Gstt4 (glutathione S-transferase, theta 4) - Rat Genome Database

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Gene: Gstt4 (glutathione S-transferase, theta 4) Mus musculus
Analyze
Symbol: Gstt4
Name: glutathione S-transferase, theta 4
RGD ID: 1620724
MGI Page MGI
Description: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Orthologous to human GSTT4 (glutathione S-transferase theta 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930583C14Rik; AI507011; glutathione S-transferase theta-4; GST class-theta-4
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,650,777 - 75,658,405 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,650,777 - 75,658,377 (-)EnsemblGRCm39 Ensembl
GRCm381075,814,943 - 75,822,566 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,814,943 - 75,822,543 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,277,688 - 75,285,288 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,258,662 - 75,266,236 (-)NCBIMGSCv36mm8
Celera1076,859,618 - 76,867,219 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:20096683   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Gstt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,650,777 - 75,658,405 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,650,777 - 75,658,377 (-)EnsemblGRCm39 Ensembl
GRCm381075,814,943 - 75,822,566 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,814,943 - 75,822,543 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,277,688 - 75,285,288 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,258,662 - 75,266,236 (-)NCBIMGSCv36mm8
Celera1076,859,618 - 76,867,219 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.58NCBI
GSTT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,989,115 - 24,005,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,998,401 - 24,005,453 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,340,595 - 24,347,350 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,670,595 - 22,677,258 (-)NCBINCBI36Build 36hg18NCBI36
Celera228,141,156 - 8,147,155 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,288,707 - 7,295,363 (-)NCBIHuRef
CHM1_12224,353,110 - 24,360,070 (-)NCBICHM1_1
T2T-CHM13v2.02224,405,779 - 24,412,527 (-)NCBIT2T-CHM13v2.0
Gstt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,834,613 - 12,841,730 (+)NCBIGRCr8
mRatBN7.22012,835,178 - 12,842,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,835,178 - 12,842,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,541,554 - 13,548,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,902,481 - 12,909,800 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,374,423 - 13,381,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,778,185 - 13,784,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,778,178 - 13,784,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,968,093 - 15,975,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,238,379 - 13,239,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2014,326,728 - 14,333,740 (+)NCBICelera
Cytogenetic Map20p12NCBI
LOC486404
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,553,498 - 28,564,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,626,825 - 27,637,840 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,959,598 - 29,970,333 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,930,214 - 30,010,240 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,040,792 - 28,052,080 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,657,366 - 27,668,529 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,647,138 - 28,658,218 (-)NCBIUU_Cfam_GSD_1.0
GSTT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,812,019 - 49,819,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,812,009 - 49,819,028 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,254,244 - 53,261,383 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Gstt4
170 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:320
Count of miRNA genes:250
Interacting mature miRNAs:260
Transcripts:ENSMUST00000159241, ENSMUST00000160211
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse

Markers in Region
AI507011  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381075,815,008 - 75,815,140UniSTSGRCm38
MGSCv371075,277,753 - 75,277,885UniSTSGRCm37
Celera1076,859,683 - 76,859,815UniSTS
Cytogenetic Map10C1UniSTS
Whitehead/MRC_RH10864.38UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000159241   ⟹   ENSMUSP00000124989
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1075,650,778 - 75,658,361 (-)Ensembl
GRCm38.p6 Ensembl1075,814,944 - 75,822,527 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160211   ⟹   ENSMUSP00000125604
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1075,650,777 - 75,658,377 (-)Ensembl
GRCm38.p6 Ensembl1075,814,943 - 75,822,543 (-)Ensembl
RefSeq Acc Id: NM_029472   ⟹   NP_083748
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391075,650,777 - 75,658,377 (-)NCBI
GRCm381075,814,943 - 75,822,543 (-)NCBI
MGSCv371075,277,688 - 75,285,288 (-)RGD
Celera1076,859,618 - 76,867,219 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514271   ⟹   XP_006514334
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391075,650,777 - 75,658,397 (-)NCBI
GRCm381075,814,943 - 75,822,563 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245345   ⟹   XP_030101205
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391075,650,777 - 75,658,400 (-)NCBI
GRCm381075,814,943 - 75,822,566 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156070   ⟹   XP_036011963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391075,655,827 - 75,658,405 (-)NCBI
Sequence:
RefSeq Acc Id: NP_083748   ⟸   NM_029472
- UniProtKB: Q9D4P7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006514334   ⟸   XM_006514271
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030101205   ⟸   XM_030245345
- Peptide Label: isoform X3
Ensembl Acc Id: ENSMUSP00000124989   ⟸   ENSMUST00000159241
Ensembl Acc Id: ENSMUSP00000125604   ⟸   ENSMUST00000160211
RefSeq Acc Id: XP_036011963   ⟸   XM_036156070
- Peptide Label: isoform X2
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D4P7-F1-model_v2 AlphaFold Q9D4P7 1-240 view protein structure

Promoters
RGD ID:8672336
Promoter ID:EPDNEW_M14199
Type:initiation region
Name:Gstt4_1
Description:Mus musculus glutathione S-transferase, theta 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381075,822,527 - 75,822,587EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923136 AgrOrtholog
Ensembl Genes ENSMUSG00000009093 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000159241.2 UniProtKB/TrEMBL
  ENSMUST00000160211 ENTREZGENE
  ENSMUST00000160211.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot
  GST_C_Theta UniProtKB/Swiss-Prot
  GST_N_Theta UniProtKB/Swiss-Prot
  GST_Theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:75886 UniProtKB/Swiss-Prot
MGD MGI:1923136 ENTREZGENE
NCBI Gene 75886 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE THETA-4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43917 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N_3 UniProtKB/Swiss-Prot
PhenoGen Gstt4 PhenoGen
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PVU4_MOUSE UniProtKB/TrEMBL
  GSTT4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE