Vash1 (vasohibin 1) - Rat Genome Database

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Gene: Vash1 (vasohibin 1) Mus musculus
Analyze
Symbol: Vash1
Name: vasohibin 1
RGD ID: 1620582
MGI Page MGI
Description: Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development and negative regulation of angiogenesis. Predicted to be located in apical part of cell; endoplasmic reticulum; and extracellular space. Predicted to be active in cytoplasm. Is expressed in nervous system and retina. Human ortholog(s) of this gene implicated in liver cirrhosis and portal hypertension. Orthologous to human VASH1 (vasohibin 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI834978; D930046M13Rik; G630009D10Rik; RIKEN cDNA D930046M13 gene; TTCP 1; tubulinyl-Tyr carboxypeptidase 1; tyrosine carboxypeptidase 1; vasohibin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391286,725,474 - 86,742,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1286,725,474 - 86,738,865 (+)EnsemblGRCm39 Ensembl
GRCm381286,678,700 - 86,695,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1286,678,700 - 86,692,091 (+)EnsemblGRCm38mm10GRCm38
MGSCv371288,019,650 - 88,036,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361287,567,803 - 87,581,194 (+)NCBIMGSCv36mm8
Celera1288,140,378 - 88,157,636 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1240.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats. Coch L, etal., Hepatology. 2014 Aug;60(2):633-47. doi: 10.1002/hep.26995. Epub 2014 Jun 18.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:15467828   PMID:16141072   PMID:16141073   PMID:16473886  
PMID:16528006   PMID:16707096   PMID:19179360   PMID:19204325   PMID:19498005   PMID:19682397   PMID:20133819   PMID:20884873   PMID:21228103   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:23056314   PMID:24066086   PMID:25184477   PMID:25255225   PMID:26025651   PMID:26410627   PMID:27169581   PMID:27325558   PMID:29146868   PMID:31091125   PMID:31815666   PMID:32325033  
PMID:32560809   PMID:33441910   PMID:34321999   PMID:35180473  


Genomics

Comparative Map Data
Vash1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391286,725,474 - 86,742,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1286,725,474 - 86,738,865 (+)EnsemblGRCm39 Ensembl
GRCm381286,678,700 - 86,695,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1286,678,700 - 86,692,091 (+)EnsemblGRCm38mm10GRCm38
MGSCv371288,019,650 - 88,036,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361287,567,803 - 87,581,194 (+)NCBIMGSCv36mm8
Celera1288,140,378 - 88,157,636 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1240.84NCBI
VASH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381476,761,468 - 76,783,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1476,761,468 - 76,783,015 (+)EnsemblGRCh38hg38GRCh38
GRCh371477,227,811 - 77,249,358 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361476,298,285 - 76,319,111 (+)NCBINCBI36Build 36hg18NCBI36
Build 341476,298,284 - 76,319,109NCBI
Celera1457,266,828 - 57,287,976 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1457,396,835 - 57,417,983 (+)NCBIHuRef
CHM1_11477,166,049 - 77,187,187 (+)NCBICHM1_1
T2T-CHM13v2.01470,970,762 - 70,992,327 (+)NCBIT2T-CHM13v2.0
Vash1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,060,086 - 112,076,689 (+)NCBIGRCr8
mRatBN7.26106,330,374 - 106,345,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,329,123 - 106,345,726 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.06110,624,377 - 110,640,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6110,624,856 - 110,637,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06119,921,674 - 119,938,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46110,806,294 - 110,818,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6104,151,889 - 104,168,420 (+)NCBICelera
Cytogenetic Map6q31NCBI
Vash1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955438752,554 - 772,937 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955438753,392 - 772,937 (+)NCBIChiLan1.0ChiLan1.0
VASH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21577,846,765 - 77,868,086 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,063,264 - 77,084,593 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01457,315,866 - 57,337,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11476,522,881 - 76,544,254 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1476,522,881 - 76,544,251 (+)Ensemblpanpan1.1panPan2
VASH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1849,631,029 - 49,651,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl849,631,910 - 49,648,168 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,314,932 - 49,335,554 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0849,857,895 - 49,878,478 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl849,858,702 - 49,881,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1849,528,855 - 49,548,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0849,551,007 - 49,571,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0849,949,126 - 49,969,713 (+)NCBIUU_Cfam_GSD_1.0
Vash1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864026,372,770 - 26,393,180 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364885,675,782 - 5,696,222 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364885,675,788 - 5,696,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VASH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl799,910,497 - 99,929,770 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1799,910,644 - 99,933,633 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27105,958,917 - 105,978,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VASH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,025,548 - 54,047,122 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2454,026,617 - 54,047,135 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605342,224,646 - 42,246,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vash1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473425,034,266 - 25,053,398 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473425,034,266 - 25,053,409 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vash1
488 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:204
Interacting mature miRNAs:220
Transcripts:ENSMUST00000021681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
AI834978  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381286,695,515 - 86,695,598UniSTSGRCm38
GRCm38596,319,092 - 96,319,176UniSTSGRCm38
MGSCv371288,036,465 - 88,036,548UniSTSGRCm37
MGSCv37596,748,111 - 96,748,195UniSTSGRCm37
Celera1288,157,470 - 88,157,553UniSTS
Celera593,658,295 - 93,658,379UniSTS
Cytogenetic Map12D2UniSTS
Whitehead/MRC_RH12817.98UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000021681   ⟹   ENSMUSP00000021681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1286,725,474 - 86,738,865 (+)Ensembl
GRCm38.p6 Ensembl1286,678,700 - 86,692,091 (+)Ensembl
RefSeq Acc Id: NM_177354   ⟹   NP_796328
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391286,725,474 - 86,742,455 (+)NCBI
GRCm381286,678,700 - 86,695,681 (+)NCBI
MGSCv371288,019,650 - 88,036,631 (+)RGD
Celera1288,121,996 - 88,155,710 (-)NCBI
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011244107   ⟹   XP_011242409
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391286,727,129 - 86,742,462 (+)NCBI
GRCm381286,680,345 - 86,695,688 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_796328 (Get FASTA)   NCBI Sequence Viewer  
  XP_011242409 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86688 (Get FASTA)   NCBI Sequence Viewer  
  BAC41121 (Get FASTA)   NCBI Sequence Viewer  
  BAF37289 (Get FASTA)   NCBI Sequence Viewer  
  EDL02903 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000021681
  ENSMUSP00000021681.4
GenBank Protein Q8C1W1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_796328   ⟸   NM_177354
- UniProtKB: E9QKT9 (UniProtKB/Swiss-Prot),   Q8C394 (UniProtKB/Swiss-Prot),   Q8C1W1 (UniProtKB/Swiss-Prot),   A0PCF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242409   ⟸   XM_011244107
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000021681   ⟸   ENSMUST00000021681

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C1W1-F1-model_v2 AlphaFold Q8C1W1 1-375 view protein structure

Promoters
RGD ID:8678864
Promoter ID:EPDNEW_M17462
Type:initiation region
Name:Vash1_1
Description:Mus musculus vasohibin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381286,678,748 - 86,678,808EPDNEW
RGD ID:6823504
Promoter ID:MM_KWN:12232
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   Spleen
Transcripts:NM_177354,   OTTMUST00000074391
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361288,019,384 - 88,019,884 (+)MPROMDB
RGD ID:6823505
Promoter ID:MM_KWN:12233
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:UC007OHY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361288,035,081 - 88,036,097 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442543 AgrOrtholog
Ensembl Genes ENSMUSG00000021256 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021681 ENTREZGENE
  ENSMUST00000021681.4 UniProtKB/Swiss-Prot
InterPro VASH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:238328 UniProtKB/Swiss-Prot
MGD MGI:2442543 ENTREZGENE
NCBI Gene 238328 ENTREZGENE
PANTHER PTHR15750 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15750:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Vasohibin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vash1 PhenoGen
UniProt A0PCF8 ENTREZGENE, UniProtKB/TrEMBL
  E9QKT9 ENTREZGENE
  Q0VGS1_MOUSE UniProtKB/TrEMBL
  Q8C1W1 ENTREZGENE
  Q8C394 ENTREZGENE
  VASH1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QKT9 UniProtKB/Swiss-Prot
  Q8C394 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Vash1  vasohibin 1  D930046M13Rik  RIKEN cDNA D930046M13 gene  Data merged from RGD:1609517 737654 PROVISIONAL