Defb3 (defensin beta 3) - Rat Genome Database

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Gene: Defb3 (defensin beta 3) Mus musculus
Analyze
Symbol: Defb3
Name: defensin beta 3
RGD ID: 1624054
MGI Page MGI
Description: Predicted to enable CCR6 chemokine receptor binding activity; chemoattractant activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in skin. Orthologous to human DEFB4A (defensin beta 4A) and DEFB4B (defensin beta 4B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-3; beta-defensin 3; defensin, beta 3; mBD-3; MGC129397
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39819,343,377 - 19,345,355 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl819,343,376 - 19,345,307 (+)EnsemblGRCm39 Ensembl
GRCm38819,293,361 - 19,295,339 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl819,293,360 - 19,295,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv37819,293,361 - 19,295,339 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36819,293,341 - 19,295,316 (+)NCBIMGSCv36mm8
Celera819,417,528 - 19,419,519 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10377137   PMID:10922379   PMID:11408484   PMID:12226710   PMID:12466851   PMID:12477932   PMID:12644567   PMID:15102787   PMID:16897670   PMID:17116754   PMID:17874048   PMID:18699806  
PMID:18925411   PMID:19301094   PMID:19933858   PMID:20003482   PMID:20223839   PMID:20337925   PMID:20930145   PMID:21039426   PMID:21115716   PMID:21873635   PMID:22418431   PMID:23499548  
PMID:23670560   PMID:24532508   PMID:26317211   PMID:26438362   PMID:27923704   PMID:28647345   PMID:29925780   PMID:35241668   PMID:37464450   PMID:37725983  


Genomics

Comparative Map Data
Defb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39819,343,377 - 19,345,355 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl819,343,376 - 19,345,307 (+)EnsemblGRCm39 Ensembl
GRCm38819,293,361 - 19,295,339 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl819,293,360 - 19,295,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv37819,293,361 - 19,295,339 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36819,293,341 - 19,295,316 (+)NCBIMGSCv36mm8
Celera819,417,528 - 19,419,519 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.35NCBI
DEFB4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,894,677 - 7,896,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,894,677 - 7,896,716 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl87,414,855 - 7,416,863 (-)EnsemblGRCh38hg38GRCh38
GRCh3787,752,199 - 7,754,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,789,609 - 7,791,647 (+)NCBINCBI36Build 36hg18NCBI36
Build 3487,789,608 - 7,791,647NCBI
Cytogenetic Map8p23.1NCBI
CHM1_187,817,857 - 7,819,910 (+)NCBICHM1_1
T2T-CHM13v2.0812,040,687 - 12,042,691 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Defb3
145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:98
Interacting mature miRNAs:99
Transcripts:ENSMUST00000033852
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
Defb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38819,295,119 - 19,295,338UniSTSGRCm38
MGSCv37819,295,119 - 19,295,338UniSTSGRCm37
Celera819,419,299 - 19,419,518UniSTS
cM Map8 UniSTS
UniSTS:487779  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38819,523,738 - 19,525,157UniSTSGRCm38
MGSCv37819,523,738 - 19,525,157UniSTSGRCm37
Celera819,688,326 - 19,689,740UniSTS
Cytogenetic Map8A1.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000033852   ⟹   ENSMUSP00000033852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl819,343,376 - 19,345,307 (+)Ensembl
GRCm38.p6 Ensembl819,293,360 - 19,295,291 (+)Ensembl
RefSeq Acc Id: NM_013756   ⟹   NP_038784
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,343,377 - 19,345,355 (+)NCBI
GRCm38819,293,361 - 19,295,339 (+)ENTREZGENE
MGSCv37819,293,361 - 19,295,339 (+)RGD
Celera819,417,528 - 19,419,519 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_038784   ⟸   NM_013756
- Peptide Label: precursor
- UniProtKB: Q29R78 (UniProtKB/Swiss-Prot),   Q9WTL0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000033852   ⟸   ENSMUST00000033852

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTL0-F1-model_v2 AlphaFold Q9WTL0 1-63 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351612 AgrOrtholog
Ensembl Genes ENSMUSG00000039775 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033852 ENTREZGENE
  ENSMUST00000033852.8 UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot
KEGG Report mmu:27358 UniProtKB/Swiss-Prot
MGD MGI:1351612 ENTREZGENE
NCBI Gene 27358 ENTREZGENE
PANTHER BETA-DEFENSIN UniProtKB/Swiss-Prot
  BETA-DEFENSIN 3-RELATED UniProtKB/Swiss-Prot
Pfam Defensin_beta UniProtKB/Swiss-Prot
PhenoGen Defb3 PhenoGen
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot
UniProt DEFB3_MOUSE UniProtKB/Swiss-Prot
  Q29R78 ENTREZGENE
  Q9WTL0 ENTREZGENE
UniProt Secondary Q29R78 UniProtKB/Swiss-Prot