Spink14 (serine peptidase inhibitor, Kazal type 14) - Rat Genome Database

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Gene: Spink14 (serine peptidase inhibitor, Kazal type 14) Mus musculus
Analyze
Symbol: Spink14
Name: serine peptidase inhibitor, Kazal type 14
RGD ID: 1621892
MGI Page MGI
Description: Orthologous to human SPINK14 (serine peptidase inhibitor Kazal type 14 (putative)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG433178; Gm5505; Kazal type serine protease inhibitor 5-like 2; serine protease inhibitor Kazal-type 14
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,160,936 - 44,165,275 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,160,936 - 44,165,484 (+)EnsemblGRCm39 Ensembl
GRCm381844,027,869 - 44,032,208 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,027,869 - 44,032,417 (+)EnsemblGRCm38mm10GRCm38
MGSCv371844,187,523 - 44,191,862 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,153,792 - 44,157,748 (+)NCBIMGSCv36mm8
Celera1845,404,003 - 45,408,310 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21677750   PMID:30973865   PMID:38355793  


Genomics

Comparative Map Data
Spink14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,160,936 - 44,165,275 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,160,936 - 44,165,484 (+)EnsemblGRCm39 Ensembl
GRCm381844,027,869 - 44,032,208 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,027,869 - 44,032,417 (+)EnsemblGRCm38mm10GRCm38
MGSCv371844,187,523 - 44,191,862 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,153,792 - 44,157,748 (+)NCBIMGSCv36mm8
Celera1845,404,003 - 45,408,310 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
SPINK14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385148,168,546 - 148,175,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5148,168,546 - 148,175,619 (+)EnsemblGRCh38hg38GRCh38
GRCh375147,548,109 - 147,555,182 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,529,489 - 147,535,154 (+)NCBINCBI36Build 36hg18NCBI36
Celera5143,630,039 - 143,634,356 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,696,417 - 142,702,136 (+)NCBIHuRef
CHM1_15146,981,715 - 146,987,380 (+)NCBICHM1_1
T2T-CHM13v2.05148,704,264 - 148,709,980 (+)NCBIT2T-CHM13v2.0
Spink14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,589,158 - 36,593,309 (+)NCBIGRCr8
mRatBN7.21836,339,223 - 36,341,261 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,339,223 - 36,342,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,443,247 - 36,445,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,161,597 - 37,163,635 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,538,498 - 36,540,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01229,349,133 - 229,351,168 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,196,537 - 35,199,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl236,011,045 - 36,013,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1229,349,133 - 229,351,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01236,506,634 - 236,508,669 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,638,618 - 37,641,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11837,673,883 - 37,676,805 (+)NCBI
Cytogenetic Map18q11NCBI
SPINK14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,402,557 - 143,408,579 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,542,107 - 141,548,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,598,502 - 143,604,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,606,819 - 149,612,784 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5149,606,819 - 149,612,784 (+)Ensemblpanpan1.1panPan2
SPINK14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,388,792 - 42,393,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,388,311 - 42,393,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,431,445 - 39,439,229 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,845,240 - 42,853,022 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,849,693 - 42,853,029 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,915,223 - 39,923,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,725,232 - 40,733,013 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,548,458 - 41,556,244 (+)NCBIUU_Cfam_GSD_1.0
Spink14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,061,304 - 145,064,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365046,635,277 - 6,638,296 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365046,635,277 - 6,638,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,415,857 - 149,424,227 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,414,615 - 149,423,473 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,181,121 - 156,189,865 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603427,059,376 - 27,066,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247747,596,610 - 7,600,661 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink14
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:51
Interacting mature miRNAs:52
Transcripts:ENSMUST00000060328, ENSMUST00000162265
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
10412262Gre1_mGlucocorticoid receptor expression 1 (mouse)Not determined184354107846536999Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000060328   ⟹   ENSMUSP00000057781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,160,936 - 44,165,275 (+)Ensembl
GRCm38.p6 Ensembl1844,027,869 - 44,032,208 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162265   ⟹   ENSMUSP00000125319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,161,761 - 44,165,275 (+)Ensembl
GRCm38.p6 Ensembl1844,028,694 - 44,032,208 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237843
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1844,161,528 - 44,165,484 (+)Ensembl
GRCm38.p6 Ensembl1844,028,461 - 44,032,417 (+)Ensembl
RefSeq Acc Id: NM_001039218   ⟹   NP_001034307
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391844,160,936 - 44,165,275 (+)NCBI
GRCm381844,027,869 - 44,032,208 (+)ENTREZGENE
MGSCv371844,187,523 - 44,191,862 (+)RGD
Celera1845,404,003 - 45,408,310 (+)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001034307 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI47449 (Get FASTA)   NCBI Sequence Viewer  
  AAI47477 (Get FASTA)   NCBI Sequence Viewer  
  BAC29624 (Get FASTA)   NCBI Sequence Viewer  
  EDL10006 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000057781
  ENSMUSP00000057781.3
  ENSMUSP00000125319.2
RefSeq Acc Id: NP_001034307   ⟸   NM_001039218
- Peptide Label: precursor
- UniProtKB: B9EJP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000057781   ⟸   ENSMUST00000060328
Ensembl Acc Id: ENSMUSP00000125319   ⟸   ENSMUST00000162265
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B9EJP9-F1-model_v2 AlphaFold B9EJP9 1-96 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3646952 AgrOrtholog
Ensembl Genes ENSMUSG00000051050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000060328 ENTREZGENE
  ENSMUST00000060328.9 UniProtKB/TrEMBL
  ENSMUST00000162265.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
InterPro Kazal-type_SerProtInhib UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  Prot_inh_Kazal UniProtKB/TrEMBL
KEGG Report mmu:433178 UniProtKB/TrEMBL
MGD MGI:3646952 ENTREZGENE
NCBI Gene 433178 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR KAZAL-TYPE 14 UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 UniProtKB/TrEMBL
Pfam Kazal_1 UniProtKB/TrEMBL
PhenoGen Spink14 PhenoGen
PROSITE KAZAL_1 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
SMART KAZAL UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
UniProt B9EJP9 ENTREZGENE, UniProtKB/TrEMBL
  Q8CB33_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Spink14  serine peptidase inhibitor, Kazal type 14  Gm5505  predicted gene 5505  Symbol and/or name change 5135510 APPROVED