
NCBI Gene TPP2 ENTREZGENE
PANTHER PEPTIDASE S8 UniProtKB/TrEMBL
  TRIPEPTIDYL-PEPTIDASE 2 UniProtKB/TrEMBL
Pfam Peptidase_S8 UniProtKB/TrEMBL
  TPPII UniProtKB/TrEMBL
  TPPII_C UniProtKB/TrEMBL
  TPPII_GBD UniProtKB/TrEMBL
  TPPII_Ig-like-1 UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE SUBTILASE UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
Superfamily-SCOP SSF52743 UniProtKB/TrEMBL
UniProt A0A0D9RY25 ENTREZGENE, UniProtKB/TrEMBL