Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hexd | Mouse | 17beta-estradiol | increases expression | ISO | HEXD (Homo sapiens) | 6480464 | Estradiol results in increased expression of HEXD mRNA | CTD | PMID:23019147 | Hexd | Mouse | 17beta-estradiol | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | Estradiol results in decreased expression of HEXD mRNA | CTD | PMID:31614463 | Hexd | Mouse | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | Hexd | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HEXD mRNA | CTD | PMID:21570461 | Hexd | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Hexd (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HEXD mRNA | CTD | PMID:33387578 | Hexd | Mouse | 6-propyl-2-thiouracil | increases expression | ISO | Hexd (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of HEXD mRNA | CTD | PMID:24780913 | Hexd | Mouse | acrylamide | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of HEXD mRNA | CTD | PMID:32763439 | Hexd | Mouse | aflatoxin B1 | increases methylation | ISO | HEXD (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of HEXD intron | CTD | PMID:30157460 | Hexd | Mouse | antirheumatic drug | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of HEXD mRNA | CTD | PMID:24449571 | Hexd | Mouse | atrazine | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | Atrazine results in decreased expression of HEXD mRNA | CTD | PMID:22378314 | Hexd | Mouse | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of HEXD mRNA] | CTD | PMID:22228805 | Hexd | Mouse | bisphenol A | increases expression | ISO | Hexd (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of HEXD mRNA | CTD | PMID:25181051 and PMID:34947998 | Hexd | Mouse | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of HEXD promoter | CTD | PMID:27312807 | Hexd | Mouse | bisphenol A | affects splicing | EXP | | 6480464 | bisphenol A affects the splicing of HEXD mRNA | CTD | PMID:37894381 | Hexd | Mouse | bisphenol A | decreases methylation | ISO | HEXD (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of HEXD gene | CTD | PMID:31601247 | Hexd | Mouse | bisphenol A | increases methylation | ISO | Hexd (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of HEXD gene | CTD | PMID:28505145 | Hexd | Mouse | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of HEXD mRNA | CTD | PMID:38685157 | Hexd | Mouse | bortezomib | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | Bortezomib results in decreased expression of HEXD mRNA | CTD | PMID:20977926 | Hexd | Mouse | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of HEXD mRNA | CTD | PMID:28472532 | Hexd | Mouse | copper(II) sulfate | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of HEXD mRNA | CTD | PMID:19549813 | Hexd | Mouse | Dibutyl phosphate | affects expression | ISO | HEXD (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of HEXDC mRNA | CTD | PMID:37042841 | Hexd | Mouse | dorsomorphin | multiple interactions | ISO | HEXD (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEXD mRNA | CTD | PMID:27188386 | Hexd | Mouse | genistein | increases expression | ISO | HEXD (Homo sapiens) | 6480464 | Genistein results in increased expression of HEXD mRNA | CTD | PMID:23019147 | Hexd | Mouse | gentamycin | increases expression | ISO | Hexd (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of HEXD mRNA | CTD | PMID:33387578 | Hexd | Mouse | hypochlorous acid | decreases expression | EXP | | 6480464 | Hypochlorous Acid results in decreased expression of HEXD mRNA | CTD | PMID:19376150 | Hexd | Mouse | inulin | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HEXD mRNA | CTD | PMID:36331819 | Hexd | Mouse | iron dichloride | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of HEXD mRNA | CTD | PMID:35984750 | Hexd | Mouse | manganese atom | multiple interactions | EXP | | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HEXD mRNA | CTD | PMID:35690225 | Hexd | Mouse | manganese(0) | multiple interactions | EXP | | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HEXD mRNA | CTD | PMID:35690225 | Hexd | Mouse | manganese(II) chloride | multiple interactions | EXP | | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HEXD mRNA | CTD | PMID:35690225 | Hexd | Mouse | paracetamol | increases expression | ISO | Hexd (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of HEXD mRNA | CTD | PMID:33387578 | Hexd | Mouse | PCB138 | decreases expression | ISO | Hexd (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:23829299 | Hexd | Mouse | perfluorohexanesulfonic acid | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of HEXD mRNA | CTD | PMID:25812627 | Hexd | Mouse | perfluorononanoic acid | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of HEXD mRNA | CTD | PMID:25812627 | Hexd | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HEXD mRNA | CTD | PMID:36331819 | Hexd | Mouse | perfluorooctane-1-sulfonic acid | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of HEXD mRNA | CTD | PMID:25812627 | Hexd | Mouse | perfluorooctanoic acid | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of HEXD mRNA | CTD | PMID:25812627 | Hexd | Mouse | phenylmercury acetate | multiple interactions | ISO | HEXD (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEXD mRNA | CTD | PMID:27188386 | Hexd | Mouse | SB 431542 | multiple interactions | ISO | HEXD (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEXD mRNA | CTD | PMID:27188386 | Hexd | Mouse | sodium arsenite | decreases expression | ISO | HEXD (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of HEXD mRNA | CTD | PMID:38568856 | Hexd | Mouse | sunitinib | increases expression | ISO | HEXD (Homo sapiens) | 6480464 | Sunitinib results in increased expression of HEXD mRNA | CTD | PMID:31533062 | Hexd | Mouse | temozolomide | increases expression | ISO | HEXD (Homo sapiens) | 6480464 | Temozolomide results in increased expression of HEXD mRNA | CTD | PMID:31758290 | Hexd | Mouse | thioacetamide | decreases expression | ISO | Hexd (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of HEXD mRNA | CTD | PMID:34492290 | Hexd | Mouse | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of HEXD mRNA | CTD | PMID:29264374 | Hexd | Mouse | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of HEXD mRNA | CTD | PMID:33045310 | Hexd | Mouse | troglitazone | decreases expression | EXP | | 6480464 | Troglitazone results in decreased expression of HEXD mRNA | CTD | PMID:28973697 | Hexd | Mouse | valproic acid | affects expression | ISO | HEXD (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HEXD mRNA | CTD | PMID:25979313 | Hexd | Mouse | valproic acid | increases methylation | ISO | HEXD (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of HEXD gene | CTD | PMID:29154799 | Hexd | Mouse | vinclozolin | affects expression | ISO | Hexd (Rattus norvegicus) | 6480464 | vinclozolin affects the expression of HEXD mRNA | CTD | PMID:23034163 | |