MMP10 (matrix metallopeptidase 10)

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Gene: MMP10 (matrix metallopeptidase 10) Chlorocebus sabaeus

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Symbol:

MMP10

Name:

matrix metallopeptidase 10

RGD ID:

18395589

Description:

ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase activity (inferred); metallopeptidase activity (inferred); INVOLVED IN regulation of cell migration (ortholog); ASSOCIATED WITH adrenoleukodystrophy (ortholog); asphyxiating thoracic dystrophy (ortholog); asthma (ortholog); FOUND IN extracellular matrix (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

stromelysin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	94,147,995 - 94,158,315 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	94,148,087 - 94,158,097 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	31,719,000 - 31,729,136 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

asphyxiating thoracic dystrophy (ISO)

asthma (ISO)

ataxia telangiectasia (ISO)

contact dermatitis (ISO)

diabetes mellitus (ISO)

end stage renal disease (ISO)

intellectual disability (ISO)

Lung Neoplasms (ISO)

Neoplasm Metastasis (ISO)

rheumatoid arthritis (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

collagen catabolic process (IEA)

extracellular matrix organization (IEA)

proteolysis (IEA)

regulation of cell migration (ISO)

Cellular Component

extracellular matrix (IEA)

Molecular Function

metal ion binding (IEA)

metalloendopeptidase activity (IEA)

metallopeptidase activity (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MMP10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	94,147,995 - 94,158,315 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	94,148,087 - 94,158,097 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	31,719,000 - 31,729,136 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MMP10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	102,770,502 - 102,780,628 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	102,770,502 - 102,780,628 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	102,641,233 - 102,651,359 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	102,146,444 - 102,156,554 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	102,146,443 - 102,156,554	NCBI
Celera	11	99,802,887 - 99,813,014 (-)	NCBI		Celera
Cytogenetic Map	11	q22.2	NCBI
HuRef	11	98,569,206 - 98,579,335 (-)	NCBI		HuRef
CHM1_1	11	102,524,082 - 102,534,205 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	102,774,317 - 102,784,440 (-)	NCBI		T2T-CHM13v2.0

Mmp10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	7,502,343 - 7,510,243 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	7,502,353 - 7,510,241 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	7,502,342 - 7,510,242 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	7,502,352 - 7,510,240 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	7,502,360 - 7,510,240 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	7,490,825 - 7,510,240 (+)	NCBI		MGSCv36	mm8
Celera	9	4,892,709 - 4,900,593 (+)	NCBI		Celera
Cytogenetic Map	9	A1	NCBI
cM Map	9	2.46	NCBI

Mmp10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	12,974,707 - 12,982,613 (+)	NCBI		GRCr8
mRatBN7.2	8	4,689,840 - 4,697,748 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	4,689,840 - 4,697,748 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	8,649,536 - 8,657,457 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	6,947,308 - 6,955,231 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	4,949,505 - 4,957,411 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	5,734,348 - 5,742,243 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	5,734,348 - 5,742,243 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	5,737,196 - 5,745,091 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	4,367,842 - 4,375,737 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	4,367,841 - 4,375,737 (+)	NCBI
Celera	8	6,249,460 - 6,257,355 (+)	NCBI		Celera
Cytogenetic Map	8	q11	NCBI

Mmp10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	5,965,394 - 5,976,382 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	5,965,388 - 5,976,353 (-)	NCBI	ChiLan1.0	ChiLan1.0

MMP10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	103,563,643 - 103,574,074 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	104,651,805 - 104,662,248 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	97,710,819 - 97,721,263 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	101,201,665 - 101,212,103 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	101,201,665 - 101,212,103 (-)	Ensembl	panpan1.1		panPan2

Mmp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	86,338,808 - 86,348,136 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936551	5,188,395 - 5,197,477 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Mmp10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624878	107,361 - 117,459 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624878	107,330 - 117,654 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
29	3	20	22	22	27	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008020658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000001229 ⟹ ENSCSAP00000014844

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	1	94,148,087 - 94,158,097 (-)	Ensembl

RefSeq Acc Id:

XM_008020658 ⟹ XP_008018849

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	1	94,147,995 - 94,158,315 (-)	NCBI
Vero_WHO_p1.0	NW_023666043	31,719,000 - 31,729,136 (+)	NCBI

Sequence:

show sequence

TCCTGGGGATTAATCATTCTTTCAAGTTTAGAATGTTGAAGGAAAATACCAATGTAGGCTGTAT
CACCATTACATTAAAAGTTTGTGAGCATTCAGACTTAAAAAACATATGCATGAATCATGCTGTT
GGTGACCTAAGCATTGTCTCTGTATAAAAGAAAGGACACTAGGGGGTAGAGCTAGAAGCCCAGT
AGACAGAGAAGATAAGGACAGTGAGAATGATGCATCTTGCATTCCTCGTGCTGTTGTGTCTGCC
AGTCTGCTCTGCCTATCCTCTGAGTGGGGCAGCAAAACAGGAGGACTCCAACAGGGATCTTGCC
CAGCAATACCTAGAAAACTACTACAACCTCAAAACAGATGTGAAACAGTTTAGAAGAAAGGAGA
GTAATCTCATTGTTAAAAAAATCCAACGAATGCAGAAGTTCCTTGGGTTGGCAGCAACAGGGAA
GCTGGACTCTGACACTCTGGAGGTGATGCGCAAGCCCAGGTGTGGAGTTCCTGACGTTGGTCAC
TTCACAACGTTTCCTGGCATCCCGAAGTGGAGGAAAACCCACCTTACATACAGGATTGTGAATT
ATACACCAGATTTGCCAAGAGATGCTGTTGATTCTGCCGTTGAGAAAGCTGTGAAAGTCTGGGA
AGAGGTGACTCCACTCACTTTCTCTAGGCTGTATGAAGGAGAAGCTGATATAATGATCTCTTTT
GCAGTTAAAGAACATGGAGACTTTTACTCTTTTGATGGCTCAGGACAGAGCTTGGCTCATGCCT
ATCCACCTGGACCTGGGTTTTATGGAGATATCCACTTTGATGATGATGAAAAATGGACAGAAGA
TGCATCAGGCACCAATTTATTCCTCGTTGCTGCTCATGAACTTGGCCACTCCCTGGGGCTCTTT
CACTCAGCCAACACTGAAGCTTTGATGTACCCACTCTACAACTCATTCACAGAGCTGGCCCGGT
TCCGCCTTTCACAAGATGATGTGAATGGCATTCAGTCTCTCTATGGATCTCCCCCTGCCTCTAC
TGAGGAACCCCTGGTGTCCACAAAATCCGTCCCTTCAGGATCTGGGACGCCAGCCAAGTGTGAC
CCTGCTTTGTCCTTCGATGCCATCAGCACTCTGAGGGGAGAATATCTGTTCTTTAAAGACAGAT
ATTTTTGGCGAAGATCCCACTGGAACTCTGAACCTGAATTTCATTTGATTTCTACATTTTGGCC
CTCTCTCCCGTCATATTTGGATGCTGCATATGAAGTTAATAGCAGGGATACAGTTTTTATTTTT
AAAGGAAATGAGTTCTGGGCCATCAGAGGAAATGAGGTACAAGCGGGTTACCCAAGAGGTATCC
ATACCCTGGGTTTTCCTCCAACCATAAGGAAAATTGATGCAGCTGTTTCTGACAAGGAAAAGAA
GAAAACATACTTCTTTGTAGAGGACAAATACTGGAGATTTGATGAAAATAGCCAGTCCATGGAA
CAAGGCTTCCCTAGACTAATAGCTGATGACTTTCCAGGAGTTGAACCTAAGGTCGATGCGGTAT
TACAGGCATTTGGATTTTTCTATTTCTTCAGTGGATCATCACAGTTTGAGTTTGACCCCAATGC
CAGGATGGTGACACGCATACTGAAGAGTAACAGCTGGTTACATTGCTAGACAAGATAGGGGGAA
AACTGATATGGGTGTTTTAAATAAATCTAATAATTATTCATCTAATGTATTATGAGCCAAAATG
ATTAATTTTTCCTGCATGTTCTATGGTTAAAGAAGAGGAGTCTTGCAGACATCTGTATGTGTCA
TGAAGAATGTTTCTGGAATGCTTCGTTTGCTTTTGAATTACATTCAACAGAATTAAGAAATACT
CATGTGCAATAGGTGAAAGAATGTATTTTCATAGATGTTTTATTACTTCTTCAATAAAAAAGTA
TTTTATTTTGGGCCTGTTCCTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008018849	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000014844.1

RefSeq Acc Id:	XP_008018849 ⟸ XM_008020658
- UniProtKB:	A0A0D9S1V5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000014844 ⟸ ENSCSAT00000001229

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000003203	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000001229.1	UniProtKB/TrEMBL
Gene3D-CATH	2.110.10.10	UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/TrEMBL
InterPro	Hemopexin-like_dom	UniProtKB/TrEMBL
	Hemopexin-like_dom_sf	UniProtKB/TrEMBL
	Hemopexin-like_repeat	UniProtKB/TrEMBL
	Hemopexin_CS	UniProtKB/TrEMBL
	M10A_MMP	UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/TrEMBL
	Pept_M10_metallopeptidase	UniProtKB/TrEMBL
	Pept_M10A	UniProtKB/TrEMBL
	Pept_M10A_Zn_BS	UniProtKB/TrEMBL
	Peptidase_Metallo	UniProtKB/TrEMBL
	Peptidoglycan-bd-like	UniProtKB/TrEMBL
	PGBD-like_sf	UniProtKB/TrEMBL
KEGG Report	csab:103248336	UniProtKB/TrEMBL
NCBI Gene	MMP10	ENTREZGENE
PANTHER	MATRIX METALLOPROTEINASE	UniProtKB/TrEMBL
	STROMELYSIN-2	UniProtKB/TrEMBL
Pfam	Hemopexin	UniProtKB/TrEMBL
	Peptidase_M10	UniProtKB/TrEMBL
	PG_binding_1	UniProtKB/TrEMBL
PIRSF	Peptidase_M10A_matrix	UniProtKB/TrEMBL
PRINTS	MATRIXIN	UniProtKB/TrEMBL
PROSITE	CYSTEINE_SWITCH	UniProtKB/TrEMBL
	HEMOPEXIN	UniProtKB/TrEMBL
	HEMOPEXIN_2	UniProtKB/TrEMBL
SMART	SM00120	UniProtKB/TrEMBL
	ZnMc	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	SSF47090	UniProtKB/TrEMBL
	SSF50923	UniProtKB/TrEMBL
UniProt	A0A0D9S1V5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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