Ear1 (eosinophil-associated, ribonuclease A family, member 1) - Rat Genome Database

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Gene: Ear1 (eosinophil-associated, ribonuclease A family, member 1) Mus musculus
Analyze
Symbol: Ear1
Name: eosinophil-associated, ribonuclease A family, member 1
RGD ID: 1620123
MGI Page MGI
Description: Predicted to enable RNA nuclease activity and lipopolysaccharide binding activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Located in cytoplasm. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EAR-1; ECP 1; eosinophil cationic protein 1; eosinophil secondary granule ribonuclease 1; eosinophil-associated ribonuclease 1; MGC151437; Raf1; ribonuclease 3-1; ribonuclease A f1; RNase 3-1
RGD Orthologs
Human
Rat
Pig
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ear-ps1   Ear-ps10   Ear-ps12   Ear-ps2   Ear-ps3   Ear-ps4   Ear-ps5   Ear-ps7   Ear-ps8   Ear-ps9  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391444,056,222 - 44,057,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1444,056,222 - 44,112,974 (-)EnsemblGRCm39 Ensembl
GRCm381443,818,765 - 43,819,639 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1443,818,765 - 43,875,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv371444,396,430 - 44,397,304 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361442,698,632 - 42,699,506 (-)NCBIMGSCv36mm8
Cytogenetic Map14C1NCBI
cM Map1422.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
extracellular space  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8901588   PMID:10594173   PMID:12466851   PMID:12477932   PMID:15058383   PMID:15526002   PMID:15676279   PMID:21873635   PMID:22677423   PMID:24337645   PMID:26075897   PMID:26147683  


Genomics

Comparative Map Data
Ear1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391444,056,222 - 44,057,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1444,056,222 - 44,112,974 (-)EnsemblGRCm39 Ensembl
GRCm381443,818,765 - 43,819,639 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1443,818,765 - 43,875,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv371444,396,430 - 44,397,304 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361442,698,632 - 42,699,506 (-)NCBIMGSCv36mm8
Cytogenetic Map14C1NCBI
cM Map1422.51NCBI
RNASE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,891,385 - 20,892,348 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,891,385 - 20,892,348 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,359,544 - 21,360,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,429,402 - 20,430,347 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,429,401 - 20,430,347NCBI
Celera141,220,428 - 1,221,373 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,480,722 - 1,481,667 (+)NCBIHuRef
CHM1_11421,361,699 - 21,362,644 (+)NCBICHM1_1
T2T-CHM13v2.01415,088,805 - 15,089,768 (+)NCBIT2T-CHM13v2.0
Rnase3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,985,399 - 26,986,269 (-)NCBIGRCr8
mRatBN7.21524,511,894 - 24,512,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,511,891 - 24,512,790 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,283,046 - 27,283,916 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,238,210 - 28,239,080 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,491,605 - 26,492,475 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,216,744 - 28,217,614 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,216,744 - 28,217,614 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,053,025 - 32,053,895 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map15p14NCBI
LOC102163838
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1778,179,285 - 78,180,221 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Ear1
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:126
Interacting mature miRNAs:128
Transcripts:ENSMUST00000100691, ENSMUST00000179200
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
D14Mit139  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
cM Map1413.5UniSTS
Whitehead Genetic1420.8UniSTS
D14Mit139.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
cM Map1413.5UniSTS
Whitehead_YAC14 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000100691   ⟹   ENSMUSP00000098256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1444,056,222 - 44,057,096 (-)Ensembl
GRCm38.p6 Ensembl1443,818,765 - 43,819,639 (-)Ensembl
Ensembl Acc Id: ENSMUST00000179200   ⟹   ENSMUSP00000136385
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1444,056,370 - 44,112,974 (-)Ensembl
GRCm38.p6 Ensembl1443,818,913 - 43,875,517 (-)Ensembl
RefSeq Acc Id: NM_007894   ⟹   NP_031920
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391444,056,222 - 44,057,096 (-)NCBI
GRCm381443,818,765 - 43,819,639 (-)ENTREZGENE
MGSCv371444,396,430 - 44,397,304 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031920   ⟸   NM_007894
- Peptide Label: precursor
- UniProtKB: P97426 (UniProtKB/Swiss-Prot),   Q53ZF0 (UniProtKB/TrEMBL),   Q9R125 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000136385   ⟸   ENSMUST00000179200
Ensembl Acc Id: ENSMUSP00000098256   ⟸   ENSMUST00000100691
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97426-F1-model_v2 AlphaFold P97426 1-155 view protein structure

Promoters
RGD ID:8682006
Promoter ID:EPDNEW_M19034
Type:single initiation site
Name:Ear1_1
Description:Mus musculus eosinophil-associated, ribonuclease A family, member1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381443,819,634 - 43,819,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108021 AgrOrtholog
Ensembl Genes ENSMUSG00000072601 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000100691 ENTREZGENE
  ENSMUST00000100691.4 UniProtKB/Swiss-Prot
  ENSMUST00000179200.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13586 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108021 ENTREZGENE
NCBI Gene 13586 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ear1 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  RNASE_PANCREATIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RNAse_Pc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ECP1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q53ZF0 ENTREZGENE, UniProtKB/TrEMBL
  Q9R125 ENTREZGENE, UniProtKB/TrEMBL